Cell Conformation and Growth Control
Studies on the control of growth of mammalian cells have focused primarily on the role of diffusible factors, in the promotion of cell growth. However, a number of experimental results in the last several years suggest that there is another level at which cell growth may be controlled. These studies show that cell conformation plays a crucial role in growth control. The term “conformation” as used here refers both to cell shape and to the nature of the cell-substratum interaction. The experimental studies which will be described here show that cell conformation has a profound influence on (a) cell growth; (b) RNA and protein metabolism; and (c) gene expression. Furthermore, the acquisition of the fully transformed or neoplastic phenotype appears to involve the loss of the conformational-related control of these processes.
KeywordsLabel Index Cell Shape Confluent Culture Diploid Fibroblast Untransformed Cell
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- 6.Tucker, R. and Folkman, J. Unpublished observations.Google Scholar
- 10.Glowacki, J., Trepman, E. and Folkman, J. (1981). In preparation.Google Scholar
- 11.Azizkhan, J. and Klagsburn, M. (1981). In preparation.Google Scholar
- 12.Wittelsberger, A. and Penman, S. (1981). Cell, in press.Google Scholar
- 14.Foulds, L. (1975). Neoplastic Development, Vol. 2, ( Academic Press, New York ).Google Scholar
- 16.Barrett, J.C. (1980). Cane. Res. 40, 91–94.Google Scholar
- 20.Lenk, R. and Penman, S. (1979). Cell 16, 289, 301.Google Scholar
- 21.Cervera, M., Dreyfuss, G. and Penman, S. (1981). Cell, in press.Google Scholar
- 26.Schwartz, S.M. Selden, S.C. and Bowman, P. (1979). In Hormones and Cell Culture, eds. Sato, G.H. and Ross, R. Cold Spring Harbor Laboratory Press ), pp. 593–610.Google Scholar