Opiates and Neuroendocrine Regulation

  • André Dupont
  • Nicholas Barden
  • Fernand Labrie
  • Louis Ferland
  • Lionel Cusan

Abstract

Following reports of the presence of endogenous opiate activity in the brain (Pasternak et al., 1977; Terenius and Wahlstrom, 1975), two pentapeptides having the following structures: H-tyr-gly-gly-phe-met-OH (met-enkephalin) and H-tyr-gly-gly-phe-leu-OH (leu-enkephalin) have been isolated from porcine (Bradbury et al., 1976) and calf (Simantov and Snyder, 1976) brain and shown to possess high opiate-agonist activity. The sequence of met-enkephalin is the same as the N-terminus of β-endorphin (Smith et al., 1976), the C-fragment (β-LPH61-91) of β-lipotropin first isolated from sheep pituitary gland (Smith et al., 1976). It has been possible to isolate and characterize β-endorphin from camel pituitary glands (Li and Chung, 1976), as well as from many other species including the human, and both in vitro (Bradbury et al.,1976; Cox et al., 1976; Li and Chung, 1976) and in vivo (Loh et al., 1976) methods have shown it to be an analgesic agent.

Keywords

Estrogen Dopamine Morphine Serotonin Prolactin 

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References

  1. Arendash, G.W. and Gallo, R.V. (1979). Endocrinology 104, 333PubMedCrossRefGoogle Scholar
  2. Bédard, J., Dankova, J., Boucher, R. and Langelier, P. (1978). Can. J. Physiol. Pharmacol., 56, 538PubMedCrossRefGoogle Scholar
  3. Bloom, F., Battenberg, E., Rossier, J., Ling, N. and Guillemin, R. (1978). Proc. Nat. Acad. Sci. (USA) 75, 1591CrossRefGoogle Scholar
  4. Bradbury, A.F., Smyth, P.G. and Snell, C.R. (1976). Nature 260, 793CrossRefGoogle Scholar
  5. Bruni, J.F., Van Vugt, D., Marshall, S. and Meites, J. (1977). Life Sci., 21, 461Google Scholar
  6. Cicero, T.J., Schainker, B.A. and Meyer, E.R. (1979). Endocrinology 104, 1286PubMedCrossRefGoogle Scholar
  7. Cox, B.M., Goldstein, A. and Li, C.H. (1976). Proc. Nat. Acad. Sci. (USA) 73, 1821CrossRefGoogle Scholar
  8. Crowley, W.R., O’Donohue, T.L. and Jacobowitz, D.M. (1978). Brain Res., 147, 315PubMedCrossRefGoogle Scholar
  9. Cuello, A.C. and Paxinos, G. (1978). Nature 271, 178PubMedCrossRefGoogle Scholar
  10. Cusan, L., Dupont, A., Kledzik, G.S., Labrie, F., Coy, D.H. and Schally, A.V. (1977). Nature 268, 544PubMedCrossRefGoogle Scholar
  11. Dupont, A., Cusan, L., Labrie, F., Coy, D.H. and Li, C.H. (1977a). Biochem. Biophys. Res. Commun., 75, 76PubMedCrossRefGoogle Scholar
  12. Dupont, A., Cusan, L., Garon, M., Labrie, F. and Li, C.H. (1977b). Proc. Nat. Sci. (USA) 74, 358CrossRefGoogle Scholar
  13. Euvrard, C., Raynaud, J.P., Boissier, J.R. and Labrie, F. (1980). Brain Res., 169, 215CrossRefGoogle Scholar
  14. Ferland, L., Labrie, F., Arimura, A. and Schally, A.V. (1977a). J. Mol. Cell. Endocrinol., 2, 247CrossRefGoogle Scholar
  15. Ferland, L., Fuxe, K., Eneroth, P., Gustafsson, J.A. and Skett, P. (1977b). Eur. J. Pharmacol., 43, 89PubMedCrossRefGoogle Scholar
  16. Ferland, L., Kledzik, G.S., Cusan, L. and Labrie, F. (1978). J. Mol. Cell. Endocrinol., 16, 267CrossRefGoogle Scholar
  17. Ferland, L., Kledzik, G.S., Cusan, L. and Labrie, F. (1978). J. Mol. Cell. Endocrinol., 16, 267CrossRefGoogle Scholar
  18. Fuxe, K., Lofstrom, A., Eneroth, P., Gustafsson, J.A., Skett, P., Hökfelt, F., Wiesel, F.A. and Agnati, L. (1977). Psychoneuroendocrinology 2, 203PubMedCrossRefGoogle Scholar
  19. Gallo, R.V., Rabii, J. and Moberg, G.P. (1975). Endocrinology 97, 1096PubMedCrossRefGoogle Scholar
  20. Goodman, G., Lawson, D.M. and Gala, R.R. (1976). Proc. Soc. Exp. Biol. Med., 153, 225PubMedGoogle Scholar
  21. Gros, C., Pradelles, P., Humbert, J., Dray, F., Le Gal, La Salle, G. and Ben Ari, Y. (1978). Neurosc. Lett., 10, 193CrossRefGoogle Scholar
  22. Kokka, N., Garcia, J.F. and Elliot, H.W. (1973). Brain Res., 39, 347CrossRefGoogle Scholar
  23. Larsson, L.I., Childers, S. and Snyder, S. (1979). Nature 282, 407PubMedCrossRefGoogle Scholar
  24. Li, C.H. and Chung, D. (1976). Proc. Nat. Acad. Sci. (USA) 73, 1145CrossRefGoogle Scholar
  25. Lissitzky, J.C., Morin, O., Dupont, A., Labrie, F., Seidah, H.G., Chretien, M., Lis, M. and Coy, D.H. (1978). Life Sci., 22, 1715CrossRefGoogle Scholar
  26. Loh, H.H., Tseng, L.F., Wei, E.I. and Li, C.H. (1976). Proc. Nat. Acad. Sci. (USA) 73, 2895CrossRefGoogle Scholar
  27. Michelot, R., Leviel, V., Giorgirieff-Chesselet, M.F., Cheramy, A. and Glowinski, J. (1979). Life Sci., 24, 715PubMedCrossRefGoogle Scholar
  28. Neill, J.D. (1970). Endocrinology 87, 1192PubMedCrossRefGoogle Scholar
  29. Pasternak, G.W., Goodman, R. and Snyder, S.H. (1977). Life Sci., 16, 1765CrossRefGoogle Scholar
  30. Pollard, H., Llorens-Cortes, J.C., Schwartz, J.C. (1977). Nature 268, 745PubMedCrossRefGoogle Scholar
  31. Pollard, H., Llorens-Cortes, C., Schwartz, J.C., Gros, C. and Dray, F. (1978). Brain Res., 151, 392PubMedCrossRefGoogle Scholar
  32. Raymond, V., Beaulieu, M., Labrie, F. and Boissier, J.R. (1978). Science 200, 1173PubMedCrossRefGoogle Scholar
  33. Renaud, L.P. (1976). Brain Res., 105, 59PubMedCrossRefGoogle Scholar
  34. Rossier, J., Vargo, T.M., Minick, S., Ling, N., Bloom, F.E. and Guillemin, R. (1977). Proc. Nat. Acad. Sci. (USA) 74, 5162CrossRefGoogle Scholar
  35. Simantov, R. and Snyder, S. (1976). Proc. Nat. Acad. Sci. (USA) 73, 2515CrossRefGoogle Scholar
  36. Simantov, R., Kuhar, M.J., Uhl, G.R. and Snyder, S.H. (1977). Proc. Nat. Acad. Sci. (USA) 74, 2167CrossRefGoogle Scholar
  37. Smith, T.W., Hughes, J., Kosterlitz, H.W. and Sosa, R.P. (1976). In Opiates and Endogenous Opioid Peptides ( Elsevier-North Holland, Amsterdam ) p. 57Google Scholar
  38. Terenius, L. and Wahlstrom, A. (1975). Acta Physiol. Scand., 94, 74PubMedCrossRefGoogle Scholar
  39. Tolis, G., Hickey, J. and Gupta, H. (1975). J. Clin. Endocrinol. Metab., 41, 797PubMedCrossRefGoogle Scholar
  40. Von Graffenried, G., del Pozo, E., Roubicek, J., et al. (1978). Nature 272, 729CrossRefGoogle Scholar
  41. Watson, S.J., Akil, H., Richard, C.W. and Barachas, J.D. (1978). Nature 27S, 226CrossRefGoogle Scholar

Copyright information

© Pavel D. Hrdina and Radhey L. Singhal 1981

Authors and Affiliations

  • André Dupont
  • Nicholas Barden
  • Fernand Labrie
  • Louis Ferland
  • Lionel Cusan

There are no affiliations available

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