Cell Growth pp 487-520 | Cite as

Higher Order Chromatin Structure, Proteins, c-AMP, Ions Modifications and Cell Cycle Progression: Experimental Results and Polyelectrolyte Theory

  • C. Nicolini
  • A. Belmont
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 38)


The traditional view on the cell cycle and the numerous biochemical, structural, morphological changes during the various subphases, particularly for what concerns the initiation of RNA synthesis, DNA replication and mitosis, have been well summarized in previous chapters of this book. The intent of this chapter is to furnish additional experimental evidences related to changes occurring at the level of higher order chromatin structure (1) c-AMP, histone — non-histone proteins, and ions, and to attempt a coherent synthesis of alternative mechanisms determining G1→S, G2→M, G0→G1 transitions, within the analytical framework of polyelectrolyte theory (2). All studies here reported utilized mammalian HeLa S3 cells, synchronized by selective mitotic detachment (3).


HeLa Cell Chromatin Structure Nuclear Morphometry Nuclear Border Picture Point 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • C. Nicolini
    • 1
    • 2
  • A. Belmont
    • 1
    • 2
  1. 1.Department of Biophysics - PhysiologyTemple UniversityUSA
  2. 2.National Research CouncilItaly

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