Experimental Models of Mental Illness: Separation-Induced Depression in Primates

  • Pavel D. Hrdina
  • Margaret E. Henry


Despite the impressive amount of research on the subject during the past decade or so, our understanding of the etiology of the affective disorders and of biological mechanisms underlying these conditions remains unclear. One of the limitations in investigating the biological and social variables of affective disorders has been the lack of a suitable animal model which would mimic the symptoms present in man and offer an opportunity of making a direct study of the associated biochemical changes in the brain, which, for ethical and practical reasons, cannot be studied in man. This chapter will attempt to evaluate various animal models of depression, and present data from our own investigation utilizing the separation paradigm in nonhuman primates.


Mental Illness Depressed Patient Growth Hormone Response Depressive Illness Maternal Separation 
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© Pavel D. Hrdina and Radhey L. Singhal 1981

Authors and Affiliations

  • Pavel D. Hrdina
  • Margaret E. Henry

There are no affiliations available

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