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Cell Growth pp 463-486 | Cite as

Minor Components of the Chromatin and Their Role in the Release of Template Restriction

  • F. A. Manzoli
  • S. Capitani
  • N. M. Maraldi
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 38)

Abstract

Many aspects of the expression of the genome informational content have been clarified by using cell-free systems. However, the nucleus is far from being a container of a collection of molecules; on the contrary, it must be considered as one of the most complex exemples of the close relationship existing between the structural arrangement of macromolecules and their metabolic expression. These correlations can be considered as a window open on the cell metabolism, so that different moments of the cell cycle and of the cell differentiation can be monitored by analyzing the morphological changes which occur inside the nucleus. In this respect the nuclear volume enlargement and the chromatin dispersion are targets of metabolic activation. On the other hand, the transitions which occur at the five levels of organization of the chromatin (1) are not the unique factors affecting the nuclear morphology, which depends also on two other structures, the nuclear envelope (NE) and the nuclear matrix.

Keywords

Chronic Lymphocytic Leukemia Polyaspartic Acid Chromatin Fraction Chaotropic Effect Template Restriction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • F. A. Manzoli
    • 1
    • 2
  • S. Capitani
    • 1
    • 2
  • N. M. Maraldi
    • 1
    • 2
  1. 1.Institutes of Human AnatomyUniversities of Bologna and FerraraItaly
  2. 2.Institute of Histology and General EmbryologyUniversity of AnconaItaly

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