Advertisement

Cell Growth pp 673-714 | Cite as

Molecular Mechanisms of the Control of Cell Growth in Cancer

  • Arthur B. Pardee
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 38)

Abstract

Most cells in vivo are in a quiescent state. They metabolize and perform various functions. In adults they do not generally divide unless they are to be replaced. Some cells practically never divide (brain cells) or are terminally differentiated and cannot divide (red cells). Others divide quite frequently (skin, intestine, bone marrow cells); some divide after an insult such as wounding. Cells thus contain regulatory mechanisms that control their capacity to divide.

Keywords

Nude Mouse Restriction Point Thymidine Kinase Growth Control Picolinic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    J. Poten, Biochem. Biophys. Acta, 458: 397 (1976).Google Scholar
  2. 2.
    H.C. Pitot, “Fundamentals of Oncology”, Marcel Dekker, Inc. N.Y. (1978).Google Scholar
  3. 3.
    B. Clarkson and R. Baserga (ed.) “Control of Proliferation in Animal Cells”, Cold Spring Harbor, New York (1974).Google Scholar
  4. 4.
    R. Baserga, “Multiplication and Division of Mammalian Cells” Marcel Dekker, Inc., N.Y. (1976).Google Scholar
  5. 5.
    D.M. Prescott, “Reproduction in Eukaryotic Cells”, Academic Press, N.Y. (1976).Google Scholar
  6. 6.
    A.B. Pardee, R. Dubrow, J. Hamlin and R.F. Kletzein, Ann. Rev. Biochem., 47: 715 (1978).PubMedCrossRefGoogle Scholar
  7. 7.
    V.R. Potter, Br. J. Cancer, 38: 1 (1978).PubMedCrossRefGoogle Scholar
  8. 8.
    A. Schmid, D.J. Hutchinson, G.M. Otter and C.C. Stock, Cancer Treatment Reports, 60: 23 (1976).PubMedGoogle Scholar
  9. 9.
    G. Weber, New England J. Med., 296:486 & 541 (1977).Google Scholar
  10. 10.
    C.B. Stiles and A. Kawahara, in: The Nude Mouse in Experimental and Clinical Research, J. Fogh and B. Giovanella, editors, Academic Press, N.Y. (1978).Google Scholar
  11. 11.
    A.B. Pardee and L.J. James, Proc. Natl. Acad. Sci. USA, 72: 4994 (1975).CrossRefGoogle Scholar
  12. 12.
    O.I. Epifanova, Int. Rev. Cytol., 49 (Suppl): 303 (1977).Google Scholar
  13. 13.
    S. Gelfant, Cancer Res., 37: 3845 (1977).PubMedGoogle Scholar
  14. 14.
    C. Nicolini, F. Kendall, C. Desaive, B. Clarkson and J. Fried, Cancer Treatment Rep., 60: 1818–27 (1976).Google Scholar
  15. 14a.
    C. Nicolini, S. Parodi, A. Belmont, S. Abraham and S. Lessin, J. Histoch. Cytochem., 27: 102–113 (1979).CrossRefGoogle Scholar
  16. 14b.
    Z. Darzynkiewica, D.P. Evenson, L. Staiano-Coico, T. Sharpless, and M.R. Melamed, J. Cell. Physiol., 100: 425 (1979).CrossRefGoogle Scholar
  17. 14c.
    C. Nicolini, F. Kendall, C. Desaive and W. Giarretti, Expt. Cell Res., 106: 118–127 (1977).Google Scholar
  18. 15.
    A. Yen, R. Warrington, A.B. Pardee, Exp. Cell Res., 114: 458 (1978).PubMedCrossRefGoogle Scholar
  19. 16.
    V.G.H. Riddle, P. Rossow, R. Boorstein, M. Addonizio, and A.B. Pardee, in: “The Molecular Base of Immune Cell Function”, J.C. Kaplan, editor, Elsevier/North Holland, Amsterdam (1979).Google Scholar
  20. 17.
    C.S. Sher, W.J. Pledger, P. Martin, H. Antoniades, and C. D. Stiles, J. Cell Physiol, 97: 371 (1978).CrossRefGoogle Scholar
  21. 18.
    B.T. Hill, Biochem. Biophys. Acta., 516: 3879 (1978).Google Scholar
  22. 19.
    A. Yen and A.B. Pardee, Exp. Cell Res., 116: 103 (1978).PubMedCrossRefGoogle Scholar
  23. 20.
    R.F. Brooks, Cell, 12: 311 (1977).PubMedCrossRefGoogle Scholar
  24. 21.
    A.B. Pardee, Proc. Natl. Sci., USA, 71: 1286 (1974).CrossRefGoogle Scholar
  25. 22.
    H. Rubin and R. Steiner, J. Cell Physiol., 85: 261 (1975).PubMedCrossRefGoogle Scholar
  26. 23.
    J.A. Smith, and L. Martin, Proc. Natl. Sci. Acad. USA, 70: 1263 (1973).CrossRefGoogle Scholar
  27. 24.
    H.M. Temin, J. Cell. Physiol., 78: 161 (1971).PubMedCrossRefGoogle Scholar
  28. 25.
    L. Augenlicht and R. Baserga, Exp. Cell Res., 89: 255 (1974).PubMedCrossRefGoogle Scholar
  29. 26.
    D.D. Cunningham and A.B. Pardee, Proc. Natl. Sci. Acad. USA, 64: 1049 (1970).CrossRefGoogle Scholar
  30. 27.
    A. Hershko, P. Mamont, R. Shields, and G.M. Tomkins, Nature New Biol., 232: 206 (1971).PubMedGoogle Scholar
  31. 28.
    L.H. Hartwell, Bacterid. Revs., 38: 164 (1974).Google Scholar
  32. 29.
    J. Mandelstam and S.A. Higgs, J. Bacterid., 120: 38 (1974).Google Scholar
  33. 30.
    B. Shilo, V. Shilo, and G. Simchen, Nature, 264: 767 (1976).PubMedCrossRefGoogle Scholar
  34. 31.
    J.E. Sisken and L. Morasca, J. Cell. Biol., 25: 179 (1965).PubMedCrossRefGoogle Scholar
  35. 32.
    G. Sander, and A.B. Pardee, J. Cell. Physiol., 80: 267 (1972).PubMedCrossRefGoogle Scholar
  36. 33.
    K.D. Ley and R.A. Robey, J. Cell. Biol., 47: 453 (1970).PubMedCrossRefGoogle Scholar
  37. 34.
    D. Killander, and A. Zetterberg, Exp. Cell Res., 40: 12 (1965).PubMedCrossRefGoogle Scholar
  38. 35.
    T.O. Fox and A.B. Pardee, Science, 167: 80 (1970).PubMedCrossRefGoogle Scholar
  39. 36.
    A. Yen, J. Fried, T. Kerahara, A. Strife and B.D. Clarkson, Exp. Cell Res., 95: 303 (1975).PubMedCrossRefGoogle Scholar
  40. 37.
    R.F. Brooks, D.C. Bennett, and J.A. Smith, Cell, 19: 493 (1980).PubMedCrossRefGoogle Scholar
  41. 38.
    A.B. Pardee, B. Shilo and A. Koch, in: “Hormones and Cell Culture”, Cold Spring Harbor, N.Y., p. 373 (1979).Google Scholar
  42. 38a.
    C. Nicolini, Cell Biophysics, Vol. 2, Number 3, 1–10 (1980).Google Scholar
  43. 39.
    R.G. Martin and S. Stein, Proc. Natl. Acad. Sci. USA, 73: 1655 (1976).CrossRefGoogle Scholar
  44. 40.
    R.W. Holley, Nature, 258: 487 (1975).PubMedCrossRefGoogle Scholar
  45. 41.
    B.K. Bhuyan and T.J. Fraser, Cancer Res., 34: 778 (1974).PubMedGoogle Scholar
  46. 42.
    G.P. Studzinski and J.F. Gierthy, J. Cell Physiol., 81: 71 (1973).PubMedCrossRefGoogle Scholar
  47. 43.
    J.C. Bartholomew, H. Yokota and P. Ross, J. Cell. Physiol., 88: 277 (1976).PubMedCrossRefGoogle Scholar
  48. 44.
    D. Paul, Biochem. Biophys. Res. Commun., 35: 3111 (1973).Google Scholar
  49. 45.
    M.O. Bradley, K.W. Kohn, N.A. Sharkey and R.A. Ewig, Cancer Res., 37: 2126 (1977).PubMedGoogle Scholar
  50. 46.
    E. Rozengurt and C.C. Po, Nature, 261: 701 (1976).PubMedCrossRefGoogle Scholar
  51. 47.
    J.M. Vasiliev, I.M. Gelfand, V.I. Guelstein and A.G. Malenkov, Int. J. Cancer, 1: 451 (1966).PubMedCrossRefGoogle Scholar
  52. 48.
    W.C. Dewey, H.H. Miller, and H. Nagasawa, Exp. Cell Res., 77: 78 (1973).CrossRefGoogle Scholar
  53. 49.
    C.F. Graham, J. Cell Sci., 1: 363 (1966).PubMedGoogle Scholar
  54. 50.
    S. Gordon and Z. Cohen, J. Exp. Med., 134: 935 (1971).PubMedCrossRefGoogle Scholar
  55. 51.
    P. Rao and R. Johnson, Nature, 225: 159 (1970).PubMedCrossRefGoogle Scholar
  56. 52.
    J. Tyson, G. Garcia-Herdugo, and W. Sachsenmaier, Exp. Cell Res., 119: 87Google Scholar
  57. 53.
    F.J. O’Neill, Cancer Res., 34: 107 (1974).Google Scholar
  58. 54.
    M.H. Schneiderman, W.C. Dewey and D.P. Highfield, Exp. Cell Res., 67: 147 (1971).PubMedCrossRefGoogle Scholar
  59. 55.
    C. Basilico, Adv. Cancer Res., 24: 223 (1977).PubMedCrossRefGoogle Scholar
  60. 56.
    P. Rossow, V.G.H. Riddle, A.B. Pardee, Proc. Natl. Acad. Sci., 76: 4446 (1979).CrossRefGoogle Scholar
  61. 57.
    B.K. Choe and N.R. Rose, Exp. Cell Res., 83: 271 (1974).PubMedCrossRefGoogle Scholar
  62. 58.
    T.O. Fox and A.B. Pardee, J. Biol. Chem., 246: 6159 (1971).PubMedGoogle Scholar
  63. 59.
    L.G. Gudas, R. James and A.B. Pardee, J. Biol. Chem., 231: 3470 (1976).Google Scholar
  64. 60.
    K.D. Ley, J. Cell Biol., 66: 95 (1975).PubMedCrossRefGoogle Scholar
  65. 61.
    V. G.H. Riddle, R. Dubrow and A.B. Pardee, Proc. Natl. Acad. Sci. USA, 76: 1298 (1979).CrossRefGoogle Scholar
  66. 62.
    E. W. Gerner, R.E. Meyn, and R.M. Humphrey, J. Cell Physiol. 87: 277 (1976).PubMedCrossRefGoogle Scholar
  67. 63.
    L. I. Rebhun, Int. Rev. Cytol., 49: 1 (1977).PubMedCrossRefGoogle Scholar
  68. 64.
    E. Rapaport and P.C. Zamecnik, Proc. Natl. Acad. Sci. USA, 73: 3984 (1976).CrossRefGoogle Scholar
  69. 65.
    F. Grummt, G. Waltl, H. Jantzen, K. Hamprecht, U. Heubscher, and C.C. Kuenzle, Proc. Natl. Acad. Sci., USA, 76: 6081 (1979).CrossRefGoogle Scholar
  70. 66.
    K. Kumar and D. Friedman, Nature New Biol., 239: 74 (1972).PubMedGoogle Scholar
  71. 67.
    L. Thompson and B. McCarthy, Biochem. Biophys. Res. Comm., 30: 166 (1968).CrossRefGoogle Scholar
  72. 68.
    L. Thompson and B. McCarthy, Fed. Proc., 30: Abst. 1177 (1971).Google Scholar
  73. 69.
    S. Planck, S. Seki, M. LeMahieu and G.C. Mueller, Fed. Proc., 33: Abst. 303 (1974).Google Scholar
  74. 70.
    S. M. Jazwinski and G.M. Edelman, Proc. Natl. Acad. Sci. USA, 73: 3933 (1976).CrossRefGoogle Scholar
  75. 71.
    H. Krokan, L.A. Cooke and H. Prydz, Biochem., 14: 4233 (1975).CrossRefGoogle Scholar
  76. 72.
    M. Goulian and B.Y. Tseng, J. Mol. Biol., 99: 317 (1975).PubMedCrossRefGoogle Scholar
  77. 73.
    H. V. Hershey and I. Taylor, Exp. Cell Res., 85: 79 (1974).PubMedCrossRefGoogle Scholar
  78. 74.
    D. L. Friedman, Biochem. Biophys. Acta, 353: 447 (1974).Google Scholar
  79. 75.
    L. H. Lazarus, F.E.B.S. Letters, 35: 166 (1973).CrossRefGoogle Scholar
  80. 76.
    A. Klein and F. Bonhoeffer, Ann. Rev. Biochem., 41: 301 (1972)PubMedCrossRefGoogle Scholar
  81. 77.
    S. Seki, M. Le Mahieu and G.C. Mueller, Biochem. Biophys. Acta, 378: 333 (1975).Google Scholar
  82. 78.
    D. Billen and A.C. Olson, J. Cell Biol., 69: 732 (1976).PubMedCrossRefGoogle Scholar
  83. 79.
    N. A. Berger and E.S. Johnson, Biochem. Biophys. Acta, 425: 1 (1976).Google Scholar
  84. 80.
    J. J. Castellot, Jr. in: “Introduction of Macromolecules into Viable Mammalian Cells” R. Baserga, S. Croce and G. Rovera, editors, Allen R. Liss, Inc., New York (1980).Google Scholar
  85. 81.
    S. Shin, V.H. Freedman, R. Risser and R. Pollack, Proc. Natl. Acad. Sci. USA, 72: 4435 (1975).CrossRefGoogle Scholar
  86. 82.
    C. Heidelberger, Ann. Rev. Biochem., 44: 79 (1975).PubMedCrossRefGoogle Scholar
  87. 83.
    J. Tooze, The Molecular Biology of Tumor Viruses, Cold Spring Harbor, N.Y. (1973).Google Scholar
  88. 84.
    A. Smets, Biochem. Biophys. Acta. 605: 93 (1980).Google Scholar
  89. 85.
    E. S. Stanbridge, and J. Wilkinson, Proc. Natl. Acad. Sci. USA, 75: 1466 (1978).CrossRefGoogle Scholar
  90. 86.
    V. H. Freedman and S. Shin, Cell, 3: 355 (1974).PubMedCrossRefGoogle Scholar
  91. 87.
    C. B. Stiles, W. Desmond, L.H. Chuman, G. Sato and M.H. Saier, Jr., Cancer Res., 36: 3300 (1976).PubMedGoogle Scholar
  92. 88.
    C. B. Stiles, L.M. Chuman and M.H. Saier, Jr., J. Cell Biol., 70: 169a (1976).Google Scholar
  93. 89.
    R. Sager and P. Kovac, Somatic Cell Genet., 4: 375 (1978).PubMedCrossRefGoogle Scholar
  94. 90.
    H. Eagle, G.E. Foley, H. Koprowski, H. Lazarus, E.M. Levine and R.A. Adams, J. Exp. Med., 131: 863 (1970).PubMedCrossRefGoogle Scholar
  95. 91.
    R.W. Tucker, K.K. Sanford, S.L. Handleman and G.M. Jones, Cancer Res., 37: 1571 (1977).PubMedGoogle Scholar
  96. 92.
    I. MacPherson and L. Montagnier, Virology, 23: 291 (1964).PubMedCrossRefGoogle Scholar
  97. 93.
    T. Kuroki, Meth. Cell Biol., 9: 157 (1975).CrossRefGoogle Scholar
  98. 94.
    J. Folkman and A. Moscona, Nature, 273: 345 (1978).PubMedCrossRefGoogle Scholar
  99. 95.
    R. Kitchen and R. Sager, Somatic Cell Genet., (In Press)Google Scholar
  100. 96.
    J.A. Di Paolo, K. Takano, and N.C. Popescu, Cancer Res., 32: 2686 (1972).Google Scholar
  101. 97.
    N. Bouck, and G. diMayorca, Nature, 264: 722 (1976).PubMedCrossRefGoogle Scholar
  102. 98.
    C.A. Reznikoff, D.W. Brankow and C. Heidelberger, Cancer Res., 33: 3231 (1973).PubMedGoogle Scholar
  103. 99.
    J.C. Barrett and P.O.P. Ts’o, Proc. Natl. Acad. Sci. USA, 75: 3761 (1978).CrossRefGoogle Scholar
  104. 100.
    B.N. Ames, J. McCann and E. Yamasaki, Mutation Res., 31: 347 (1975).PubMedGoogle Scholar
  105. 101.
    E. Huberman, P.J. Donovan and J.A. Di Paolo, J. Nat. Cancer Inst. 48: 837 (1972).PubMedGoogle Scholar
  106. 102.
    J.C. Barrett and P.O.P. Ts’o, Proc. Natl. Acad. Sci. USA, 75: 3297 (1978).CrossRefGoogle Scholar
  107. 103.
    I. Berenblum; Cancer Res., 14: 471 (1954).PubMedGoogle Scholar
  108. 104.
    S. Mondal, D.W. Brankow and C. Heidelberger, Cancer Res., 36: 2254 (1976).PubMedGoogle Scholar
  109. 105.
    V.H. Freedman and S. Shin, J. Nat. Cancer Inst., 58: 1873 (1977).PubMedGoogle Scholar
  110. 106.
    T. Kakunaga, Proc. Natl. Acad. Sci. USA, 75: 1334 (1978).PubMedCrossRefGoogle Scholar
  111. 107.
    G.E. Milo, Jr. and J.A. Di Paolo, Nature, 275: 130 (1978).PubMedCrossRefGoogle Scholar
  112. 108.
    National Academy of Science USA Report, “Particulate Polycyclic Organic Matter”, Washington, D.C. (1972).Google Scholar
  113. 109.
    J.A. Di Paolo, R.L. Nelson and P.J. Donovan, Science, 165: 917 (1969).CrossRefGoogle Scholar
  114. 110.
    E. Huberman, S.L. Sach, S.K. Yang, H.V. Gelboin, Proc. Natl. Acad. Sci. USA, 73: 607 (1976).CrossRefGoogle Scholar
  115. 111.
    S.K. Yang, D.W. McCourt, P.P. Rollec, H.V. Gelboin, Proc. Natl. Acad. Sci. USA, 73: 2594 (1976).CrossRefGoogle Scholar
  116. 112.
    T. Meehan and K. Straub, Nature, 277: 410 (1979).PubMedCrossRefGoogle Scholar
  117. 113.
    S. Kimura, V.L. Flannery, B. Levy, and P. Schaffer, Int. J. Cancer, 15: 786 (1975).PubMedCrossRefGoogle Scholar
  118. 114.
    G.M. Cooper and H.M. Temin, Cold Spring Harbor Symp. 39: 1027 (1975).CrossRefGoogle Scholar
  119. 115.
    W.B. Pratt and R.W. Ruddon, “The Anticancer Drugs” Oxford Univ. Press (1979).Google Scholar
  120. 116.
    W. Sutow, J. Vietti and D.J. Fernback (Editors) “Clinical Pediatric Oncology”, Chapters 5 and 6, St. Louis, The C.V. Mosby Company (1973).Google Scholar
  121. 117.
    M. Israel, J. Modest and E. Frei, III, Cancer Res., 35: 1365 (1975).PubMedGoogle Scholar
  122. 118.
    E. Frei, III, Cancer Res., 32: 2593 (1972).PubMedGoogle Scholar
  123. 119.
    G.L. Nicolson, Biochem. Biophys. Acta, 457: 57 (1976).Google Scholar
  124. 120.
    G.L. Nicolson, Biochem. Biophys. Acta, 458: 1 (1976).Google Scholar
  125. 121.
    A.B. Pardee, Biochem. Biophys. Acta, 417: 153 (1975).Google Scholar
  126. 122.
    A.B. Pardee, Nat. Cancer Inst. Monograph, 14: 7 (1964).Google Scholar
  127. 123.
    P.S. Rudland and L. Jimenez de Asua, Biochem. Biophys. Acta, 550: 91 (1979).Google Scholar
  128. 124.
    D. Gospodarowicz and J.S. Moran, Ann. Rev. Biochem., 45: 531 (1977).CrossRefGoogle Scholar
  129. 125.
    I. Hayashi and G. Sato, Nature, 259: 132 (1976).PubMedCrossRefGoogle Scholar
  130. 126.
    A. Rizzino and G. Sato, Proc. Natl. Acad. Sci. USA, 75: 1844 (1978).CrossRefGoogle Scholar
  131. 127.
    K. Mierzejewski and E. Rozengurt, Biochem. Biophys. Res. Commun., 73: 271 (1976).CrossRefGoogle Scholar
  132. 128.
    H. Bush and M. Shodell, J. Cell Physiol., 90: 573 (1977).PubMedCrossRefGoogle Scholar
  133. 129.
    P.V. Cherington, B. Smith and A.B. Pardee, Proc. Natl. Acad. Sci. USA, 76: 3937 (1979).CrossRefGoogle Scholar
  134. 130.
    G. Carpenter and S. Cohen, J. Cell Biol., 71: 159 (1976).PubMedCrossRefGoogle Scholar
  135. 131.
    J.E. DeLarco and G.J. Todaro, J. Cell Physiol., 94: 33 (1978).Google Scholar
  136. 132.
    M.D. Hollenberg and P. Cuetrecaras, J.Biol. Chem., 250: 3845 (1975).PubMedGoogle Scholar
  137. 133.
    M. Das, T. Miyakawa, C.F. Fox, R.M. Pruss, A. Aharonov and H. R. Herchman, Proc. Natl. Acad. Sci. USA, 74: 2790 (1977).CrossRefGoogle Scholar
  138. 134.
    Y. Shechter, L. Hernaez and P. Cuatrecuras, Proc. Natl. Acad. Sci. USA, 75: 5788 (1978).CrossRefGoogle Scholar
  139. 135.
    M. Das, Proc. Natl. Acad. Sci. USA, 77: 122 (1980).CrossRefGoogle Scholar
  140. 136.
    P. Greengard, Science, 199: 146 (1978).PubMedCrossRefGoogle Scholar
  141. 137.
    R.A. Jungmann and D.H. Russell, Life Sciences, 20:1787 (1977),Google Scholar
  142. 138.
    C.W. MacKenzie, III and R.H. Stellwagen, J. Biol. Chem. 249: 5755 (1974).PubMedGoogle Scholar
  143. 139.
    P. Coffino, H.R. Bourne, U. Friedrich, J. Hochman, P.A. Insel, I. LeMaire, K.L. Melmon, and G.M. Tomkins, Recent Progress Hormone Res., 32: 669 (1976).Google Scholar
  144. 140.
    R. Simantov and L. Sachs, J. Biol. Chem., 250: 3236 (1975).PubMedGoogle Scholar
  145. 141.
    R. Simantov and L. Sachs, Eur. J. Biochem., 59: 89 (1975).PubMedCrossRefGoogle Scholar
  146. 142.
    N.M. Wigglesworth, A. Mastro, H.R. Bourne, and E. Rozengurt, Arch. Biochem. Biophys., 180: 258 (1977).PubMedCrossRefGoogle Scholar
  147. 143.
    A.J. Gharrett, A.M. Malkinson and J.R. Sheppard, Nature, 264: 673 (1976).PubMedCrossRefGoogle Scholar
  148. 144.
    A.D. Levinson, H. Oppermann, L. Levintow, H.E. Varmus, and J.M. Bishop, Cell, 15: 561 (1978).PubMedCrossRefGoogle Scholar
  149. 145.
    R.F. Kletzien, M.R. Miller and A.B. Pardee, Nature, 270: 57 (1977).PubMedCrossRefGoogle Scholar
  150. 146.
    M. Costa, E.W. Gerner and D.H. Russell, J. Biol. Chem., 251: 3313 (1976).PubMedGoogle Scholar
  151. 147.
    M. Costa, E.W. Gerner and D.H. Russell, Biochem. Biophys. Acta, 538: 1 (1978).CrossRefGoogle Scholar
  152. 148.
    J. Karn, E.M. Johnson, G. Vidali and V. Allfrey, J. Biol. Chem., 249: 667 (1974).PubMedGoogle Scholar
  153. 149.
    G. Carpenter, L. King, Jr., and S. Cohen, Nature, 276: 409 (1978).PubMedCrossRefGoogle Scholar
  154. 150.
    J.J. Castellot, Jr., M. Miller and A.B. Pardee, Proc. Natl. Acad. Sci. USA, 75: 351 (1958).CrossRefGoogle Scholar
  155. 151.
    P.V. Reddy and A.B. Pardee, Proc. Natl. Acad. Sci. USA, 76: 0000 (1980).Google Scholar
  156. 152.
    R.W. Hoiley, J.H. Baldwin, J.A. Kiernan and T.O. Messmer, Proc. Natl. Acad. Sci. USA, 73: 3229 (1976).CrossRefGoogle Scholar
  157. 153.
    H.L. Moses, J.A. Proper, M.E. Volkenant, D.J. Well and M.J. Getz, Cancer Res., 38: 2807 (1978).PubMedGoogle Scholar
  158. 154.
    F.J. O’Neill, Exp. Cell Res., 117: 393 (1978).PubMedCrossRefGoogle Scholar
  159. 155.
    F.J. O’Neill, Cancer Res., 35: 3111 (1975).PubMedGoogle Scholar
  160. 156.
    J.A. Fernandez-Pol, V.H. Bono, Jr. and G.S. Johnson, Proc. Natl. Acad. Sci. USA, 74: 2889 (1977).CrossRefGoogle Scholar
  161. 157.
    L. Mallucci, G.H. Poste and V. Wells, Nature New Biol., 235: 222 (1972).PubMedCrossRefGoogle Scholar
  162. 158.
    L. Mallucci, V. Wells and M.R. Young, Nature New Biol., 239: 53 (1972).PubMedCrossRefGoogle Scholar
  163. 159.
    R. Dubrow, V.G.H. Riddle and A.B. Pardee, Cancer Res., 39: 2718 (1979).PubMedGoogle Scholar
  164. 160.
    Cherington, P.V. and Pardee, A.B. (1980) J. Cell Physiol. 105: 25–32.PubMedCrossRefGoogle Scholar
  165. 161.
    Pardee, A.B. Cherington, P.V. and Medrano, E.E. (1980) ICN-UCLA Sumposium on Control of Cell Division and Development. in press.Google Scholar
  166. 162.
    Riddle, V.G.H. and Pardee, A.B (1980) J. Cellular Physiol. 103: 11–15CrossRefGoogle Scholar
  167. 163.
    Riddle, V.G.H., Pardee, A.B. and Rossow, P. (1979) J. Supromolecular Structure. 11: 529–538.CrossRefGoogle Scholar
  168. 164.
    Shilo, B., Simchen, G. and Pardee, A.B. (1978) J. Cell Physiol. 97: 177–188.PubMedCrossRefGoogle Scholar
  169. 165.
    Shilo, B., Riddle, V.G.H. and Pardee, A.B. (1979) Exp. Cell Res. 123: 221–227.PubMedCrossRefGoogle Scholar
  170. 166.
    Medrano, E.E., and Pardee, A.B. (1980) Proc. Natl. Acad. Sci. U.S.A. 77: 4123–4126.PubMedCrossRefGoogle Scholar
  171. 167.
    Yen, A. and Pardee, A.B. (1979) Science 204: 1315–1317.PubMedCrossRefGoogle Scholar
  172. 168.
    Tucker, R., Pardee, A.B. and Fujiward, K. (1979) Cell 17: 527–535.PubMedCrossRefGoogle Scholar
  173. 169.
    Hamlin, J.L. and Pardee, A.B. (1978) in Vitro 14: 119–127.Google Scholar
  174. 170.
    Fansler, B. and Loeb, L.A. (1969) Exp. Cell Res. 57: 305-Google Scholar
  175. 171.
    Mitchison, J.M. (1971). The Biology of The Cell Cycle ( London: Cambridge U. Press).Google Scholar
  176. 172.
    Brezney, R. and Coffey, D.S. (1977). J. Cell Biol. 73: 616CrossRefGoogle Scholar
  177. 173.
    Miller, M.F., Castellot Jr., J.J. and Pardee, A.B. (1978) Biochemistry 17: 1073–1080.PubMedCrossRefGoogle Scholar
  178. 174.
    Castellot Jr., J.J., Miller, M.R. and Pardee, A.B. (1978) Proc. Natl. Acad. Sci. U.S.A. 75: 351–355.PubMedCrossRefGoogle Scholar
  179. 175.
    Miller, M., Castellot Jr., J.J. and Pardee, A.B. (1979) Exp. Cell Res. 120: 421–426.PubMedCrossRefGoogle Scholar
  180. 176.
    Castellot Jr., J.J., Miller, M., Lehtomaki, D. and Pardee, A.B. (. 1979 ) J. Biol. Chem. 254: 6904–6908.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Arthur B. Pardee
    • 1
    • 2
  1. 1.Department of PharmacologyHarvard Medical SchoolUSA
  2. 2.Laboratory of Tumor BiologySidney Farber Cancer InstituteBostonUSA

Personalised recommendations