Implications for Immunisation: The Milk IgA Antibody Response to Live and Inactivated Polio Virus Vaccines

  • L. Å. Hanson
  • B. Carlsson
  • F. Jalil
  • B. S. Lindblad
  • A-M. Svennerholm
Part of the Ettore Majorana International Science Series book series (volume 8)


Human milk is rich in secretory IgA (SIgA) antibodies, many of which are directed against food vroteins and antigens of microorganisms found in the intestine(1,2,3). The appearance of these milk antibodies against antigens from the intestinal content is explained by the enteromammaric link: antigenic exposure of the Peyer’s patches leads to homing of cells committed to IgA sunthesis to various exocrine glands, including the mammary gland (4,5). In addition there may be a selective transfer via serum or IgA dimer-J chain complexes that are taken up by secretory component (SC). The SC which is produced in epithelial cells in exocrine glands functions as a receptor on the cell membrane of these epithelial cells. SIgA is formed by the binding of IgA-J to the SC and is transferred into the exocrine secretion. At least in mice this serum transfer may provide a substantial portion of the milk SIgA(6 Halsey personal communication). Presumably the serum IgA dimers originate from the extensive production of IgA in the intestinal lamina propria.


Secretory Component Polio Virus Cholera Vaccine Inactivate Polio Virus Vaccine Pakistani Woman 
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  1. 1.
    Gindrat J-J., Gothefors L., Hanson L.Å. and Winberg J. (1972) Acta Paediatr. Scand. 61: 587–590.PubMedCrossRefGoogle Scholar
  2. 2.
    Holmgren J., Hanson L.Å., Carlsson B., Lindlad B.S. and Rahimtoola J. (1976) Scand. J. Immunol. 5: 867–871.PubMedCrossRefGoogle Scholar
  3. 3.
    Hanson L.R., Carlsson B., Cruz J.R., Garcia B., Holmgren J., Shaukat R. Khan, Lindlad B.S., Svennerholm A-M., Svennerholm B. and Urrutia J.J. (1979) in “Immunology of Breast Milk”, Ogra P.L. and Dayton D. eds., Raven Press, New York, p. 145.Google Scholar
  4. 4.
    Lamm M.E., Weisz-Carrington P., Roux E., McWilliams M. and Phillips-Quagliata J.M. (1979) in “Immunology of Breast Milk”, Ogra P.L. and Dayton D. eds., Raven Press, New York, p. 105.Google Scholar
  5. 5.
    Bienenstock J., McDermott M. and Befus D. (1979) in “Immunology of Breast Milk”, Ogra P.L. and Dayton D. eds., Raven Press, New York, p. 91.Google Scholar
  6. 6.
    Halsey J., Johnson B.H. and Cebra J. (1980) J. Exp. Med. 151: 767–772.PubMedCrossRefGoogle Scholar
  7. 7.
    Porter P., Noakes D.E. and Allen W.D. (1970) Immunology 18: 245–257.PubMedGoogle Scholar
  8. 8.
    Bohl E.H., Gupta R.P.K., Olquin F.M.W. and Saif L.J. (1972) Infect. Immun. 6: 289–301PubMedGoogle Scholar
  9. Bohl E.H. and Saif L.J. (1975) Infect Immun. 11: 23–32.PubMedGoogle Scholar
  10. 9.
    Montgomery P.C., Cohn J. and Lally E.T. (1974) in “The Immunoglobulin A System”, Mestecky J. and Lawton A.R. eds., Plenum Press, New York, p. 453.CrossRefGoogle Scholar
  11. 10.
    Montgomery P.C., Cohen C., Skandera C.A. and Connelly K.M. (1979) in “Immunology of Breast Milk” Ogra P.L. and Dayton D. eds., Raven Press, New York, p. 115.Google Scholar
  12. 11.
    Goldblum R.M., Ahlstedt S., Carlsson B., Hanson L.R., Jodal U., Lídin-Janson G. and Sohl-Rkerlund A. (1975) Nature 257: 797–799.PubMedCrossRefGoogle Scholar
  13. 12.
    Porter P. and Chidlow J.W. (1979) in “Immunology of Breast Milk”, Ogra P.L. and Dayton D. eds., Raven Press, New York, p. 49.Google Scholar
  14. 13.
    Saíf L.J. and Bohl E.H. (1979) in “Immunology of Breast Milk”, Ogra P.L. and Dayton D. eds., Raven Press, New York, p. 237.Google Scholar
  15. 14.
    Svennerholm A-M, Holmgren J., Hanson L.R., Lindblad B.S., Quereshi F. and Rahimtoola J. (1977) Scand. J. Immunol. 6: 1345–1349.PubMedCrossRefGoogle Scholar
  16. 15.
    Svennerholm A-M., Hanson L.R., Holmgren J., Lindblad B.S., Nilsson B. and Quereshi F. (1980) Infect. Immun. (in press).Google Scholar
  17. 16.
    Svennerholm A-M., Hanson L.R., Svennerholm B., Holmgren J., Lindblad B.S. and Shaukat R. Kahn (1981) J. Infect. Dis. (in press).Google Scholar
  18. 17.
    Pierce N.F. and Gowans J.L. (1975) J. Exp. Med. 142: 1550–1563.PubMedCrossRefGoogle Scholar
  19. 18.
    Pierce N.F. (1978) J. Exp. Med. 148: 195–206.PubMedCrossRefGoogle Scholar
  20. 19.
    Lange S. and Holmgren J. (1978) Acta Path. Microbiol. Scand., Sect. C 86: 145–152.Google Scholar
  21. 20.
    Elson C.O., Heck J.A. and Strober W. (1979) J. Exp. Med. 149: 632–641.PubMedCrossRefGoogle Scholar
  22. 21.
    Richman L.K. (1979) in “Immunology of Breast Milk”, Ogra P.L. and Dayton D. eds., Raven Press, New York, p. 49Google Scholar
  23. Sabin A.B. (1980) Bull. WHO 58: 141–157.PubMedGoogle Scholar
  24. 22.
    Warren R.J., Lepow M.L., Bartsch G.E. and Robbins F.C. (1964) Pediatrics 34: 4–13.PubMedGoogle Scholar
  25. 23.
    Smith C.B., Purcell R.H., Bellanti J.A. and Chanock R.M. (1966) New Eng. J. Med. 275: 1145–1152.PubMedCrossRefGoogle Scholar
  26. 24.
    Perkins J.C., Knopf H.L.S., Kapikian A.Z. and Chanock R.M. (1971) in “The Secretory Immunologic System”, Dayton D., Small P.A., Chanock R.M., Kaufman H.E. and Tomasi T.B. eds., U.S. Dept. of Health, Education and Welfare, NIH, Bethesda, p. 203.Google Scholar
  27. 25.
    Ogra P.L. and Carzon D.T. (1969) J. Immunol. 102: 1423–1431.PubMedGoogle Scholar
  28. 26.
    Deforest A., Parker P.B., Di Liberti J.H., Yates H.T. Jr., Sikinga M.S. and Smith D.S. (1973) Pediatrics 83: 93–95.CrossRefGoogle Scholar
  29. 27.
    Dömök I., Balayan M.S., Fayinka O.A., §krtié N., Soneji A.D. and Harland P.S.E.G. (1974) Bull. WHO 51: 333–347.PubMedGoogle Scholar
  30. 28.
    John T.J., Devarajan L.V., Luther L. and Vijagarathman P. (1976) Pediatrics 57: 47–53.PubMedGoogle Scholar
  31. 29.
    Montefiore D., Collard P., Jamieson M.F. and Jolly H. (1963) BMJ II 1569–1572.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • L. Å. Hanson
    • 1
    • 2
    • 3
  • B. Carlsson
    • 1
    • 2
    • 3
  • F. Jalil
    • 1
    • 2
    • 3
  • B. S. Lindblad
    • 1
    • 2
    • 3
  • A-M. Svennerholm
    • 1
    • 2
    • 3
  1. 1.Institute of Medical Microbiology and Department of PediatricsUniversity of GöteborgSweden
  2. 2.Department of Social and Preventive PediatricsKing Edward Medical CollegeLahorePakistan
  3. 3.Department of Pediatrics of the Karolinska InstituteSt. Göran’s HospitalStockholmSweden

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