R Plasmids in Pathogenic Enterobacteriaceae from Calves

  • John F. Timoney


Pressure for selection of antibiotic resistant bacteria is greater in intensive calf raising than in any other livestock raising operation. The newborn calf is particularly vulnerable to enteric infections because it is often colostrum deprived, transported long distances without food, mixed with calves from other sources and therefore simultaneously stressed and exposed to a variety of pathogenic strains to which it may have no immunity. The crowded nature of the intensive rearing environment further facilitates spread of infection and favors accelerated feco-oral transfer of enteric pathogens in the group.


Enteric Pathogen Phage Type Antibiotic Resistant Bacterium Antibiotic Usage Ampicillin Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    J. F. Timoney. The epidemiology and genetics of Salmonella typhimurium isolated from diseased animals in New York. J. Infec. Dis. 137: 67 (1978).CrossRefGoogle Scholar
  2. 2.
    C. E. Cherubin, J. F. Timoney, M. F. Sierra, P. Ma, J. Marr, and S. Shin. A sudden decline in ampicillin resistance in Salmon-ella typhimurium. J. Am. Med. Assoc. 243: 439 (1980).CrossRefGoogle Scholar
  3. 3.
    D. P. Aden, N. D. Reed, N. R. Underdahl, and C. A. Mebus. Transferable drug resistance among Enterobacteriaceae isolated from cases of neonatal diarrhea in calves and piglets. Appl. Microbiol. 18: 961 (1969).PubMedGoogle Scholar
  4. 4.
    E. S. Anderson. The ecology of transferable drug resistance in the enterobacteria. Annual Review of Microbiology 22: 131 (1968).PubMedCrossRefGoogle Scholar
  5. 5.
    R. V. Threlfall, L. R. Ward, and B. Rowe. Epidemic spread of a chloramphenicol resistant strain of Salmonella typhimurium phage type 204 in bovine animals in Britain. Vet. Rec. 130: 438 (1978).CrossRefGoogle Scholar
  6. 6.
    J. F. Timoney, D. E. Taylor, S. Shin, and P. McDonough. pJT2: Unusual H1 plasmid in a highly virulent lactose positive and chloramphenicol-resistant Salmonella typhimurium strain from calves. Antimicrob. Agents Chemother. 18: 480 (1980).PubMedCrossRefGoogle Scholar
  7. 7.
    K. Howe and A. H. Linton. The distribution of 0-antigen types of Escherichia coli in normal calves, compared with man and their R plasmid carriage. J.Appl. Bact. 40: 317 (1976).CrossRefGoogle Scholar
  8. 8.
    D. E. Taylor and R. B. Grant. Inhibition of bacteriophage lambda, Tl, and T7 development by R plasmids of the H incompatibility group. Antimicrob. Agents Chemother. 10: 762 (1977).CrossRefGoogle Scholar
  9. 9.
    E. S. Anderson and L. S. Lewis. Characterization of a transfer factor associated with drug resistance in Salmonella typhimurium. Nature. 208: 843 (1965).PubMedCrossRefGoogle Scholar
  10. 10.
    J. H. Crosa, J. Olarte, L. S. Mata, C. K. Lattrop, and M. E. Penarenda. Characterization of an R plasmid associated with ampicillin resistance in Shigella dysenteriae type 1 strains isolated in epidemics. Antimicrob. Agents Chemother. 11: 553 (1977).PubMedCrossRefGoogle Scholar
  11. 11.
    D. E. Taylor and R. B. Grant. R plasmids of the S incompatibility group belong to the H2 incompatibility group. Antimicrob. Agents Chemother. 12: 431 (1977).CrossRefGoogle Scholar
  12. 12.
    H. W. Smith, Z. Parsell, and P. Green. Thermosensitive antibiotic resistance plasmids in enterobacteria. J. Gen. Microbiol. 109: 37 (1978).PubMedCrossRefGoogle Scholar
  13. 13.
    A. H. Linton, J. F. Timoney, and M. Hinton. The ecology of chloramphenicol resistance in Salmonella typhimurium and Escherichia coli in calves. J. Appl. Bact. In Press. (1981).Google Scholar
  14. 14.
    D. E. Taylor and J. G. Levine. Studies of temperature-sensitive transfer and maintenance of H Incompatibility group plasmids. J. Gen. Microbiol. 116: 475 (1980).PubMedGoogle Scholar
  15. 15.
    H. W. Smith and M. A. Linggood. Observations on the pathogenic properties of the K88, HCY and ENT plasmids of Escherichia coli with particular reference to porcine diarrhoea. J. Med. Microbiol. 4: 467 (1971).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • John F. Timoney
    • 1
  1. 1.Department of MicrobiologyN.Y. State College of Veterinary Medicine Cornell UniversityIthacaUSA

Personalised recommendations