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The Structure of Tn5

  • W. S. Reznikoff
  • S. J. Rothstein
  • R. A. Jorgensen
  • R. C. Johnson
  • J. C. P. Yin

Abstract

Tn5 is a transposable genetic element which encodes resistance to aminoglycoside antibiotics such as kanamycin and neomycin. This resistance results from the synthesis of the enzyme neomycin phosphotransferase type II (NPTII, also named aminoglycoside 3′-phos-photransferase-II) (Berg et al., 1978). Its structure is in general similar to other transposons with two inverted repeats 1534 bp long (Auerswald and Schaller, 1980) flanking a unique central region approximately 2700 bp long (Berg et al., 1975; Jorgensen et al., 1979).

Keywords

Inverted Repeat Aminoglycoside Antibiotic BglII Site Transposition Process Additional Amino Acid Residue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • W. S. Reznikoff
    • 1
  • S. J. Rothstein
    • 1
  • R. A. Jorgensen
    • 1
  • R. C. Johnson
    • 1
  • J. C. P. Yin
    • 1
  1. 1.Department of BiochemistryUniversity of WisconsinMadisonUSA

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