The Pathway of Plasmid Transformation in Pneumococcus

  • Walter R. Guild
  • Charles W. Saunders


Plasmids transform Streptococcus pneumoniae by a process involving low efficiency assembly of replicons from fragments of single strands that have entered the cell separately. Transformation of preexisting replicons is much more efficient. We have cloned the erm gene of pIP501 into pMV158, which so far as we know is the first example of cloning in a pneumococcus host-vector system.


Single Strand Transforming Activity Plasmid Transformation Multimeric Form Plasmid Replicon 
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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Walter R. Guild
    • 1
  • Charles W. Saunders
    • 1
  1. 1.Department of BiochemistryDuke UniversityDurhamUSA

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