Advertisement

Antigens in Human Melanomas Detected by Using Monoclonal Antibodies as Probes

  • Karl Erik Hellström
  • Ingegerd Hellström

Abstract

Some of the first evidence that human patients can react immunologically to their own tumors was obtained during the late 1960s when both humoral and cellular immune responses to putative tumor antigens were first reported (for reviews, see Herberman, 1974; K. E. Hellström and Brown, 1979). However, the nature of the antigens that were the targets in the reactions observed, and their degree of tumor specificity (if any), have been the subjects of much controversy.

Keywords

Monoclonal Antibody Melanoma Cell Binding Assay Tumor Antigen Human Melanoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bernstein, I. D., Tam, M. R., and Nowinski, R. C., 1980, Mouse leukemia therapy with monoclonal antibodies against a thymus differentiation antigen, Science 207: 68.PubMedCrossRefGoogle Scholar
  2. Brown, J. P., Tamerius, J. D., and Hellström, I. 1979, Indirect 1251-labelled protein A binding assay for monoclonal antibodies to cell surface antigens, J. Immunol. Methods 31: 201.PubMedCrossRefGoogle Scholar
  3. Brown, J. P., Wright, P. W., Hart, C. E., Woodbury, R. G., Hellström, K. E., and Hellström, I., 1980, Protein antigens of normal and malignant human cells identified by immunoprecipitation with monoclonal antibodies, J. Biol. Chem. 255: 4980.PubMedGoogle Scholar
  4. Brown, J. P., Woodbury, R. G., Hart, C. E., Hellström, I., and Hellström, K. E., 1981a, Quantitative analysis of melanoma-associated antigen p97 in normal and neoplastic tissues, Proc. Natl. Acad. Sc.:. U.S.A. 78: 539.CrossRefGoogle Scholar
  5. Brown, J. P., Nishiyama, K., Hellström, I., and Hellström, K. E., 1981b, Structural characterization of human melanoma-associated antigen p97 using monoclonal antibodies, J. Immunol. 127: 157.Google Scholar
  6. Brown, J. P., Hellström, K. E., and Hellström, I., 1981c, Use of monoclonal antibodies for quantitative analysis of antigens in normal and neoplastic tissues, Clin. Chem. 27: 1592.Google Scholar
  7. Brown, J. P. Hewick, R. M., Hellstrüm, I., and Hellstrüm, K. E., Doolittle, R. F., and Dreyer, W. J., 1982, Human melanoma-associated antigen p97 is structurally and functionally related to transferrin, Nature (in Aapress).Google Scholar
  8. Bystryn, J.-C., and Smalley, J. R., 1977, Identification and solubilization of iodinated cell surface human melanoma associated antigens, Int. J. Cancer 20: 165.PubMedCrossRefGoogle Scholar
  9. Carrel, S., Accolla, R. S., Carmagnola, A. L., and Mach, J.-P., 1980, Common human melanoma-associated antigen(s) detected by monoclonal antibodies, Cancer Res. 40: 2523.PubMedGoogle Scholar
  10. Casellas, P., H. E. Blythman, J. P. Brown, O. Gros, P. Gros, K. E. Hellstrüm, I. Hellstrüm F. K. Jansen, P. Poncelet and H. Vidal, 1981, Protides of the Biological Fluids, (ed. H. Peeters) (in apress).Google Scholar
  11. Cornain, S., de Vries, J. E., Collard, J., Vennegoor, C., Wingerden, I. V., and Rümke, P., 1975, Antibodies and antigen expression in human melanoma detected by the immune adherence test, Int. J. Cancer 19: 981.CrossRefGoogle Scholar
  12. Croce, C. M., Linnenbach, A., Hall, W., Steplewski, Z., and Koprowski, H., 1980, Production of human hybridomas secreting antibodies to measles virus, Nature (London) 288: 488.CrossRefGoogle Scholar
  13. Dippold, W. G., Lloyd, K. O., Li, L. T. C., Ikeda, H., Oettgen, H. F., and Old, L. J., 1980, Cell surface antigens of human malignant melanoma: Definition of six antigenic systems with mouse monoclonal antibodies, Proc. Natl. Acad. Sci. U.S.A. 77: 6114.PubMedCrossRefGoogle Scholar
  14. Engvall, E., and Perlmann, P., 1971, Enzyme linked immunosorbent assay (ELISA): Quantitative assay of immunoglobulin G, Immunochemistry 8: 871.PubMedCrossRefGoogle Scholar
  15. Foulds, L., 1961, Progression and carcinogenesis, Acta Unio Int. Contra Cancrum 17: 148.PubMedGoogle Scholar
  16. Galfre, G., Howe, S. C., Milstein, C., Butcher, G. W., and Howard, J. C., 1977, Antibodies to major histocompatability antigens produced by hybrid cell lines, Nature (London) 266: 550.CrossRefGoogle Scholar
  17. Garrigues, H. J., Tilgen, W., Hellstrüm, I., Franke, W., and Hellstrüm, K. E., 1982. Detection of a human melanoma-associated antigen, p97, in histological sections of primary human melanomas, submitted for publication.Google Scholar
  18. Ghose, T., and Blair, A. H., 1978, Antibody-limited cytotoxic agents in the treatment of cancer, J. Natl. Cancer Inst. 61: 657.PubMedGoogle Scholar
  19. Gilliland, D. G., Steplewski, Z., Collier, R. J., Mitchell, K. F., Chang, T. II., and Koprowski, H., 1980, Antibody-directed cytotoxic agensts: Use of monoclonal antibody to direct the action of toxin A chains to colorectal carcinoma cells, Proc. Natl. Acad. Sci. U.S.A. 77: 4539.PubMedCrossRefGoogle Scholar
  20. Gold, P., and Freedman, S. O., 1965, Demonstration of tumor-specific antigens in human colonic carcinoma by immunological tolerance and absorption techniques, J. Exp. Med. 121: 439.PubMedCrossRefGoogle Scholar
  21. Goldenberg, D. M., Kim, E. E., DeLand, F. H., Bennett, S., and Primus, F. J., 1980, Radioimmunodetection of cancer with radioactive antibodies to carcinoembryonic antigen, Cancer Res. 40: 2984.PubMedGoogle Scholar
  22. Halliday, W. J., Maluish, A. E., Little, J. H., and Davis, N. C., 1975, Leukocyte adherence inhibition and specific immunoreactivity in malignant melanoma, Int. J. Cancer 16: 645.PubMedCrossRefGoogle Scholar
  23. Hellström, I., and Hellström, K. E., 1972, Immunity to neuroblastomas and melaomas, Annu. Rev. Med. 23: 19.CrossRefGoogle Scholar
  24. Hellström, I., and Hellström, K. E., 1973, Some recent studies on cellular immunity to human melanomas, Fed. Proc. Fed. Am. Soc. Exp. Biol. 32: 156.Google Scholar
  25. Hellström, I., Hellström, K. E., and Shepard, T. H., 1970, Cell-mediated immunity against antigens common to human colonic caricnomas and fetal gut epithelium, Int. J. Cancer 6: 346.PubMedCrossRefGoogle Scholar
  26. Hellström, I., Hellström, K. E., Sjögren, H. O., and Warner, G. A., 1971, Demonstration of cell-mediated immunity to human neoplasms of various histological types, Int. J. Cancer 7: 1.PubMedCrossRefGoogle Scholar
  27. Hellström, I., Hellström, K. E., Brown, J. P., and Woodbury, R. G., 1981a, Antigens of human tumors, particularly melanomas, as studied with the monoclonal antibody technique, in: Monoclonal Antibodies and T cell hybrid Xmas, Vol. 3 (G. J. Hämmerling, et al., eds. Elsevier/North-Holland, Amsterdam.Google Scholar
  28. Hellstrüm, I., Hellstrüm, K. E., and Yeh, M.-Y., 1981b, Lymphocyte-dependent antibodies to antigen 3.1, a cell surface antigen expressed by a subgroup of human melanomas (submitted).Google Scholar
  29. Hellström, I., Brown, J. P., and Hellström, K. E., 1981c, Monoclonal antibodies to two determinants of melanoma-antigen p97 act synergistically in complement-dependent cytotoxicity, J. Immunol. 127: 157.Google Scholar
  30. Hellstrüm, I., Rollins, N., Settle, S., Chapman, P., Chapman, W. H., and Hellstrüm, K. E., 1982, Monoclonal antibodies to two mouse bladder carcinoma antigen, Int. J. Caqncer (in Apress).Google Scholar
  31. Hellström, K. E., and Brown, J. P., 1979, Tumor antigens, in: The Antigens( M. Sela, ed.), pp. 1–82, Academic Press, New York.Google Scholar
  32. Hellström, K. E., Brown, J. P., and Hellström, I., 1980, Monoclonal antibodies to tumor antigens, in: Contemporary Topics in Immunobiology, Vol. 11, ( N. L. Warner, ed.), pp. 117–137, Plenum Press, New York.Google Scholar
  33. Herberman, R. B., 1974, Cell-mediated immunity to tumor cells, Adv. Cancer Res. 19: 207.PubMedCrossRefGoogle Scholar
  34. Herlyn, D., Herlyn, M., Steplewski, Z., and Koprowski, H., 1979, Monoclonal antibodies in cell-mediated cytotoxicity against human melanoma and colorectal carcinoma, Eur. J. Immunol. 9: 657.PubMedCrossRefGoogle Scholar
  35. Herlyn, M., Steplewski, Z., Herlyn, D., and Koprowski, H., 1979, Colorectal carcinoma-specific antigen: Detection by means of monoclonal antibodies, Proc. Natl. Acad. Sci. U.S.A. 76: 1438.PubMedCrossRefGoogle Scholar
  36. Howard, J. C., Butcher, G. W., Galfre, G., and Milstein, C., 1978, Monoclonal anti-rat MHC (H-1) alloantibodies, Curr. Top. Microbiol. Immunol. 81: 54.PubMedGoogle Scholar
  37. Imai, K., Glassey, M., C., Molinaro, G. A., and Ferrone, S., 1980, Monoclonal antibodies to human melanoma associated antigens, Fed. Proc. Fed. Am. Soc. Exp. Biol. 39: 351.Google Scholar
  38. Imai, K., Wilson, B. S., Kay, N. E., and Ferrone, S. 1981. Monoclonal antibodies to human melanoma cells: comparison of erological results of several laboratories and molecular profile of melanoma-associated antigens, in: Monoclonal Antibodies and T Cell Hybridomas, Vol. 3 (G. Hämmerling et al., eds), Elsevier/ North Holland, Amsterdam.Google Scholar
  39. Jansen, F. K., Blythman, H. E., Carriere, D., Cassellas, P., Gros, O., Gros, P., Paolucci, E., Pau, B., Poncelet, P., Richer, G., Vidal, H., and Voisin, G. A., 1981, Assembly and activity of conjugates between monoclonal antibodies and the toxic subunit of ricin (immunotoxins), in: Monoclonal Antibodies and T Cell Hybridomas, Vol. 3 (G. J. Hämmerling, et al., eds.), Elsevier/North-Holland, Amsterdam.Google Scholar
  40. Kennett, R. H., and Gilbert, F., 1979, Hybrid myelomas producing antibodies against a human neuroblastoma antigen present on fetal brain, Science 203: 1120.PubMedCrossRefGoogle Scholar
  41. Kessler, S. W., 1975, Rapid isolation of antigens from cells with a Staphylococcalprotein A-antibody adsorbent: Parameters of the interaction of antibody-antigen complexes with protein A, J. Immunol. 115: 1617.PubMedGoogle Scholar
  42. Klein, E., 1968, Immunotherapy of cutaneus and mucosal neoplasms, N. Y. State J. Med. 68: 900.PubMedGoogle Scholar
  43. Klein, G., 1973, The Epstein-Barr virus, in: The Herpes Viruses( A. Kaplan, ed.), p. 521, Academic Press, New York.Google Scholar
  44. Köhler, G., and Milstein, C., 1975, Continuous culture of fused cells secreting antibodies of predefined specificity, Nature (London) 256: 495.CrossRefGoogle Scholar
  45. Köhler, G., and Milstein, C., 1976, Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion, Eur. J. Immunol. 6: 511.PubMedCrossRefGoogle Scholar
  46. Köhler, G., Howe, S. C., and Milstein, C., 1976, Fusion between immunoglobulin-secreting and nonsecreting myeloma lines, Eur. J. Immunol. 6: 292.PubMedCrossRefGoogle Scholar
  47. Koprowski, H. Steplewski, Z., Herlyn, D., and Herlyn, M., 1978, Study of antibodies against human melanoma produced by somatic cell hybrids, Proc. Natl. Acad. Sci. U.S.A. 75: 3405.PubMedCrossRefGoogle Scholar
  48. Koprowski, H., and Steplewski, Z. 1981, Human solid tumor antigens defined by monoclonal antibodies, in: Monodonal Antibodies and T Cell Hybridomas Vol. 3 (G. J. Hämmerling et al., eds), Elsevier/North Holland, Amsterdam.Google Scholar
  49. Lewis, M. G., Ikonopisov, R. L., Nairn, R. C., Phillips, T. M., Hamilton-Fairley, G., Bodenham, D. C., and Alexander, P., 1969, Tumor-specific antibodies in human malignant melanoma and their relationship to extent of disease, Br. Med. J. 3: 547.PubMedCrossRefGoogle Scholar
  50. Loop, S. M., Nishiyama, K., Hellström, I., Woodbury, R. G., Brown, J. P., and Hellström, K. E., 1981, Two human tumor-associated antigens, pl 55 and p210, detected by monoclonal antibodies Int. J. Cancer 227: 775.CrossRefGoogle Scholar
  51. McCoy, J. L., Jerome, L. F., Dean, J. H., Perlin, E., Oldham, R. K., Char, D. H., Cohen, M. H., Felix, E. L., and Herberman, R. B., 1975, Inhibition of leukocyte migration by tumor-associated antigens in soluble extracts of human malignant melanoma, J. Natl. Cancer Inst. 55: 19.PubMedGoogle Scholar
  52. Morgan, A. C., Galloway, D. R., and Reisfeld, R. A., 1981, Hybridoma 1: 27.PubMedCrossRefGoogle Scholar
  53. Mitchell, K., Fuhrer, P., Steplewski, Z., and Koprowski, H. 1980, Biochemical characterization of human melanoma cell surfaces: dissection with monoclonal antibodies. Proc. Natl. Acad. Sci. U. S. A. 77: 7267.CrossRefGoogle Scholar
  54. Morton, D. L., Malmgren, R. A., Holmes, E. C., and Ketcham, A. S., 1968, Demonstration of antibodies against human malignant melanoma by immunofluorescence, Surgery 64: 233.PubMedGoogle Scholar
  55. Nowinski, R. C., Lostrom, M. D., Tam, M. R., Stone, M. R., and Burnette, W. N., 1979, The isolation of hybrid cell lines producing monoclonal antibodies against the pl 5(E) protein of ecotropic murine leukemia viruses, Virology 93: 111.PubMedCrossRefGoogle Scholar
  56. Old, L. J., Boyse, E. A., Geering, G., and Oettgen, H. F., 1968, Serologic approaches to the study of cancer in animals and man, Cancer Res. 28: 1288.PubMedGoogle Scholar
  57. Olsson, L., and Kaplan, H. S., 1980, Human-human hybridomas producing monoclonal antibodies to predefined antigen specificity, Proc. Natl. Acad. Sci. U.S.A. 77: 5429.PubMedCrossRefGoogle Scholar
  58. Parkhouse, R. M. E., and Guarnotta, G., 1978, Rapid binding test for detection of alloantibodies to lymphocyte surface antigens, Curr. 7op. Microbiol. Immunol. 81: 142.Google Scholar
  59. Prehn, R., and Main, D., 1957, Immunity to methylcholanthrene induced sarcomas, J. Natl. Cancer Inst. 18: 768.Google Scholar
  60. Reisfeld, R. A., Galloway, D., Imai, K., Ferrone, S., and Morgan, A. C., 1980, Molecular profiles of human melanoma associated antigens, Fed. Proc. Fed. Am. Soc. Exp. Biol. 39: 351.Google Scholar
  61. Sela, M., Hurmitz, E., and Maron, R., 1979, Use of antibodies for delivery of chemtherapeutic drugs, in: The Role of Non-specific Immunity in the Prevention and Treatment of Cancer( M. Sela, ed.), p. 481, Elsevier/ North-Holland, New York.Google Scholar
  62. Shiku, H., Takahashi, T., Oettgen, H. F., and Old, L. J., 1976, Cell surface antigens of human malignant melanoma. II. Serological typing with immune adherence assays and definition of two new surface antigens, J. Exp. Med. 144: 873.PubMedCrossRefGoogle Scholar
  63. Shiku, H. J., Takahashi, T., Resnick, L. A., Oettgen, H. F., and Old, L. J., 1977, Cell surface antigens of human malignant melanoma. III. Recognition of autoantibodies with unusual characteristics, J. Exp. Med. 145: 784.PubMedCrossRefGoogle Scholar
  64. Shulman, M., Wilde, C. D., and Köhler, G., 1978, A better cell line for making hybridoma secreting specific antibodies, Nature (London) 276: 269.CrossRefGoogle Scholar
  65. Stahli, C., Stachelin, T., Miggiano, V., Schmidt, J., and Häring, P., 1980, High frequencies of antigen-specific hybridomas: Dependence of immunization parameters and prediction by spleen cell analysis, J. Immunol. Methods 32: 297.PubMedCrossRefGoogle Scholar
  66. Taranger, L. A., Chapman, W. H., Hellström, I., and Hellström, K. E., 1972, Immunological studies on urinary bladder tumors of rats and mice, Science 176: 1337.PubMedCrossRefGoogle Scholar
  67. Titani, K., Koide, A., Hermann, J., Ericsson, L. H., Kumar, S., Wade., R. D., Walsh, K. A., Neurath, H., and Fisher, E. H., 1977, Complete amino acid sequence of rabbit muscle glycogen phosphorylase, Proc. Natl. Acad. Sci. U.S.A. 74: 4762.Google Scholar
  68. Woodbury, R. G., Brown, J. P., Yeh, M.-Y., Hellström, I., and Hellström, K. E., 1980, Identification of a cell surface protein, p97, in human melanomas and certain other neoplasms, Proc. Natl. Acad. Sci. U.S.A. 77: 2183.PubMedCrossRefGoogle Scholar
  69. Woodbury, R. G., Brown, J. P., Loop, S. M., Hellström, K. E., and Hellström, I., 1981, Analysis of normal and neoplastic human tissues for the tumor-associated protein p97, Int. J. Cancer 27: 145.PubMedCrossRefGoogle Scholar
  70. Yeh, M.-Y., Hellström, I., Brown, J. P., Warner, G. A., Hansen, J. A., and Hellström, K. E., 1979, Cell surface antigens of human melanoma identified by monoclonal antibody, Proc. Natl. Acad. Sci. U.S.A. 76: 2927.PubMedCrossRefGoogle Scholar
  71. Yeh, M.-Y., Hellström, I., and Hellström, K. E., 1981, Clonal variation in expression of a human melanoma antigen defined by a monoclonal antibody, J. Immunol. 126: 1312.PubMedGoogle Scholar
  72. Yeh, M. -Y., Hellstrüm, I., Abe, K., Hakomori, S., and Hellstrüm, K. E., 1982, A cell surface antigen which is present in the gaglioside fraction and shared by human melanomas, Int. J. Cancer (in apress).Google Scholar
  73. Young, W. W., MacDonald, E. M. S., Nowinski, R. C., and Hakomori, S.-I., 1979, Production of monoclonal antibodies specific for two distinct steric portions of the glycolipid ganglio-N-triosylceramide (asialo GM2), J. Exp. Med. 150: 1008.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Karl Erik Hellström
    • 1
    • 2
  • Ingegerd Hellström
    • 1
    • 2
  1. 1.Division of Tumor ImmunologyFred Hutchinson Cancer Research CenterSeattleUSA
  2. 2.Departments of Pathology (K. E. H.) and Microbiology/ Immunology (I. H.)University of WashingtonSeattleUSA

Personalised recommendations