The Cell Life Cycle and the G1 Period
The classical experiment of Howard and Pelc (1) showed that the reproductive cycle of plant root cells was divisible into four periods of time: G1, S, G2, and M. This organization of cell reproductive events has come to serve as a conceptual foundation for the study of cell reproduction in a wide variety of unicellular and multicellular organisms. It is generally accepted that the cell cycle is a sequence of events that is based in turn on a set of specific genes termed the cell cycle genes. Presumably, the sequential occurrence of these cell cycle events is established by causal relationships between successively functioning products of cell cycle genes, e.g. in the simplest sense the occurrence of one event triggers the next, and so on. Thus, the orderliness of the events by which a cell progresses from division to division resides in underlying causal relationships among these events based on the cell cycle genes.
KeywordsGrowth Cycle Cell Cycle Gene Chinese Hamster Cell Pyrimidine Nucleoside Mammalian Cell Cycle
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