Cell Growth pp 653-671 | Cite as

Cell Transformation by RNA Sarcoma Virus

  • Heinz Bauer
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 38)


Autonomous cell proliferation appears to be an essential characteristic of most neoplastic cells. Present knowledge of the biochemical and biological properties by which the phenotype of tumor cells may be defined, is largely based on experimental studies in vitro, in which normal cells are converted to a transformed state by virus infection. This transformed state in vitro appears to correlate with the phenotype of tumor cells in vivo. Numerous viruses with the capacity to transform cells have been identified and genetic analyses have revealed that many of these bear genetic information, generally referred to as an onc-gene, which is directly responsible for transformation. These viral onc-genes have proven to be powerful tools in the study of the molecular processess which initiate and maintain malignant cell growth (see CSH Symp. 44, 1980).


Cell Transformation Cell Surface Antigen Rous Sarcoma Virus Chick Embryo Fibroblast Oncofetal Antigen 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Heinz Bauer
    • 1
  1. 1.Institut für VirologieJustus-Liebig-UniversitätGiessenDeutschland

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