Advertisement

Laser-Doppler Continuous Real-Time Monitor of Pulsatile and Mean Blood Flow in Tissue Microcirculation

  • R. F. Bonner
  • T. R. Clem
  • P. D. Bowen
  • R. L. Bowman
Part of the NATO Advanced Study Institutes Series book series (NSSB, volume 73)

Abstract

A noninvasive instrument capable of instantaneous (~ 30 msec resolution) and continous evaluation of local flow in tissue microcirculation has been developed based on laser Doppler velocimetry. Laser light is delivered to and detected from the region to be studied by flexible, graded-index fiber optic light guides. The Doppler-broadening of laser light scattered by moving red blood cells within the tissue is analyzed in real-time by an analogue processor which provides a continuous output of the instantaneous mean Doppler frequency in the photocurrent detected by a square-law detector. The mean Doppler frequency is predicted by theory to be linearly correlated with microcirculatory blood flow in a variety of tissues, and the Laser-Doppler signal has been correlated with measurements of average tissue blood flow by other techniques. The local spatial ensemble of moving red blood cells within lmm3 of the microcirculation allows an instantaneous assessment of flow pulsations during the cardiac cycle as well as slower changes in average flow. The instrument has been designed to facilitate simple rapid clinical measurements of local spatial and temporal variations in microcirculatory flow. Measurement of local tissue blood flow in normal volunteers and patients has demonstrated the ease of accurately measuring basal and perturbed flow (reactive hyperemia, thermal hyperemia, position changes).

Keywords

Doppler Shift Doppler Frequency Reactive Hyperemia Laser Doppler Velocimetry Local Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    C. Riva, B. Ross, and G. B. Benedek, Invest. Opthal. 11: 936 (1972).Google Scholar
  2. 2.
    T. Tanaka, C. Riva, and I. Ben-Sira, Science 186: 830 (1974).ADSCrossRefGoogle Scholar
  3. 3.
    M. Stern, Nature 254: 56 (1975).ADSCrossRefGoogle Scholar
  4. 4.
    M. D. Stern, D. L. Lappe, P. D. Bowen, J. E. Chimosky, G. A. Holloway, Jr., H. R. Keiser, and R. L. Bowman, Am. J. Physiol. 232: H441 (1977).Google Scholar
  5. 5.
    M. D. Stern, P. D. Bowen, R. Parma, R. W. Osgood, R. L. Bowman, and J. H. Stein, Am. J. Physiol. 236: F80 (1979).Google Scholar
  6. 6.
    R. F. Bonner, P. Bowen, R. L. Bowman, and R. Nossal, in “Proc, Electrooptics Laser ’78 Conf.” (Indust. and Sci. Conf. Mgm’t, Inc., Chicago, 1978), p. 539.Google Scholar
  7. 7.
    R. F. Bonner and R. Nossal, Applied Optics (June 1981).Google Scholar
  8. 8.
    R. Nossal, S. H. Chen, and C. C. Lai, Optics Comm, 4: 35 (1971).ADSCrossRefGoogle Scholar
  9. 9.
    P. C. Williams, M. D. Stern, P. D. Bowen, R. Brooks, M, K, Hammock, R. L. Bowman, and G. DiChiro, Med. Res, Eng. 13: 3 (1980).Google Scholar
  10. 10.
    D. Watkins and G. A. Holloway, Jr., IEEE Trans. Biomed. Engr. BME-25: 28 (1978).CrossRefGoogle Scholar
  11. 11.
    G. E. Nilsson, T. Tenland, and P. A. Oberg, IEEE Trans. Biomed. Engr. BME-27: 12 (1980).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • R. F. Bonner
    • 1
  • T. R. Clem
    • 1
  • P. D. Bowen
    • 2
  • R. L. Bowman
    • 2
  1. 1.Biomedical Engineering and Instrumentation Branch, DRSNational Institutes of HealthBethesdaUSA
  2. 2.Laboratory of Technical Development, NHLBINational Institutes of HealthBethesdaUSA

Personalised recommendations