Evaluation of Genetic Risks

  • James F. Crow
  • Carter Denniston
Part of the Environmental Science Research book series (ESRH, volume 21)


Measuring the impact of an increased mutation rate on future human generations is a two-fold problem: First one must assess the damage to the genetic material itself, and second, one must determine the likely effect of such damage on the welfare of future generations.


Mutation Rate Sickle Cell Anemia Recessive Mutant Genetic Damage Spontaneous Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Ames, B. N., McCann, J., and Yamasaki, E.: Methods of detecting carcinogens and mutagens with the Salmonella-microsome mutagenicity test. Mutation Res., 31:347 (1975).PubMedGoogle Scholar
  2. 2.
    Scott, D., Bridges, B. A., and Sobels, F. H., Eds.: Progress in Genetic Toxicology. Elsevier/North Holland Biomedical Press, Amsterdam (1977).Google Scholar
  3. 3.
    Griffen, A. C., and Shaw, C. R., Eds.: Carcinogens: Identification and Mechanisms of Action. Raven Press, New York (1979).Google Scholar
  4. 4.
    Hiatt, H. H., Watson, J. D., and Winsten, J. A., Eds.: Origins of Human Cancer, Cold Spring Harbor Lab., New York (1977).Google Scholar
  5. 5.
    Hollaender, A., and deSerres, F. J., Eds: Chemical Mutagens Principles and Methods for their Detection. Plenum Press. New York (1978).Google Scholar
  6. 6.
    Brusick, D.: Unified scoring system and activity definitions for results from in vitro and submammalian mutagenesis test batteries. In Press.Google Scholar
  7. 7.
    McKusick, V: Mendelian Inheritance in Man, 5th ed. Johns Hopkins Press. (1978).Google Scholar
  8. 8.
    Crow, J. F.: Minor viability mutants in Drosophila. Genetics 92: s165 (1979).PubMedGoogle Scholar
  9. 9.
    BEIR: The Effects on Populations of Exposure to Low Levels of Ionizing Radiation. National Academy of Sciences, Washington (1972).Google Scholar
  10. 10.
    Muller, H. J: Our load of mutations. Amer. J. Human Genet. 2:11 (1950).Google Scholar
  11. 11.
    BEAR: The Biological Effects of Atomic Radiation. National Academy of Sciences, Washington (1956).Google Scholar
  12. 12.
    UNSCEAR: Sources and Effects of Ionizing Radiation. United Nations, New York (1977).Google Scholar
  13. 13.
    Committee 17 of Environmental Mutagen Society: Environmental mutagenic hazards. Science 187:503 (1975).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • James F. Crow
    • 1
  • Carter Denniston
    • 1
  1. 1.Department of Medical GeneticsUniversity of WisconsinMadisonUSA

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