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Cell Growth pp 575-585 | Cite as

Cell Conformation and Growth Control

  • Scott Wittelsberger
  • Judah Folkman
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 38)

Abstract

Studies on the control of growth of mammalian cells have focused primarily on the role of diffusible factors, in the promotion of cell growth. However, a number of experimental results in the last several years suggest that there is another level at which cell growth may be controlled. These studies show that cell conformation plays a crucial role in growth control. The term “conformation” as used here refers both to cell shape and to the nature of the cell-substratum interaction. The experimental studies which will be described here show that cell conformation has a profound influence on (a) cell growth; (b) RNA and protein metabolism; and (c) gene expression. Furthermore, the acquisition of the fully transformed or neoplastic phenotype appears to involve the loss of the conformational-related control of these processes.

Keywords

Label Index Cell Shape Confluent Culture Diploid Fibroblast Untransformed Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Scott Wittelsberger
    • 1
    • 2
    • 3
    • 4
  • Judah Folkman
    • 1
    • 2
    • 3
    • 4
  1. 1.Department of SurgeryChildren’s Hospital Medical CenterUSA
  2. 2.Department of AnatomyHarvard Medical SchoolBostonUSA
  3. 3.Department of SurgeryHarvard Medical SchoolBostonUSA
  4. 4.Department of BiologyMassachusetts Institute of TechnologyCambridgeUSA

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