Risk Factors for Deficits in Early Cognitive Development

  • Sarah H. Broman
Part of the Environmental Science Research book series (ESRH, volume 21)


The current emphasis on risk assessment, a methodology introduced in the early fifties (1), has been attributed to a decreased public tolerance for exposure to potentially harmful events, particularly if the exposure is perceived as involuntary and widespread (2). Efforts to identify risk factors are certainly not new, nor have they been unproductive. What has become increasingly urgent is the need to carry out the complex tasks involved in quantifying risks so that their relative importance can be evaluated. It is well-recognized that all segments of the population are not at equal risk following similar exposure to an injurious event. Examples of susceptible subpopulations are pregnant women, infants, and young children. In this paper, methods of identifying and evaluating risk factors for cognitive deficits in infancy and early childhood are illustrated by findings from a large-scale longitudinal study of the developmental consequences of complications in pregnancy and the perinatal period. Between 1959 and 1974, the offspring from 53,043 pregnancies were followed from gestation through eight years of age in the Collaborative Perinatal Project of the National Institute of Neurological and Communicative Disorders and Stroke. Women in the study were selected by site of prenatal care. Abnormal outcomes of particular interest were cerebral palsy, mental retardation, congenital malformations, and learning disorders. Causes of perinatal death and prematurity were also investigated, as were factors related to physical and cognitive growth. The goals of the Perinatal Project were heavily influenced by the work of Lilienfeld, and Knobloch and Pasamanick and colleagues who carried out a series of retrospective studies to investigate the concept of a continuum of reproductive casualty, an hypothesis that complications in pregnancy and the perinatal period can produce a spectrum of abnormalities ranging from fetal or neonatal death through severe to mild neurological deficit (3,4).


Cerebral Palsy Cognitive Deficit Fetal Alcohol Syndrome Discriminant Function Analysis Severe Mental Retardation 


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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Sarah H. Broman
    • 1
  1. 1.National Institute of Neurological and Communicative Disorders and StrokeBethesdaUSA

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