Behavioural Modulation by Systemic Administration of Enkephalins and Endorphins

  • Richard D. Olson
  • Abba J. Kastin
  • Gayle A. Olson
  • David H. Coy


After the discovery of opiate receptors in the brain by Goldstein et al. (1971), Pert and Snyder (1973), Simon et al. (1973) and Terenius (1973), and the subsequent identification of endogenous opiates by Hughes et al. (1975) and Terenius and Wahlstrom (1975a, b), several groups began to examine the role of these peptides in modulating behaviour. Initially, Jacquet and Marks (1976) and Bloom et al. (1976) noticed that the central administration of brain opiates resulted in profound analgesic and muscular effects. However, subsequent attempts to replicate these findings with systemic injections (Kosterlitz and Hughes, 1977) were not successful, thus restricting interest to effects of centrally administered opiates and their analogs.


Opiate Receptor Natural Behaviour Tonic Immobility Audiogenic Seizure Behavioural Modulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Belluzzi, J. and Stein, L. (1977). Nature 266, 556PubMedCrossRefGoogle Scholar
  2. Bloom, F., Segal, D., Ling, N. and Guillemin, R. (1976). Science 194, 630PubMedCrossRefGoogle Scholar
  3. Catlin, D.H., George, R. and Li, C.H. (1978). Life Sci., 23, 2147PubMedCrossRefGoogle Scholar
  4. Chipkin, R.E., Stewart, J.M., Morris, D.H. and Crowley, T.J. (1978). Pharmacol. Biochem. Behay., 9, 129CrossRefGoogle Scholar
  5. Coy, D.H., Kastin, A.J., Schally, A.V., Morin, O., Caron, N.G., Labrie, F., Walker, J.M., Fertel, R., Berntson, G.G. and Sandman, C.A. (1976). Biochem. Biophys. Res. Commun., 73, 632PubMedCrossRefGoogle Scholar
  6. Goldstein, A., Lowney, L.I. and Pal, B.K. (1971). Proc. Nat. Acad. USA, 68, 1742CrossRefGoogle Scholar
  7. Hughes, J., Smith, T.W., Kosterlitz, H.W., Fothergill, L.A., Morgan, B.A. and Morris, H.R. (1975). Nature 258, 577PubMedCrossRefGoogle Scholar
  8. Jacquet, Y.F. and Marks, N. (1976). Science 194, 632PubMedCrossRefGoogle Scholar
  9. Kastin, A.J., Nissen, C., Schally, A.V. and Coy, D.H. (1976a). Brain Res. Bull. 1, 583.PubMedCrossRefGoogle Scholar
  10. Kastin, A.J., Scollan, E.L., King, M.G., Schally, A.V. and Coy, D.H. (1976b). Pharmacol. Biochem. Behay., 5. 691CrossRefGoogle Scholar
  11. Kastin, A.J., Scollan, E.L., Ehrensing, R.H., Schally, A.V. and Coy, D.H. (1978). Pharmacol. Biochem. Behay., 9, 515CrossRefGoogle Scholar
  12. Kastin, A.J., Olson, R.D., Schally, A.V. and Coy, D.H. (1979a). Life Set. 25, 401CrossRefGoogle Scholar
  13. Kastin, A.J., Olson, R.D., Ehrensing, R.H., Berzas, M.C., Schally, A.V. and Coy, D.H. (1979b). Pharmacol. Biochem. Behay., 11, 721CrossRefGoogle Scholar
  14. Kenney, N.J., McKay, L.D. and Woods, S.C. (1978). Soc. Neurosci. Abstr., 4, 176Google Scholar
  15. King, B.M., Castellanos, F.X., Kastin, A.J., Berzas, M.C., Mauk, M.D., Olson, G.A. and Olson, R.D. (1979a). Pharmacol Biochem. Behay., 11, 729CrossRefGoogle Scholar
  16. King, M.G., Kastin, A.J., Olson, RD. and Coy, D.H. (1979b). Pharmacol Biochem. Behay., 11, 407CrossRefGoogle Scholar
  17. Kline, N.S. and Lehmann, H.E. (1978). Psychopharmacol. Bull. 14, 12PubMedGoogle Scholar
  18. Kline, N.S., Li, C.H., Lehmann, H.E., Lajtha, A., Laski, E. and Cooper, T. (1977). Arch. Gen. Psychiatry 34, 1111PubMedCrossRefGoogle Scholar
  19. Kosterlitz, H.W. and Hughes, J. (1977). Brit. J. Psychiat., 130, 298PubMedCrossRefGoogle Scholar
  20. Krebs, E. and Roubicek, J. (1979). Pharmakopsychiat. Neuropsychopharmakol. 12, 86CrossRefGoogle Scholar
  21. LeMoal, M., Koob, G.F. and Bloom, F.E. (1979). Life Sci., 24, 1631CrossRefGoogle Scholar
  22. Lipinski, J., Meyer, R., Kornetsky, C. and Cohen, B.M. (1979). Lancet 1 (8129), 1292PubMedCrossRefGoogle Scholar
  23. Margules, D.L., Moisset, B., Lewis, M.J., Shibuya, H. and Pert, C.B. (1978). Science 202, 988PubMedCrossRefGoogle Scholar
  24. Mello, N.K. and Mendelson, J.H. (1978). Pharmacol. Biochem. Behay., 9, 579CrossRefGoogle Scholar
  25. Nedopil, N. and Ruther, E. (1979). Pharmakopsychiat. Neu ropsychopharmakol. 12, 277CrossRefGoogle Scholar
  26. Olson, G.A., Olson, R.D., Kastin, A.J., Castellanos, FX., Kneale, M.T., Coy, D.H. and Wolf, R.H. (1978a). Pharmacol. Biochem. Behay., 9, 687CrossRefGoogle Scholar
  27. Olson, R.D., Kastin, A.J., Michell, G.F., Olson, G.A., Coy,D.H. and Montalbano,D. (1978b). Pharmacol Biochem. Behay., 9, 11CrossRefGoogle Scholar
  28. Olson, R.D., Kastin, A.J., Montalbano-Smith, D., Olson, G.A., Coy, D.H. and Michell, G.F., (1978c). Pharmacol. Biochem. Behay., 9, 521CrossRefGoogle Scholar
  29. Olson, G.A., Olson, R.D., Kastin, A.J., Green, M.T., Roig-Smith, R., Hill, C.W. and Coy, D.H. (1979a). Pharmacol. Biochem. Behay., 11, 341CrossRefGoogle Scholar
  30. Olson, R.D., Kastin, A.J., LaHoste, G.J., Olson, G.A. and Coy, D.H. (1979b). Pharmacol. Biochem. Behay., 11, 705CrossRefGoogle Scholar
  31. Panksepp, J., Vilberg, T., Bean, N.J., Coy, D.H. and Kastin, A.J. (1978). Brain Res. Bull. 3, 633CrossRefGoogle Scholar
  32. Pert, C. and Snyder, S. (1973). Science, 179, 1011PubMedCrossRefGoogle Scholar
  33. Plotnikoff, N.P., Kastin, A.J., Coy, D.H., Christensen, C.W., Schally, A.V. and Spirtes, M.A. (1976). Life Sci., 19, 1283PubMedCrossRefGoogle Scholar
  34. Rapoport, S.I., Klee, WA., Pettigrew, K.D. and Ohno, K. (1980). Science 207, 84 Rigter, H. (1978). Science 200, 83Google Scholar
  35. Rigter, H., Greven, H. and Van Riezen, H. (1977). Neuropharmacology 16, 545PubMedCrossRefGoogle Scholar
  36. Roemer, D., Buescher, H.H., Hill, R.C., Pless, J., Bauer, W., Cardinaux, F., Closse, A., Hauser, D. and Huguenin, R. (1977). Nature 268, 547PubMedCrossRefGoogle Scholar
  37. Ross, M., Berger, P.A. and Goldstein, A. (1979). Science 205, 1163PubMedCrossRefGoogle Scholar
  38. Sandman, C.A., McGivern, R.F., Berka, C., Walker, J.M., Coy, D.H. and Kastin, A.J. (1979). Life Sci., 25, 1755PubMedCrossRefGoogle Scholar
  39. Simon, E.J., Hiller, J.M. and Edelman, I. (1973). Proc. Nat. Acad. USA, 70, 1947CrossRefGoogle Scholar
  40. Szekely, J.I., Ronai, A.Z., Dunai-Kovacs, Z., Miglecz, E., Berzetri, I., Bajusz, S. and Graf, L. (1977). Europ. J. Pharmacol, 43, 293CrossRefGoogle Scholar
  41. Terenius, L. (1973). Acta. Pharmac. Tox., 32, 317CrossRefGoogle Scholar
  42. Terenius, L. and Wahlstrom, A. (1975a). Life Sciences, 16, 1759CrossRefGoogle Scholar
  43. Terenius, L. and Wahlstrom, A. (1975b). Acta. Physiol. Scand., 94, 74PubMedCrossRefGoogle Scholar
  44. Tseng, L.F., Loh, H.H. and Li, C.H. (1978). Int. J. Peptide Protein Res., 12, 173CrossRefGoogle Scholar
  45. Veith, J.L., Sandman, C.A., Walker, J.M., Coy, D.H. and Kastin, A.J. (1978). Pharmacol. Biochem. Behay., 20, 539Google Scholar
  46. Verhoeven, W.M., van Praag, H.M., Botter, P.A., Sunier, A., van Ree, J.M., and de Wied, D. (1978). Lancet 1 (8072), 1046Google Scholar
  47. Verhoeven, W.M., van Praag, H.M., van Ree, J.M. and de Wied, D. (1979). Arch. Gen. Psychiat., 36, 294PubMedCrossRefGoogle Scholar
  48. Wagemaker, H. and Cade, R. (1977). Am. J. Psychiat., 134, 684PubMedGoogle Scholar
  49. Weinberger, S.B., Arnsten, A. and Segal, D.S. (1979). Life Sci., 24, 1637PubMedCrossRefGoogle Scholar
  50. de Wied, D., Bohus, B., van Ree, J.M., Kovacs, G.L. and Greven, H.M. (1978a). The Lancet 1 (8072), 1046Google Scholar
  51. de Wied, D., Bohus, B., van Ree, J.M. and Urban, I. (1978b). J. Pharmacol. Exp. Ther., 204, 507Google Scholar
  52. de Wied, D., Kovacs, G.L., Bohus, B., van Ree, J.M. and Greven, H.M. (1978c). Europ. J. Pharmacol., 49, 427CrossRefGoogle Scholar

Copyright information

© Pavel D. Hrdina and Radhey L. Singhal 1981

Authors and Affiliations

  • Richard D. Olson
  • Abba J. Kastin
  • Gayle A. Olson
  • David H. Coy

There are no affiliations available

Personalised recommendations