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The Secretory Immune System

  • John Bienenstock
Part of the Ettore Majorana International Science Series book series (volume 8)

Abstract

When we consider that we interact with our environment and are separated from it by only a thin layer of cells, it is not surprising that an immune system has evolved to regulate potentially pathogenic organisms and products of that environment such as dietary antigens. It is my purpose briefly to review the secretory or mucosal immune system and attempt to show how far this system is integrated with the rest of the immunologic apparatus. The material contained in this contribution may be found in an expanded form elsewhere(1,2).

Keywords

Lamina Propria Mucosal Tissue Mucosa Associate Lymphoid Tissue Mucosal Immune System Secretory Component 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bienenstock J. and Befus A.D.M., in Strober W. ed., Humana, N.J. (in press).Google Scholar
  2. 2.
    Bienenstock J. and Befus A.D.M., Immunology (in press).Google Scholar
  3. 3.
    Heremans J.F. (1974) in “The Antigens, II”, ed. Sela M., Academic PRess, N.Y., p. 365.Google Scholar
  4. 4.
    Lemaitre-Coelho I., Jackson G.D.F. and Vaerman J-P. (1978) J. Exp. Med. 147: 934.PubMedCrossRefGoogle Scholar
  5. 5.
    Orlans E., Peppard J., Reynolds J. and Hall J. (1978) J. Exp. Med. 147: 588.PubMedCrossRefGoogle Scholar
  6. 6.
    Socken D.J. and Underdown B.J. (1978) Immunochemistry 15: 499.PubMedCrossRefGoogle Scholar
  7. 7.
    Montgomery P.C., Khaleel S.A., Goudswaard J. and Virella G. (1977) Immunol. Commun. 6: 683.Google Scholar
  8. 8.
    Halsey J.F., Johnson B.H. and Cebra J.J. (1980) J. Exp. Med. 151: 767.PubMedCrossRefGoogle Scholar
  9. 9.
    Walker W.A. and Isselbacher K.J. (1977) New Eng. J. Med. 297: 767.PubMedCrossRefGoogle Scholar
  10. 10.
    Halsey J.F. and Benjamin D.C. (1976) J. Immunol. 116: 1204.PubMedGoogle Scholar
  11. 11.
    Abrahamson D.R., Powers A. and Rodewald R. (1979) Science 206: 567.PubMedCrossRefGoogle Scholar
  12. 12.
    Ancre C., Heremans J.F., Vaerman J-P. and Cambiaso C.L. (1975) J. Exp. Med. 142: 1509.CrossRefGoogle Scholar
  13. 13.
    Stokes C.R., Swarbrick E.T. and Soothill J.F. (1980) Immunol. 40: 455.Google Scholar
  14. 14.
    Bienenstock J, Johnston H. and Perey D.Y.E. (1973) Lab. Invest. 28: 686.PubMedGoogle Scholar
  15. 15.
    Bienenstock J. Johnston N. and Perey D.Y.E. (1973) Lab. Invest. 28: 693.PubMedGoogle Scholar
  16. 16.
    Ham A.W. (1969) “Histology” Lipincott, New York, p. 313.Google Scholar
  17. 17.
    Rudzik 0., Clancy R.L., Perey D.Y.E., Day R.P. and Bienenstock J. (1975) J. Immunol. 114: 1599.Google Scholar
  18. 18.
    Hall J.G. and Smith M.E. (1970) Nature 226: 262.PubMedCrossRefGoogle Scholar
  19. 19.
    McDermott M.R. and Bienenstock J. (1979) J. Immunol. 122: 1892.PubMedGoogle Scholar
  20. 20.
    Weisz-Carrington P., Roux M.E., McWilliams M, PhillipsQuagliata J.M. and Lamm M.E. (1979) J. Immunol. 123: 1705.PubMedGoogle Scholar
  21. 21.
    Roux M.E., McWilliams M., Phillips-Quagliata J.M., Weisz-Carrington P. and Lamm M.E. (1977) J. Exp. Med. 146: 1311.PubMedCrossRefGoogle Scholar
  22. 22.
    Bienenstock J. (1974) Prog. Immunol. I I, 4: 197.Google Scholar
  23. 23.
    Goldblum R.M. Ahlstedt S, Carlsson B., Hanson L.A., Jodal V., Lidin-Janson G. and Sohl-Akerlund A. (1975) Nature 257: 797.PubMedCrossRefGoogle Scholar
  24. 24.
    Weisz-Carrington P., Roux M.E., McWilliams M., PhillipsQuagliata J.M. and Lamm M.E. (1978) Proc. Nat. Acad. Sci. USA 75: 2928.CrossRefGoogle Scholar
  25. 25.
    McDermott M.R., Clark D.A. and Bienenstock J. (1980) J. Immunol. 124: 2536.PubMedGoogle Scholar
  26. 26.
    McDermott M.R., Heatly V., Befus A.D. and Bienenstock H. (1980) J. Cell. Immunol. (in press).Google Scholar
  27. 27.
    Pierce N.F. and Gowans J.L. (1975) J. Exp. Med. 142: 1550.PubMedCrossRefGoogle Scholar
  28. 28.
    Jacobson L.O., Marks E.K., Simmons E.L. and Gaston E.O. (1961) Proc. Soc. Exp. Biol. Med. 108: 487.Google Scholar
  29. 29.
    Gerbrandy J.L.F. and Bienenstock J. (1976) J. Immunol. 31: 913.Google Scholar
  30. 30.
    Durkin H.G. and Waksman B.H. (1979) Fed. Proc. 38: 1081Google Scholar
  31. 31.
    Ferguson A. (1977) Gut 18: 921.PubMedCrossRefGoogle Scholar
  32. 32.
    Guy-Grand D., Griscelli C. and Vassalli P. (1978) J. Exp. Med. 148: 1661.PubMedCrossRefGoogle Scholar
  33. 33.
    Kagnoff M.F. (1978) J. Immunol. 120: 395.PubMedGoogle Scholar
  34. 34.
    Frederick G.T. and Bohl E.G. (1976) J. Immunol. 116: 1000.PubMedGoogle Scholar
  35. 35.
    Henney C.S. and Waldmann R.H. (1970) Science 169: 696.PubMedCrossRefGoogle Scholar
  36. 36.
    Parmely M.J., Reath D.B., Beer A.E. and Billingham R.E. (1977) Transplantation Proc. 9: 1477.Google Scholar
  37. 37.
    Lefevre ME.E., Hammer R. and Joel D.D. (1979) J. Reticuloend. Soc. 26: 553.Google Scholar
  38. 38.
    Challacombe S., Krco C.J., David C.S. and Tomasi T.B. (1980) (submitted).Google Scholar
  39. 39.
    Gearhart G.J. and Cebra J.J. (1979) J. Exp. Med. 149: 216.PubMedCrossRefGoogle Scholar
  40. 40.
    Macpherson G.G. and Steer H.W. (1979) in “Function and Structure of the Immune System”, ed. Muller-Bucholtz W. and MullerHermelink, Plenum Press, New York, p. 433.Google Scholar
  41. 41.
    Falchuk K.R., Walker W.A., Perrott J.L. and Isselbacher K.J. (1977) Infect. Immun. 17: 361.PubMedGoogle Scholar
  42. 42.
    Svennerh.olm A-M., Holmgren J., Hanson L.A., Lindblad B.S. Quereshi F. and Rahimtoola R-J. (1977) Scand. J. Immunol. 6: 1345.Google Scholar
  43. 43.
    Lawrence G., Shann F., Freestone D.S. and Walker P.D. (1979) Lancet 1: 227.PubMedCrossRefGoogle Scholar
  44. 44.
    Sturn B. and Schneweis K.E. (1978) Med. Microbiol. Immunol. 165: 119.PubMedCrossRefGoogle Scholar
  45. 45.
    Nichols R.L., Murray E.S. and Nisson P.E. (1978) J. Infect. Dis. 138: 742.PubMedCrossRefGoogle Scholar
  46. 46.
    Swarbrick E.T., Stokes C.R. and Soothill J.F. (1979) Gut 20: 121.PubMedCrossRefGoogle Scholar
  47. 47.
    Pierce N.F. and Koster F.T. (1980) J. Immunol. 124: 307.PubMedGoogle Scholar
  48. 48.
    Parker D. and Turk J.L. (1978) Int Arch. Allergy Appl. Immun. 57: 289.CrossRefGoogle Scholar
  49. 49.
    Asherson G.L., Zembala M., Pereira M.A.C.C., Mayhew B. and Thomas W.R. (1977) Cell. Immunol. 33: 145.PubMedCrossRefGoogle Scholar
  50. 50.
    Mattingly J.A., Eardley D.D., Kemp J.D. and Gershon R.K. (1979) J. Immunol. 122: 787.PubMedGoogle Scholar
  51. 51.
    Mattingly J.A. and Waksman B.H. (1978) J. Immunol. 121: 1878.PubMedGoogle Scholar
  52. 52.
    Chalon M.P., Milne R.W. and Vaerman J-P. (1979) Eur. J. Immunol. 9: 747.PubMedCrossRefGoogle Scholar
  53. 53.
    Nagan J. and Kind L.S. (1978) J. Immunol. 120: 861.Google Scholar
  54. 54.
    Amsden A., Ewan V., Yoshida T. and Cohen S. (1978) J. Immunol. 122: 838.Google Scholar
  55. 56.
    McGhee J.R., Kiyono H., Michalek S.M., Babb J.L., Rosenstrei Rosenstreich D.L. and Mergenhagen S.E. (1980) J. Immunol. 124: 1603.PubMedGoogle Scholar
  56. 57.
    Pittard, W.B. and Bill K. (1979) Cell. Immunol. 42: 437.PubMedCrossRefGoogle Scholar
  57. 58.
    Hoerlein A.B. (1957) J. Immunol. 78: 112.PubMedGoogle Scholar
  58. 59.
    Jarrett E.E.E. and Hall E. (1979) Nature 280: 145.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • John Bienenstock
    • 1
  1. 1.Host Resistance Programme & Department of PathologyMcMaster University Health Sciences CentreHamiltonCanada

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