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Cell Growth pp 557-573 | Cite as

Reverse Transformation of Chinese Hamster Cells by Cyclic AMP and Hormones

  • Abraham W. Hsie
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 38)

Summary

Treatment with cyclic AMP agents causes morphological conversion of spontaneous transformed epithelioid-like Chinese hamster ovary cells to a fibroblast-like shape. The morphological transformation is accompanied by the reversal of various transformed characteristics to the normal ones, such as the reorientation of the cytoplasmic microtubule-microfilament system through the action of cAMP-dependent protein kinase.

Keywords

Chinese Hamster Ovary Cell Protein Kinase Activity Cell Elongation Reverse Transformation Population Doubling Time 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Abraham W. Hsie
    • 1
  1. 1.Biology DivisionOak Ridge National LaboratoryOak RidgeUSA

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