Trimethoprim-Resistant Bacteria in Hospital and in the Community: Spread of Plasmids and Transposons
Trimethoprim is a very effective synthetic antibacterial drug that was introduced for use in human and veterinary medicine about 10 years ago in Europe (7 years in the US). Until recently it has been used always in conjunction with a sulfonamide. Trimethoprim and sulfonamides act synergistically, at different points upon the folic acid cycle of bacteria and using both drugs together should prevent the emergence of resistant mutants1. Trimethoprim-sulfonamide preparations are effective against a wide range of bacteria and have been extensively used in treating urinary, respiratory and, to a lesser extent, gastrointestinal infections in hospitals and in the community.
KeywordsUrinary Tract Infection Haemophilus Influenzae Urinary Infection Neisseria Gonorrhoeae Dihydrofolate Reductase
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- 4.J. M. T. Hamilton-Miller, Mechanisms and distribution of bacterial resistance to diaminopyrimidines and sulfonamides, J. antimicrob. Chemother. 5:(suppl. B) 6l–T3 (1979).Google Scholar
- 6.R. W. Lacey, V. L. Lord, H. K. W. Gunasekera, P. J. Lieberman, and D. E. A. Luxtpn, Comparison of trimethoprim alone with trimethoprim-sulfamethoxazole in the treatment of respiratory and urinary infections with particular reference to selection of trimethoprim resistance, Lancet 1: 1270–1273 (1980).PubMedCrossRefGoogle Scholar
- 13.J. A. Shapiro, and P. Sporn, Transposon Tn402: a new trans-posable element determining trimethoprim resistance that inserts into bacteriophage lambda, J. Bact. 129: l632–1635 (1977).Google Scholar
- l4.A. W. Asscher, E. R. Verrier-Jones, K. Verrier-Jones, R. Mackenzie, and L. A. Williams, Bacteriologic follow-up of schoolgirls with untreated covert bacteruria, Kidney International l6: 92 (1979).Google Scholar
- 15.E. J. Stokes, and P. M. Waterworth, Antibiotic sensitivity tests by diffusion methods, Association of Clinical Pathologists Broadsheet, 55: 1–12, British Medical Association, London (1972).Google Scholar
- 19.J. L. Harkness, F. M. Anderson, and N. Datta, R factors in urinary tract infection, Kidney International 8: S130–S133 (1975).Google Scholar
- 27.M. E. Fling, and L. P. Elwell, Protein expression in Escherichia coli minicells containing recombinant plasmids specifying trimethoprim-resistant dihydrofolate reductase, J. Bact. l41: 779–785 (1980).Google Scholar