The Cancer Risk from Low Level Radiation

  • Bernard L. Cohen
Part of the Environmental Science Research book series (ESRH, volume 21)


There have been many situations in which large numbers of people have been exposed to high levels of radiation, and through studies of them1,2 the health effects of high level radiation are rather well known. Among the survivors of the atomic bomb attacks on Japan, there were 24,000 people who received an average exposure of 130 rem, and about 120 extra cancers developed among them up to 1972. There were 15,000 British patients treated with X-rays for ankylosing spondylitis (arthritis of the spine) with doses averaging 370 rem, and they had about 115 extra cancers. Over 900 Germans were treated for that same disease with injections of radium-224 giving an average dose to the bone of 4400 rem*, and 45 of them got bone cancer (vs 0.1 expected). About 1700 U.S. women employed during the 1920s in painting radium on clock and watch dial numerals to make them self-luminous used their tongues to put a fine tip on the brush, getting radium into their bodies; their average bone dose was 17,000 rem and 48 of them died of bone cancer (vs 0.4 expected). Among 4100 U.S. uranium miners exposed to excess levels of radon gas due to poor mine ventilation, the average exposure to bronchial surfaces was 4700 rem and up to 1972 there were 135 lung cancer deaths among them vs 16 expected. There have been several other miner groups which have experienced excess lung cancers, like a group of 800 Canadian fluorspar miners whose average bronchial exposure was 2800 rem, resulting in 51 lung cancer deaths vs 2.8 expected.


Uranium Miner Doubling Dose Radon Exposure Linear Hypothesis Health Phys 


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  1. 1.
    NAS (National Academy of Sciences) “The Effects on Populations of Exposure to Low Levels of Ionizing Radiation”, Washington, DC, (1972).Google Scholar
  2. 2.
    UNSCEAR (United Nations Scientific Com. on Effects of Atomic Radiation), “Sources and Effects of Ionizing Radiation”, United Nations, New York, (1977).Google Scholar
  3. 3.
    J.F. Fowler and J. Denekamp, Chapter 5, p.139, in: “Cancer”, S.S. Becker, ed., Plenum Publishing Co., New York (1977).Google Scholar
  4. 4.
    D. Grahn, R.J.M. Fry, and R.A. Lea, Volume X, in: “Life Sciences and Space Research,” A.C. Strickland, ed., Akademie-Verlag, Berlin (1972).Google Scholar
  5. 5.
    C.J. Shellabarger, V.P. Bond, G.E. Aponte, and E.P. Cronkite, Cancer Res. 26:509 (1966).PubMedGoogle Scholar
  6. 6.
    A.C. Upton, et al., Rad. Res. 41, 467 (1970).CrossRefGoogle Scholar
  7. 7.
    R. H. Mole, Brit. Jour. of Radiology, 32:497 (1959).CrossRefGoogle Scholar
  8. 8.
    H. Speiss and C.W. Mays, in “Radionuclide Carcinogenesis,” C.L. Sanders et al, ed., USAEC Report CONF-720505, p.437 (1973).Google Scholar
  9. 9.
    J.M. Brown, Health Phys. 31:231 (1976).PubMedCrossRefGoogle Scholar
  10. 10.
    W.L. Russell, Peaceful Uses of Atomic Energy, IAEA Publ. ST1/PUB 1300, Vol. 13, p. 487, Vienna (1972).Google Scholar
  11. 11.
    D.E. Lea, “Actions of Radiation on Living Cells,” Cambridge Univ. Press, London (1955).Google Scholar
  12. 12.
    S. Wolff, p. 157, in: “Radiation Protection and Recovery,” A. Hollaender, ed., Macmillan, New York (1961).Google Scholar
  13. 13.
    B.W. Fox and L.G. Lajtha, Brit. Med. Bul. 29:16 (1973).Google Scholar
  14. 14.
    M.M. Elkind and J.L. Redpath, Chapter 3, p. 51, in: “Cancer,” S.S. Bicker, ed., Plenum Publishing Co., New York (1977).Google Scholar
  15. 15.
    United Nations Scientific Com. on Effects of Atomic Rad., “Ionizing Radiation: Levels and Effects,” United Nations, New York (1972).Google Scholar
  16. 16.
    R.A. McGrath and R.W. Williams, Nature 212:534 (1966).PubMedCrossRefGoogle Scholar
  17. 17.
    C.D. Town, K.C. Smith, and H.S. Kaplan, Radiation Res. 52:99 (1973).CrossRefGoogle Scholar
  18. 18.
    John Marshall (Argonne National Lab), private communication (1978).Google Scholar
  19. 19.
    M.M. Elkind, G.F. Whitmore, “The Radiobiology of Cultured Mammalian Cells,” Gordon and Breach, New York (1967).Google Scholar
  20. 20.
    A.M. Kellerer & H.H. Rossi, Current Topics in Radiation Research, 8:85 (1972).Google Scholar
  21. 21.
    ICRP (International Commission on Radiological Protection), Report of Committee II on Permissible Dose for Internal Radiation, ICRP Publication 2, Pergamon Press, NY (1959).Google Scholar
  22. 22.
    E. Schmid, G. Rimpe, and M. Bauchinger, Rad. Res. 57:228 (1973).CrossRefGoogle Scholar
  23. 23.
    A.M. Kellerer and H.H. Rossi, Vol. 1, p. 405, in: “Cancer,” F.F. Becker, ed., Plenum Publ. Co., NY (1975).Google Scholar
  24. 24.
    A.C. Upton, Cancer Res. 21:717 (1961).PubMedGoogle Scholar
  25. 25.
    M.P. Finkel and B.O. Biskis, Prog. Exp. Tumor Res. 10:72 (1968).Google Scholar
  26. 26.
    F.J. Burns, R.E. Albert, R.D. Heimbach, Rad. Res. 36:225 (1968).CrossRefGoogle Scholar
  27. 27.
    P. Maldague, in: “Radiation Induced Cancer,” IAEA, Vienna, (1969).Google Scholar
  28. 28.
    C.W. Mays, T.F. Dougherty, G.N. Taylor, B.J. Stover, W.S.S. Jee, W.R. Christensen, J.H. Dougherty, W. Stephens, and C. Nabors, Hearings on Env. Effects of Producing Electric Power, Joint Com. on Atom. En., U.S. Congress, Vol. II, Part 2, p. 2192 (1970).Google Scholar
  29. 29.
    C.W. Mays and R.D. Lloyd, in “Biochemical Implications of Radiostrontium Exposure,” M. Goldman and L.K. Bustad, eds., USAEC Report CONF-710201 (1972).Google Scholar
  30. 30.
    J.B. Storer in “Cancer,” F.F. Becker, ed., Plenum Publ. Co., New York, 453 (1975).Google Scholar
  31. 31.
    C.J. Shellabarger, V.P. Bond, E.P. Cronkite, and G.E. Aponte, in: “Radiation Induced Cancer,” IAEA, Vienna, p. 61 (1969).Google Scholar
  32. 32.
    C.W. Mays, Argonne National Lab Symposium on “National Energy Issues — Plutonium as a Test Case,” R.G. Sachs, ed., Sept. (1978).Google Scholar
  33. 33.
    M.P. Finkel, B.O. Biskis, and P.B. Jenkins, in “Radiation Induced Cancer,” A. Ericson, ed., Int. At. En. Ag., Vienna, p. 369 (1969).Google Scholar
  34. 34.
    G.W. Beebe, H. Kato, and C.E. Land, Radiation Effects Research Found. Report RERF TR1-77 (1977).Google Scholar
  35. 35.
    R.E. Rowland, A.F. Stehney, and H.F. Lucas, Rad. Res. 76:368 (1978).CrossRefGoogle Scholar
  36. 36.
    A.F. Cohen and B.L. Cohen, Tests of the Linearity Assumption in the Dose-Effect Relationship for Radiation-Induced Cancer, Health Physics 38:53–69 (1980).PubMedCrossRefGoogle Scholar
  37. 37.
    V.E. Archer, G. Saccomanno, and J.H. Jones, Cancer 34:2056 (1974).PubMedCrossRefGoogle Scholar
  38. 38.
    A.C. Upton, Nat’l. Cancer Inst. Monog. 14:221 (1964).Google Scholar
  39. 39.
    E.V. Hulse, Brit. Jour. Cancer 21:531 (1967).CrossRefGoogle Scholar
  40. 40.
    T.F. Dougherty and C.W. Mays, in “Radiation Induced Cancer,” Int. At. En. Agency (1969). Paper IAEA-SM-118/3, p. 361.Google Scholar
  41. 41.
    O. Hug, W. Gossner, W.A. Muller, A. Luz, and B. Hindringer, in “Radiation Induced Cancer,” IAEA, Vienna, p. 393 (1969).Google Scholar
  42. 42.
    A. Nilsson, Acta Radiol. Ther. Phys. Biol. 9:155 (1970).PubMedGoogle Scholar
  43. 43.
    C.W. Mays, H. Speiss, and A. Gerspach, Health Physics 35:83 (1978).PubMedCrossRefGoogle Scholar
  44. 44.
    T. Kitabatake, T. Watanabe, and S. Koga, Strahlentherapie 146:599 (1973).PubMedGoogle Scholar
  45. 45.
    R.D. Evans, Health Phys. 27:497 (1974).CrossRefGoogle Scholar
  46. 46.
    T.F. Mancuso, A. Stewart, and G. Kneale, Health Phys. 33:369 (1977). Referred to as MSK.PubMedCrossRefGoogle Scholar
  47. 47.
    G. Kneale, A. Stewart, and T.F. Mancuso, IAEA Symposium on the Late Biological Effects of Ionizing Radiation, Vienna, March (1978).Google Scholar
  48. 48.
    E.S. Gilbert, Testimony for U.S. House of Representatives Subcommittee on Health and the Environment; also available as document PNL-SA-6341 Rev. (1978).Google Scholar
  49. 49.
    E.S. Gilbert, “Methods of Analyzing Mortality of Workers Exposed to Low-levels of Ionizing Radiation,” Battelle Pacific Northwest Lab Report BNW1-SA-634, May (1977).Google Scholar
  50. 50.
    S. Marks, E.S. Gilbert, and B.D. Breitenstein, “Cancer Mortality in Hanford Workers,” Int. Atomic En. Agency Document IAEA-SM-224. (1978).Google Scholar
  51. 51.
    A. Brodsky, Testimony for U.S. House of Representatives Subcommittee on Health and the Environment, Feb. 8 (1978).Google Scholar
  52. 52.
    L.A. Sagan, “Low Level Radiation Effects: The Mancuso Study,” Electric Power Research Institute Report (1978); Atom, No. 262, August (1978).Google Scholar
  53. 53.
    B.S. Sanders, Health Phys. 34:521 (1978).PubMedCrossRefGoogle Scholar
  54. 54.
    D.J. Kleitman, “Critique of Mancuso-Stewart-Kneal Report,” Submission to U.S. Nuc. Reg. Com., March 2 (1978).Google Scholar
  55. 55.
    J.A. Reissland and G.W. Dolphin, Radiation Protection Bulletin No. 23, U.K. Natl. Rad. Prot. Bd., Harwell (1978).Google Scholar
  56. 56.
    Hon. Mr. Justice Parker, “The Windscale Inquiry,” Her Majesty’s Stationery Office, London, Jan. 26 (1978).Google Scholar
  57. 57.
    T.W. Anderson, Health Phys. (in print).Google Scholar
  58. 58.
    NRC (U.S. Nuc. Reg. Com.), Staff Committee Report of Nov., (1976).Google Scholar
  59. 59.
    NRC (U.S. Nuc. Reg. Com.), Staff Committee Report of May, (1978).Google Scholar
  60. 60.
    D. Rubenstein, Report to U.S. Nuclear Regulatory Commission (1978).Google Scholar
  61. 61.
    G.B. Hutchinson, B. MacMahon, S. Jablon, and C.E. Land, Health Physics 37:207 (1979).CrossRefGoogle Scholar
  62. 62.
    G.W.C. Tait, Health Phys. 37:251 (1979).PubMedGoogle Scholar
  63. 63.
    B.L. Cohen, Health Phys. 35:582 (1978).PubMedGoogle Scholar
  64. 64.
    R. Mole, Lancet 1978–1, p. 582 (1978).Google Scholar
  65. 65.
    S.M. Gertz, Health Phys. 35:723 (1978).PubMedGoogle Scholar
  66. 66.
    B.L. Cohen, “The Low-level Radiation Link to Cancer of the Pancreas,” Health Phys. (in print).Google Scholar
  67. 67.
    H. Nishiyama, et al, Cancer 32: 1301 (1973).PubMedCrossRefGoogle Scholar
  68. 68.
    C.W. Mays, private communication.Google Scholar
  69. 69.
    B. Castleman, private communication.Google Scholar
  70. 70.
    J. Rotblat, Bul. Atomic Scientists, September (1978).Google Scholar
  71. 71.
    B.L. Cohen, Bul. Atomic Scientists, February, p. 53 (1979).Google Scholar
  72. 72.
    T. Najarian and T. Colton, Lancet 1978–1, p.1018, (1978).Google Scholar
  73. 73.
    R.E. Lapp, “The Radiation Controversy,” Reddy Communications, Greenwich, Connecticut (1979).Google Scholar
  74. 74.
    S. Milham, “Occupational Mortality in Washington State 1950–71,” Report to Dept. HEW-NIOSH, Cincinnati, April (1976).Google Scholar
  75. 75.
    S. Wermiel, “Doctors Shift on Shipyard: Kennedy Chides Portsmouth Research er, “Boston Globe, June 20 (1979).Google Scholar
  76. 76.
    I.D.J. Bross, M. Bali, and S. Falen, Am. Jour. Pub. Health 69:130 (1979).CrossRefGoogle Scholar
  77. 77.
    J.D. Boice, and C.E. Land, Am. Jour. Pub. Health 69:137 (1979).CrossRefGoogle Scholar
  78. 78.
    R. Gibson, I.D.J. Bross, et al, New Eng. J. Med. 279:906 (1968).PubMedCrossRefGoogle Scholar
  79. 79.
    I.D.J. Bross and N. Natarajan, New Eng. J. Med., 287:107 (1972).PubMedCrossRefGoogle Scholar
  80. 80.
    I.D.J. Bross and N. Natarajan, Jour. Am. Med. Assn. 237:2399 (1977).CrossRefGoogle Scholar
  81. 81.
    B. MacMahon, New Eng. Jour. Med. 287:144 (1972).CrossRefGoogle Scholar
  82. 82.
    R.H. Mole, Brit. J. Cancer 30:199 (1974).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Bernard L. Cohen
    • 1
  1. 1.Department of Physics and AstronomyUniversity of PittsburghPittsburghUSA

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