Cell Growth pp 773-798 | Cite as

Cell Kinetics in Clinical Oncology

  • Barthel Barlogie
  • Benjamin Drewinko
  • Martin N. Raber
  • Douglas E. Swartzendruber
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 38)


While the etiology of most human cancers is still unknown and may be multifactorial, a number of epiphenomena discriminating normal from malignant cells have been discovered, including genetic (1, 2), biochemical (3, 4, 5), and cytokinetic parameters (6, 7). Focusing on the kinetics of tumor growth in this chapter, we will: (1) delineate how measurements of cell kinetics parameters can serve as quantitative descriptors of malignant disease potentially determining response to cytotoxic therapy; (2) review strategies to either differentially enhance tumor cell kill or to establish a viable symbiosis between tumor and host via tumor cell differentiation; and (3) address the feasibility of cytokinetic methods to predict drug responsiveness in vitro and in vivo.


Labelling Index Acute Leukemia Acridine Orange Cell Kinetics Tritiated Thymidine 


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Barthel Barlogie
    • 1
  • Benjamin Drewinko
    • 1
  • Martin N. Raber
    • 1
  • Douglas E. Swartzendruber
    • 1
  1. 1.The University of Texas System Cancer CenterM.D. Anderson Hospital and Tumor InstituteHoustonUSA

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