Studies on Drug Resistance Transposons in Haemophilus influenzae R Plasmids
The emergence of R plasmids in H. influenzae is of great clinical concern, since H. influenzae causes serious infections including meningitis, epiglottitis, pneumonia, and otitis media. Resistance to ampicillin (Ap), as well as to tetracycline (Tc) was shown to be plasmid linked (1, 2). The conjugative Haemophilus R plasmids that have been described are closely related to each other and have most of their base sequences in common independent of their geographical origins and their antibiotic resistance markers (3, 4). This paper examines whether these R factors arose as a result of the transposition of different resistance genes on to closely related indigenous H. influenzae plasmids or whether closely related R factors from the same incompatibility group with different resistance genes have now infected H. influenzae strains throughout the world.
KeywordsInverted Repeat Haemophilus Influenzae Multiple Integration Ampicillin Resistance Chloramphenicol Resistance
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