The Nature and Significance of Melanoma Antigens Recognized by Human Subjects

  • Peter Hersey
  • William H. McCarthy


Since the reports of Lewis et al. (1969) and Morton et al. (1968), a number of studies have confirmed the presence of antibodies against melanoma cells in the sera of patients with melanoma. These studies have raised considerable controversy that centered initially on the cross-reactivity of antigens detected by human antisera between different melanoma cells and then on both the biological and biochemical nature of these antigens. With the application of more stringent criteria of tumor specificity and different assay techniques, there has been renewed debate on the specificity of many of these antigens for melanoma and whether they are the focus of tumor-related immune responses by patients with melanoma.


Melanoma Cell Melanoma Patient Melanoma Cell Line Natural Killer Activity Melanoma Antigen 
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  1. Baldwin, R. W., and Embleton, M. J., 1974, Neoantigens on spontaneous and carcinogen induced rat tumours defined in vitro lymphocytotoxicity assays, Int. J. Cancer 13: 433.PubMedCrossRefGoogle Scholar
  2. Baldwin, R. W., Glaves, D., and Vose, B. M., 1974, Immunogenecity of embryonic antigens associated with chemically induced rat tumours, Int. J. Cancer 13: 135.PubMedCrossRefGoogle Scholar
  3. Bergholtz, B. O., and Thorsby, E., 1978, HLA-D restriction of the macrophage-dependent response of immune human T lymphocytes to PPD in vitro: Inhibition by anti HLA-DR antisera, Scand. J. Irnmunol. 8: 63.CrossRefGoogle Scholar
  4. Birkmayer, G. D., Hammer, C., Eberhard, H. D., and Brendel, W., 1975, A tumour specific antigen associated with reverse transcriptase in human melanoma, Behring Inst. Mitt. 56: 107.Google Scholar
  5. Bodurtha, A. J., Chee, D. O., Lauciuse, J. F., Mastrageco, M. J., and Prehn, R. T., 1975, Clinical and immunological significance of human melanoma cytotoxic antibody, Cancer Res. 35: 189.PubMedGoogle Scholar
  6. Breslow, A., 1975, Tumor thickness, level of invasion and node dissection in stage I cutaneous melanoma, Ann. Surg. 182: 572.PubMedCrossRefGoogle Scholar
  7. Carrel, S., Accolla, R. S., Carmagnola, A. L., and Mach, J. P., 1980, Common human melanoma-associated antigen(s) detected by monoclonal antibodies, Cancer Res. 40: 2523.PubMedGoogle Scholar
  8. Chechik, B. E., Schrader, W. P. and Daddona, P. E., 1980, Identification of human thymus-leukaemia-asso- ciated antigen as a low-molecular weight form of adenosine deaminase, J. Natl. Cancer Inst. 64: 1061.Google Scholar
  9. Coakham, H. B., Kornblith, P. C., Quindlen, E. A., Pollack, L. A., Wood, W. C., and Hartnett, C. C., 1980, Autologous humoral response to human gliomas and analysis of certain cell surface antigens: In vitro study with use of microcytotoxicity and immune adherence assays, J. Natl. Cancer Inst. 64: 223.PubMedGoogle Scholar
  10. Coggin, J. H., Jr., and Anderson, N. G., 1974, Cancer differentiation and embryonic antigens: Some central problems, Adv. Cancer Res. 19: 106.Google Scholar
  11. Curry, R. A., Quaranta, V., Pellegrino, M. A., and Ferrone, S., 1979, Serologically detectable human mela- noma-associated antigens are not genetically linked to HLA-A and B antigens, J. Immunol. 122: 2630.PubMedGoogle Scholar
  12. Davey, G. C., Currie, G. A., and Alexander, P., 1976, Spontaneous shedding and antibody induced modulation of histocompatibility antigens on murine lymphomata: Correlation with metastatic capacity, Br. J. Cancer 33: 9.PubMedCrossRefGoogle Scholar
  13. Dent, P. B., Carrel, S., and Mach, J. P., 1980, Detection of new cross-reacting carcinoembryonic antigen(s) on cultured tumor cells by mixed hemadsorption assay, J. Natl. Cancer Inst. 64: 309.PubMedGoogle Scholar
  14. Du Bois, D. B., and Rossen, R. D., 1980, A melanoma specific antigen identified by immunoprecipitation with human sera. Proceedings of the 4th International Conference of Immunology, Abstract 10. 1. 16.Google Scholar
  15. Edgington, T. S., and Leung, J., 1980, A candidate human breast tumor-specific membrane glycoprotein antigen, Proceedings of the 4th International Congress of Immunology, Abstract 10. 1. 17.Google Scholar
  16. Elwood, J. M., and Coldman, A. J., 1978, Previous pregnancy and melanoma prognosis, Lancet 2: 1000.Google Scholar
  17. Fidler, I. J., 1973, Selection of successive tumor lines for metastasis, Nature (London) New Biol. 242: 148.Google Scholar
  18. Garrido, F., Festenstein, H., and Schirrmacher, V., 1976, Further evidence for derepression of H-2 and Ia-like specificities of foreign haplotypes in mouse tumour lines, Nature (London) 261: 705.CrossRefGoogle Scholar
  19. Herlyn, M., Clark, W. H., Mastrangelo, M. J., Dupont, G., Elder, D. E., Larossa, D., Hamilton, R., Bondi, E., Tuthill, R., Steplewski, Z., and Koprowski, H., 1980, Specific immunoreactivity of monoclonal anti-melanoma antibodies, Cancer Res. 40: 3602.PubMedGoogle Scholar
  20. Hersey, P., 1977, Recent views on tumour antigens and their relation to host defence mechanisms, Aust. N. Z. J. Med. 7: 526.PubMedCrossRefGoogle Scholar
  21. Hersey, P., 1979, Natural killer cells: A new cytotoxic mechanism against tumours? Aust. N. Z. J. Med. 9: 464.PubMedCrossRefGoogle Scholar
  22. Hersey, P., and Isbister, J., 1979, Developments in immune complex therapy and its application to cancer, in: Human Cancer Immunology ( B. Serrou and C. Rosenfeld, eds.), pp. 135–166, Elsevier/North-Holland, Amsterdam.Google Scholar
  23. Hersey, P., Honeyman, M., Edwards, A., Adams, E., and McCarthy, W. H., 1976a, Antigens on melanoma cells detected by leucocyte-dependent antibody assays of human melanoma antisera, Int. J. Cancer 18: 564.PubMedCrossRefGoogle Scholar
  24. Hersey, P., Isbister, J., Edwards, A., Murray, E., Adams, E., Biggs, J., and Milton, G. W., 1976b, Antibody dependent cell mediated cytotoxicity against melanoma cells induced by plasmapheresis, Lancet 1: 825.PubMedCrossRefGoogle Scholar
  25. Hersey, P., Morgan, G., Stone, D., McCarthy, W. H., and Milton, G. W., 1977, Prior pregnancy as a protective factor against death from melanoma, Lancet 1: 451.PubMedCrossRefGoogle Scholar
  26. Hersey, P., Edwards, A., Milton, G. W., and McCarthy, W. H., 1978a, Relationship of cell-mediated cytotoxicity against melanoma cells to prognosis in melanoma patients, Br. J. Cancer 37: 505.CrossRefGoogle Scholar
  27. Hersey, P., Edwards, A., Murray, E., McCarthy, W. H., and Milton, G. W., 1978b, Sequential studies of melanoma leukocyte dependent antibody activity in melanoma patients, Eur. J. Cancer 14: 629.PubMedGoogle Scholar
  28. Hersey, P., Murray, E., Ruygrok, S., Edwards, A., and Milton, G. W., 1978c, Blocking factors against melanoma leukocyte-dependent antibody: Relationship to disease activity in melanoma patients, Aust. N. Z. J. Surg. 48: 26.PubMedCrossRefGoogle Scholar
  29. Hersey, P., Murray, E., and Edwards, A., 1979a, Leukocyte dependent antibody assays in melanoma patients, in: Immunodiagnosis of Human Cancer ( R. B. Herberman, ed.), pp. 599–604, Elsevier/North-Holland, New York.Google Scholar
  30. Hersey, P., Murray, E., Werkmeister, J., and McCarthy, W. H., 1979b, Detection of a low molecular weight antigen on melanoma cells by a human antiserum in leukocyte dependent antibody assays, Br. J. Cancer 40: 615.PubMedCrossRefGoogle Scholar
  31. Hersey, P., Edwards, A., and McCarthy, W. H., 1980a, Tumour related changes in natural killer cell activity in melanoma patients: Influence of stage of disease, tumour thickness and age of patient, Int. J. Cancer 25: 187.PubMedCrossRefGoogle Scholar
  32. Hersey, P., Murray, E., and McCarthy, W. H., 1980b, Evaluation of antibody inhibition assays of melanoma antigens in sera to monitor tumor growth in melanoma patients, Cancer Immunol. Immunother.Google Scholar
  33. Hollinshead, A. C., 1975, Analysis of soluble melanoma cell membrane antigens in metastatic cells of various organs and further studies of antigens present in primary melanoma, Cancer 36: 1282.PubMedCrossRefGoogle Scholar
  34. Invernizzi, G., Carbone, G., Mesachini, A., and Parmiani, G., 1977, Multiple foreign non-H-2 determinants on the surface of a chemically induced murine sarcoma, J. Immunogenet. 4: 97.PubMedCrossRefGoogle Scholar
  35. Irie, R. F., Irie, K., and Morton, D. C., 1976, A membrane antigen common to human cancer and fetal brain tissues, Cancer Res. 36: 3510.PubMedGoogle Scholar
  36. Irie, R. F., Giuliano, A., Golub, S., and Morton, D. C., 1979a, Humoral antibodies to oncofetal antigen, in: Immunodiagnosis of Human Cancer ( Irie, R. F., Giuliano, A., Golub, S., and Morton, D. C., ed.), pp. 587–596, Elsevier/North-Holland.Google Scholar
  37. Irie, R. F., Giuliano, A. E., Golub, S. H., and Morton, D. L., 19796, Oncofoetal antigen: A tumour associated fetal antigen immunogenic in man, J. Natl. Cancer Inst. 63: 367.Google Scholar
  38. Jehn, U. W., Nathanson, L., Schwartz, R. S., and Skinner, M., 1970, In vitro lymphocyte stimulation by a soluble antigen from malignant melanoma, N. Engl. J. Med. 283: 329.PubMedCrossRefGoogle Scholar
  39. Jones, P. C., Sze, L. L., Liu, P. Y., Morton, D. L., and Irie, R. F. 1981, Prolonged survival for melanoma patients with elevated IgM antibody to oncofetal antigens, J. Natl. Cancer Inst. 66: 249.PubMedGoogle Scholar
  40. Keissling, R., and Haller, O., 1978, Natural killer cells in the mouse: an alternative immune surveillance mechanism?, in: Contemporary Topics in Immunobiology, Vol. 8 ( N. L. Warner, ed.), pp. 171–179, Plenum Press, New York.CrossRefGoogle Scholar
  41. Leong, S. P., Cooperband, S. R., Sutherland, C. M., Krementz, E. T., and Deckers, P. J., 1978, Detection of melanoma antigens in cell free supernatants, J. Surg. Res. 24: 245.PubMedCrossRefGoogle Scholar
  42. Leung, J. P., and Edginton, T. S., 1980, Radioimmunoassay for tissue distribution of a human mammary tumor-specific glycoprotein, Cancer Res. 40: 662.PubMedGoogle Scholar
  43. Levy, W. L., 1978, Specificity of lymphocyte-mediated cytotoxicity in patients with primary intracranial tumours, J. Immunol. 121: 903.PubMedGoogle Scholar
  44. Lewis, M. G., 1972, Immunology of human malignant melanoma, Ser. Haematol. 5: 44.PubMedGoogle Scholar
  45. Lewis, M. G., and Phillips, T. M., 1972, The specificity of surface membrane immunofluorescence in human malignant melanoma, Int. J. Cancer 10: 105.PubMedCrossRefGoogle Scholar
  46. Lewis, M. G., Ikonopisov, R. L., Nairn, R. C., Phillips, T. M., Hamilton Fairley, G., Bodenham, D. C., and Alexander, P., 1969, Tumour specific antibodies in human malignant melanoma and their relationship to the extent of the disease, Br. Med. J. 3: 547.PubMedCrossRefGoogle Scholar
  47. Lewis, M. G., Phillips, T. M., Cook, K. B., and Blake, J., 1971, Possible explanation of loss of detectable antibody in patients with disseminated malignant melanoma, Nature (London) 232: 52.CrossRefGoogle Scholar
  48. Lewis, M. G., Hartman, D., and Jerry, L. M., 1976, Antibodies and antibodies in human malignancy: An expression of deranged immune regulation, Ann. N. Y. Acad. Sci. 276: 316.PubMedCrossRefGoogle Scholar
  49. Liao, S. K., Leong, S. P. L., Sutherland, C. M., Dent, P. B., Kwong, P. C., and Krementz, E. T., 1978, Common human melanoma membrane antigens detected by mixed hemadsorption microassay with serum from a patient undergoing immunotherapy with autologous tumour cells, Cancer Res. 38: 4395.PubMedGoogle Scholar
  50. Lloyd, K. O., Travassos, L. R., Takahashi, T., and Old, L. J., 1979, Cell surface glycoproteins of human tumor cell lines: Unusual characteristics of malignant melanoma, J. Natl. Cancer Inst. 63: 623.PubMedGoogle Scholar
  51. Macher, E., Muller, C. H. R., Sorg, G., Gassen, A., and Sorg, C., 1975, Evidence for cross-reacting membrane associated specific melanoma antigens as detected by immunofluorescence and immune adherence, Behring Inst. Mitteil. 56: 86–90.Google Scholar
  52. Malley, A., Burger, D. R., Vandenbark, A. A., Frikke, M., Finke, P., Begley, D., Acott, K., Black, J., and Vetto, M. R., 1979, Association of melanoma tumor antigen activity with 132 microglobulin, Cancer Res. 39: 619.PubMedGoogle Scholar
  53. McCabe, R. P., Ferrone, S., Pellegrino, M. A., Kern, D. H., Holmes, E. C., and Reisfelo, R. A., 1978, Purification and immunologic evaluation of human melanoma associated antigens, J. Natl. Cancer Inst. 60: 773.PubMedGoogle Scholar
  54. Mitchell, K. F., Fuhrer, J. P., Steplewski, Z., and Koprowski, H., 1981, Structural characterization of the “melanoma-specific” antigen detected by monoclonal antibody 69115 Nu-4-B, Mol. Immunol. 18: 207.PubMedCrossRefGoogle Scholar
  55. Morgan, G., McCarthy, W. H., and Hersey, P., 1977, Detection of carcinoembryonic-like antigen on melanoma cells by leukocyte-dependent antibody assays, Br. J. Cancer 36: 446.PubMedCrossRefGoogle Scholar
  56. Morgan, A. C., Rossen, R. D., and Twomey, J. J., 1979, Naturally occuring circulating immune complexes: Normal human serum contains idiotype-antiidiotype complexes dissociable by certain IgG antiglobulins, J. Immunol. 122: 1672.PubMedGoogle Scholar
  57. Morton, D. L., Malmgren, R. A., Holmes, E. C. and Ketcham, A. S., 1968, Demonstration of antibodies against human malignant melanoma by immunofluorescence, Surgery 65: 233.Google Scholar
  58. Morton, D. L., Holmes, E. C., Eilber, F. R., and Wood, W. C., 1971a, Immunological aspects of neoplasia: A rational basis for immunotherapy, Ann. Intern. Med. 74: 587.Google Scholar
  59. Morton, D. L., Eilber, R. F., and Malmgren, R. A., 1971b, Immune factors in human cancer: Malignant melanoma skeletal and soft tissue sarcomas, Prog. Exp. Tumor Res. 14: 25.PubMedGoogle Scholar
  60. Munro, A., and Bright, S., 1976, Products of the major histocompatibility complex and their relationship to the immune response, Nature (London) 264: 145.CrossRefGoogle Scholar
  61. Murray, E., McCarthy, W. H., and Hersey, P., 1977, Blocking factors against leucocyte-dependent melanoma antibody in the sera of melanoma patients, Br. J. Cancer 36: 7.PubMedCrossRefGoogle Scholar
  62. Murray, E., Ruygrok, S., McCarthy, W. H., Milton, G. W., and Hersey, P., 1978, Analysis of serum blocking factors against leukocyte dependent antibody in melanoma patients, Int. J. Cancer 21: 578.PubMedCrossRefGoogle Scholar
  63. Old, L. J., and Boyse, E. A., 1964, Immunology of experimental tumours, Annu. Rev. Med. 16: 167.CrossRefGoogle Scholar
  64. Old, L. J., Boyse, E. A., Clark, D. A., and Carswell, E. A., 1962, Antigenic properties of chemically induced tumours, Ann. N. Y. Acad. Sci. 101: 80.CrossRefGoogle Scholar
  65. Parsons, P. G., Goss, P., and Pope, J. H., 1974, Detection in human melanoma cell lines of particles with some properties in common with RNA tumour viruses, Int. J. Cancer 13: 606.PubMedCrossRefGoogle Scholar
  66. Pfreundschuh, M., Shiku, H., Takahashi, T., Ueda, R., Ransohoff, J., Oettgen, H. F., and Old, L. J., 1978, Serological analysis of cell surface antigens of malignant brain tumors, Proc. Natl. Acad. Sci. U.S.A. 75: 5122.PubMedCrossRefGoogle Scholar
  67. Preddie, E., Hartmann, D., and Lewis, M. G., 1978a, Human tumor specific antigens. 1. An allogeneic antigen from patient “PY” melanoma tumor cell plasma membranes, Cancer Biochem. Biophys. 2: 161.Google Scholar
  68. Preddie, E., Hartmann, D., Persad, S., Khosraui, M., and Lewis, M., 19786, Isolation of an autologous tumorspecific antigen from tumor cell plasma membranes of a human melanoma patient, Cancer Biochem. Biophys. 2: 199.Google Scholar
  69. Pullen, S., and Hersey, P., 1981, Reactivity of antisera to antigens of C type viruses with leukocytes from patients with acute leukaemia, Pathology 13: 289.PubMedCrossRefGoogle Scholar
  70. Ritter, M. A., and Morris, R. J., 1980, Thy-1 antigen: Selective association in lymphoid organs with the vascular basement membrane involved in lymphocyte recirculation, Immunology 39: 85.PubMedGoogle Scholar
  71. Roder, J. C., Ahrlund-Richter, L., and Jondal, M., 1979, Target-effector interaction in the human and murine natural killer system: Specificity and xenogeneic reactivity of the solubilized natural killer-target structure complex and its loss in a somatic cell hybrid, J. Exp. Med. 150: 471.PubMedCrossRefGoogle Scholar
  72. Roth, J. A., Slocum, H. K., Pellegrino, M. A., Holmes, E. C., and Reisfeld, R. A., 1976, Purification of soluble human melanoma-associated antigens, Cancer Res. 36: 2360.PubMedGoogle Scholar
  73. Salinas, F. A., Shiekh, K. M., and Chandor, S. B., 1978, Serological reactivity in cancer patients to human and mouse fetal liver cells, Cancer Res. 38: 401.PubMedGoogle Scholar
  74. Schirrmacher, V., and Bosslet, K., 1980a, Tumor metastases and cell-mediated immunity in a model system in DBA/2 mice. X. Immunoselection of tumor variants differing in tumor antigen expression and metastatic capacity, Int. J. Cancer 25: 781.PubMedCrossRefGoogle Scholar
  75. Schirrmacher, V., and Bosslet, K., 1980b, Changes in expression of tumor-associated transplantation antigens within cloned tumor cell lines, Proceedings of the 4th International Conference of Immunology, Abstract 10. 3. 38.Google Scholar
  76. Schmidt, W., Festenstein, H., and Atfield, G., 1980, Serologic and immunochemical studies on the cell membrane alloantigens of K36 on AKR spontaneous leukaemia, Transplant. Porc. 12: 29.Google Scholar
  77. Seibert, E., Sorg, C., Happle, R., and Macher, E., 1977, Membrane associated antigens of human malignant melanoma. III. Specificity of human sera reacting with cultured melanoma cells, Int. J. Cancer 19: 172.PubMedCrossRefGoogle Scholar
  78. Shaw, H. M., Milton, G. W., Farago, G., and McCarthy, W. H., 1978, Endocrine influences on survival from malignant melanoma, Cancer 42: 669.PubMedCrossRefGoogle Scholar
  79. Shearman, P. J., and Longenecker, B. M., 1980a, Selection for virulence and organ-specific metastasis of herpesvirus-tranferred lymphoma cells, Int. J. Cancer 25: 363.PubMedCrossRefGoogle Scholar
  80. Shearman, P. J., and Longenecker, B. M., 1980b, An organ specific metastasis-associated antigen detected by monoclonal antibodies, Proceedings of the 4th International Congress of Immunology, Abstract, 10. 1. 51.Google Scholar
  81. Shiku, H., Takahashi, T., Oettgen, H. F., and Old, L. J., 1976, Cell surface antigens of human malignant melanoma. II. Serological typing with immune adherence assays and definition of two new surface antigens, J. Exp. Med. 144: 873.PubMedCrossRefGoogle Scholar
  82. Shiku, H., Takahashi, T., Resnick, L. A., Oettgen, H. F., and Old, L. J., 1977, Cell surface antigens of human malignant melanoma. III. Recognition of autoantibodies with unusual characteristics, J. Exp. Med. 145: 784.PubMedCrossRefGoogle Scholar
  83. Stephenson, J. R., Essex, M., Hino, S., Aaronson, S. A., and Hardy, W. D., Jr., 1977, Feline oncornavirusassociated cell-membrane antigen (FOCMA): Distinction between FOCMA and the major virion glycoprotein, Proc. Natl. Acad. Sci. U.S.A. 74: 1219.PubMedCrossRefGoogle Scholar
  84. The, T. H., Huighes, H. A., Schrafforot Koops, H., Lamberts, H. B., and Nieweg, H. O., 1975, Surface antigens on cultured malignant melanoma cells as detected by membrane immunofluorescence method with human sera: Lack of tumor-specific reactions on melanoma lines, Ann. N. Y. Acad. Sci. 254: 528.PubMedCrossRefGoogle Scholar
  85. Thomson, D. M. P., and Alexander, P., 1973, A cross-reacting embryonic antigen in the membrane of rat sarcoma cells which is immunogenic in the syngeneic host, Br. J. Cancer 27: 35.PubMedCrossRefGoogle Scholar
  86. Thomson, D. M. P., Ralich, J. E., Weatherhead, J. C., Friedlander, P., O’Connor, R., Grosser, N., Shuster, J., and Gold, P., 1978, Isolation of human tumour-specific antigens associated with,62 microglobulin, Br. J. Cancer 37: 753.PubMedCrossRefGoogle Scholar
  87. Werkmeister, J., Edwards, A., McCarthy, W. H., and Hersey, P., 1980, Prognostic significance of expression of antigens on melanoma cells, Cancer Immunol. Immunother. 9: 233.CrossRefGoogle Scholar
  88. Whitsed, H., McCarthy, W. H., and Hersey, P., 1979, Nephelometric detection of circulating immune complexes using monoclonal rheumatoid factor, J. Immunol. Methods 29: 311.PubMedCrossRefGoogle Scholar
  89. Wilson, B. S., Indiveri, F., Pellegrino, M. A., and Ferrone, S., 1979, DR (Ia-like) antigens on human melanoma cells: Serological detection and immunochemical characterization, J. Exp. Med. 149: 658.PubMedCrossRefGoogle Scholar
  90. Winchester, R. J., Wang, C. Y., Gibofsky, A., Kunkel, H. G., Lloyd, K. O., and Old, L. J., 1978, Expression of Ia-like antigens on cultured human malignant melanoma cell lines, Proc. Natl. Acad. Sci. U.S.A. 75: 6235.PubMedCrossRefGoogle Scholar
  91. Zaunders, J., Werkmeister, J., McCarthy, W. H., and Hersey, P., 1981, Characterization of antigens recognized by natural killer cells in cell culture supernatants, Br. J. Cancer 43: 5.PubMedCrossRefGoogle Scholar
  92. Zola, H., 1980, Monoclonal antibodies against cell membrane antigens—current state of the art and potential for use in the diagnostic laboratory, Pathology 12: 539.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Peter Hersey
    • 1
  • William H. McCarthy
    • 2
  1. 1.Medical Research Department, Kanematsu Memorial InstituteSydney HospitalSydneyAustralia
  2. 2.Melanoma Unit, Department of SurgeryUniversity of Sydney, Sydney HospitalSydneyAustralia

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