Chromosome Aberrations and Mammalian Reproduction

  • Mitchell S. Golbus


Chromosome heteroploidy is responsible for a substantial segment of observed birth defects and reproductive inefficiency. Sterility, reduced fertility, embryonic or fetal death, stillbirths, and/or congenital malformation may result from an aberration in chromosome number. Sandier and Hecht (1973) argue that the maximum nonlethal excess of autosomal DNA in humans is 5–6% and that deletion of more than 2–3% of the haploid autosomal complement is incompatible with life.


Chromosome Abnormality Spontaneous Abortion Chromosome Aberration Syrian Hamster Preimplantation Embryo 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Mitchell S. Golbus
    • 1
  1. 1.Departments of Obstetrics, Gynecology, and Reproductive Sciences and of PediatricsUniversity of California Medical CenterSan FranciscoUSA

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