Immunodiagnosis of Human Melanoma: Detection of Circulating Melanoma-Associated Antigens by Radioimmunoassay
Immunodiagnosis of cancer may provide a powerful ancillary tool for more accurate staging and judicious clinical management of patients with neoplastic disease. This is particularly true in disease categories where a high incidence of complete clinical remission can be achieved by the current therapeutic modalities. Under these circumstances, with subclinical disease in all likelihood still present, an accurate secondary tumor staging is crucial for evaluation, planning, and monitoring of further treatment. The use of a sensitive immunodiagnostic procedure under these circumstances may detect evidence for the presence of minute amounts of actively growing residual tumor, as reflected by spontaneous release of tumor antigens into the circulation (Alexander, 1974).
KeywordsMelanoma Cell Melanoma Patient Human Melanoma Bacillus Calmette Guerin Culture Melanoma Cell
Unable to display preview. Download preview PDF.
- Ferrone, S., and Pellegrino, M. A., 1978, Antigens and antibodies in malignant melanoma, in: The Handbook of Cancer Immunology ( H. Waters, ed.), pp. 291–327, Garland STPM Press, New York.Google Scholar
- Fritze, D., Kern, D. H., Drogemuller, C. R., and Pilch, Y. H., 1976, Production of antisera with specificity for malignant melanoma and human fetal skin, Cencer Res. 36: 458.Google Scholar
- Grosser, N., and Thomson, D. M. P., 1976, Tube leukocyte (monocyte) adherence inhibition assay for the detection of anti-tumor immunity. Ill. “Blockade” of monocyte reactivity by excess free antigen and immune complexes in advanced cancer patients, Int. J. Cancer 18: 58.Google Scholar
- Mavligit, G. M., Ambus, U., Gutterman, J. U., and Hersh, E. M., 1973, Antigen solubilized from human solid tumours: Lymphocyte stimulation and cutaneous delayed hypersensitivity, Nature (London) New Biol. 243: 188.Google Scholar
- Shuster, J., Thompson, D. M. P., and Gold, P., 1978, Immunodiagnosis, in: Immunological Aspects of Cancer ( J. E. Castro, ed.), pp. 283–312, MTP Press, Lancaster.Google Scholar