Cell Growth pp 575-585 | Cite as

Cell Conformation and Growth Control

  • Scott Wittelsberger
  • Judah Folkman
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 38)


Studies on the control of growth of mammalian cells have focused primarily on the role of diffusible factors, in the promotion of cell growth. However, a number of experimental results in the last several years suggest that there is another level at which cell growth may be controlled. These studies show that cell conformation plays a crucial role in growth control. The term “conformation” as used here refers both to cell shape and to the nature of the cell-substratum interaction. The experimental studies which will be described here show that cell conformation has a profound influence on (a) cell growth; (b) RNA and protein metabolism; and (c) gene expression. Furthermore, the acquisition of the fully transformed or neoplastic phenotype appears to involve the loss of the conformational-related control of these processes.


Label Index Cell Shape Confluent Culture Diploid Fibroblast Untransformed Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Stocker, M., O’Neill, C., Berryman, S., and Waxman, V. (1968). Int. J. Canc. 3, 683–693.CrossRefGoogle Scholar
  2. 2.
    Otsuka, H. and Moskowitz, M (1975). J. Cell Phys. 87, 213–220.CrossRefGoogle Scholar
  3. 3.
    MacPherson, I. and Montagnier, L. (1964). Virology 23, 291–294.PubMedCrossRefGoogle Scholar
  4. 4.
    Freedman, V.H. and Shin, S. (1974). Cell 3: 355–359.PubMedCrossRefGoogle Scholar
  5. 5.
    Folkman, J. and Moscona, A. (1978). Nature 273, 345–349.PubMedCrossRefGoogle Scholar
  6. 6.
    Tucker, R. and Folkman, J. Unpublished observations.Google Scholar
  7. 7.
    Benecke, B.-J., Ben-Ze’ev, A. and Penman, S. (1978). Cell 14, 931–939.PubMedCrossRefGoogle Scholar
  8. 8.
    Benecke, B.-J., Ben-Ze’ev, A. and Penman, S. (1980). J. Cell Physiol. 103, 247–254.PubMedCrossRefGoogle Scholar
  9. 9.
    Ben-Ze’ev, A., Farmer, S.R. and Penman, S. (1980). Cell 21, 365–372.PubMedCrossRefGoogle Scholar
  10. 10.
    Glowacki, J., Trepman, E. and Folkman, J. (1981). In preparation.Google Scholar
  11. 11.
    Azizkhan, J. and Klagsburn, M. (1981). In preparation.Google Scholar
  12. 12.
    Wittelsberger, A. and Penman, S. (1981). Cell, in press.Google Scholar
  13. 13.
    Todaro, G. and Green, H. (1963). J. Cell Biol. 17, 299–313.PubMedCrossRefGoogle Scholar
  14. 14.
    Foulds, L. (1975). Neoplastic Development, Vol. 2, ( Academic Press, New York ).Google Scholar
  15. 15.
    Barrett, J.C. and Ts’O, P.O.P. (1978). Proc. Natl. Acad. Sci. USA 75, 3761–3765.CrossRefGoogle Scholar
  16. 16.
    Barrett, J.C. (1980). Cane. Res. 40, 91–94.Google Scholar
  17. 17.
    Abercrombe, M., Heaysman, J.E. and Pegrum, S.M. (1971). Exp. Cell Res. 59, 393–398.CrossRefGoogle Scholar
  18. 18.
    Couchman, J.R. and Rees, D.A. (1979). J. Cell Sci. 39, 149–165.PubMedGoogle Scholar
  19. 19.
    Lenk, R., Ransom, L., Kaufman, Y. and Penman, S. (1977). Cell 10, 67–78.PubMedCrossRefGoogle Scholar
  20. 20.
    Lenk, R. and Penman, S. (1979). Cell 16, 289, 301.Google Scholar
  21. 21.
    Cervera, M., Dreyfuss, G. and Penman, S. (1981). Cell, in press.Google Scholar
  22. 22.
    Otto, A.M., Zunbe, A., Gibson, L., Kubler, A.M. and De Asua, L.J. (1979), Proc. Natl. Acad. Sci. USA 76, 6435–6438.CrossRefGoogle Scholar
  23. 23.
    Friedkin, M., Legg, A. and Rozengurt, E. (1980). Exp. Cell Res. 129, 23–30.PubMedCrossRefGoogle Scholar
  24. 24.
    McClain, D.A., D’Eustachio, P. and Edelman, G.M. (1977). Proc. Natl. Acad. Sci. USA 74, 666–670.CrossRefGoogle Scholar
  25. 25.
    McClain, D.A. and Edelman, G.A. (1980). Proc. Natl. Acad. Sci. USA 77, 2748–2752.CrossRefGoogle Scholar
  26. 26.
    Schwartz, S.M. Selden, S.C. and Bowman, P. (1979). In Hormones and Cell Culture, eds. Sato, G.H. and Ross, R. Cold Spring Harbor Laboratory Press ), pp. 593–610.Google Scholar
  27. 27.
    Gospodarowicz, D. and Ill, C.R. (1980). Proc. Natl. Acad. Sci. USA 77, 2726–2730.CrossRefGoogle Scholar
  28. 28.
    Gospodarowicz, D., Delgado, D. and Vlodavsky, I. (1980) Proc. Natl. Acad. Sci. USA 77, 4094–4098.CrossRefGoogle Scholar
  29. 29.
    Chen, L.B., Summerhayes, I., Hsieh, P. and Gallimore, P.H. (1979). J. Supramolec. Struct. 14, 139–150.CrossRefGoogle Scholar
  30. 30.
    Emerman, J.T., Burwen, S.J. and Pitelka, D.R. (1979). Tissue and Cell 11, 109–119.PubMedCrossRefGoogle Scholar
  31. 31.
    Goldman, R.D., Yerna, M. and Scioso, J.A. (1976). J. Supramolec. Struct, 5, 155–183.CrossRefGoogle Scholar
  32. 32.
    Tucker, R.W., Sanford, K.K. and Frankel, F.R. (1978). Cell 13, 629–642.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Scott Wittelsberger
    • 1
    • 2
    • 3
    • 4
  • Judah Folkman
    • 1
    • 2
    • 3
    • 4
  1. 1.Department of SurgeryChildren’s Hospital Medical CenterUSA
  2. 2.Department of AnatomyHarvard Medical SchoolBostonUSA
  3. 3.Department of SurgeryHarvard Medical SchoolBostonUSA
  4. 4.Department of BiologyMassachusetts Institute of TechnologyCambridgeUSA

Personalised recommendations