Immunodiagnosis of Human Melanoma: Detection of Circulating Melanoma-Associated Antigens by Radioimmunoassay

  • Yoshifumi Ishii
  • Giora M. Mavligit


Immunodiagnosis of cancer may provide a powerful ancillary tool for more accurate staging and judicious clinical management of patients with neoplastic disease. This is particularly true in disease categories where a high incidence of complete clinical remission can be achieved by the current therapeutic modalities. Under these circumstances, with subclinical disease in all likelihood still present, an accurate secondary tumor staging is crucial for evaluation, planning, and monitoring of further treatment. The use of a sensitive immunodiagnostic procedure under these circumstances may detect evidence for the presence of minute amounts of actively growing residual tumor, as reflected by spontaneous release of tumor antigens into the circulation (Alexander, 1974).


Melanoma Cell Melanoma Patient Human Melanoma Bacillus Calmette Guerin Culture Melanoma Cell 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Yoshifumi Ishii
    • 1
  • Giora M. Mavligit
    • 1
  1. 1.Department of Developmental TherapeuticsM. D. Anderson Hospital and Tumor InstituteHoustonUSA

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