Serum Resistance in E.coli

  • Kenneth N. Timmis
  • Paul A. Manning
  • Christine Echarti
  • Joan K. Timmis
  • Albrecht Moll


Pathogenic bacteria that cause generalized infections or meningitis invade the blood stream and are thereby distributed throughout the body. Blood, or serum, contains a number of nonspecific (complement, lysozyme, phagocytes, iron-binding proteins, etc.) and specific (antibodies, lymphocytes) agents that alone or in combination lyse, kill or prevent the growth of the majority of bacteria with which they make contact. Abilities to resist, evade or inactivate these host defences constitute major components of the virulence of invasive bacteria. At present little is known about these bacterial properties or their molecular interactions with host defences.


Outer Membrane Serum Resistance Outer Membrane Protein Mutant Plasmid Hybrid Plasmid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    G.K. Schoolnik, T.M. Buchanan, and K.K. Holmes, J. Clin. Invest. 58: 1163–1173 (1976).PubMedCrossRefGoogle Scholar
  2. 2.
    M.S. Simberkoff, I. Ricupero, and J.J. Rahal, Jr., J. Lab. Clin. Med. 87: 206–217 (1976).PubMedGoogle Scholar
  3. 3.
    B. Björksten and B. Kaijser, Infect. Immun. 22: 308–311 (1978).PubMedGoogle Scholar
  4. 4.
    G. Archer and F.R. Fekety, J. Infect. Dis. 134: 1–7 (1976).PubMedCrossRefGoogle Scholar
  5. 5.
    D.T. Durack and P.B. Beeson, Infect. Immun. 16: 213–217 (1977).PubMedGoogle Scholar
  6. 6.
    A.M. Reynard and M.E. Beck, Infect. Immun. 14: 848–850 (1976).PubMedGoogle Scholar
  7. 7.
    A. Fietta, E. Romero, and A.G. Siccardi, Infect. Immun. 18: 278–282 (1977).PubMedGoogle Scholar
  8. 8.
    P.W. Taylor and C. Hughes, Infect. Immun. 22: 10–17 (1978).PubMedGoogle Scholar
  9. 9.
    R.P. Silver and S.N. Cohen, J. Bacteriol. 110: 1082–1088 (1972).PubMedGoogle Scholar
  10. 10.
    K.N. Timmis, F. Cabello, and S.N. Cohen, Molec. Gen. Genet. 162: 121–137 (1978).PubMedCrossRefGoogle Scholar
  11. 11.
    M. Achtman, B. Kusecek, and K.N. Timmis, Molec. Gen. Genet. 163: 169–179 (1978).PubMedCrossRefGoogle Scholar
  12. 12.
    A. Moll, P.A. Manning, and K.N. Timmis, Infect. Immun. 28: 359–367 (1980).PubMedGoogle Scholar
  13. 13.
    P.A. Manning and M. Achtman, in_: “Bacterial Outer Membranes: Biogenesis and Functions”, M. Inouye, ed., Wiley, New York pp. 409–447 (1979).Google Scholar
  14. 14.
    A. Moll, F. Cabello, and K.N. Timmis, FEMS Lett. 6: 273–276 (1979).CrossRefGoogle Scholar
  15. 15.
    P.A. Manning, L. Beutin, and M. Achtman, J. Bacteriol. 142: 285–294 (1980).PubMedGoogle Scholar
  16. 16.
    D. Ferrazza and S.B. Levy, J. Bacteriol. 144: 149–158 (1980).PubMedGoogle Scholar
  17. 17.
    R.T. Ogata and R.P. Levine, J. Immunol. 125: 1494–1498 (1980).PubMedGoogle Scholar
  18. 18.
    P.A. Manning, C. Echarti, and K.N. Timmis, to be submitted.Google Scholar
  19. 19.
    J.B. Robbins, G.H. McCracken, E.C. Gotschlich, F. Orskov, I. Orskov, and L.A. Hanson, New Eng. J. Med. 290: 1216–1220 (1974).PubMedCrossRefGoogle Scholar
  20. 20.
    M. Glode, A. Sutton, R. Moxon, and J.B. Robbins, Infect. Immun. 16: 75–80 (1977).PubMedGoogle Scholar
  21. 21.
    F. Cabello in: “Plasmids of Medical, Environmental and Commercial Importance”, K.N. Timmis and A. Punier, eds., Elsevier/North Holland, Amsterdam, pp. 155–160 (1979).Google Scholar
  22. 22.
    R. Bortolussi, P. Ferrieri, B. Bjorksten, and P.G. Cline, Infect. Immun. 25: 293–298 (1979).PubMedGoogle Scholar
  23. 23.
    A.A. Glynn and C.J. Howard, Immunol. 18: 331–346 (1970).Google Scholar
  24. 24.
    W.R. McCabe, B. Kaijser, S. Oiling, M. Uwaydah, and L.A. Hanson, J. Infect. Dis. 138: 33–40 (1978).PubMedCrossRefGoogle Scholar
  25. 25.
    J. Pitt, Infect. Immun. 22: 219–224 (1978).PubMedGoogle Scholar
  26. 26.
    B. Hohn and N. Hinnen, in: “Genetic Engineeri1ng, Principles and Methods”, Vol 2, J.K. Setlow and A. Hollaender, eds., Plenum, New York, pp. 169–183 (1980).Google Scholar
  27. 27.
    P. Gemski, A.S. Cross, and J.C. Sadoff, FEMS Lett. 9: 193–197 (1980).CrossRefGoogle Scholar
  28. 28.
    M.E. Bayer, J. Gen. Microbiol. 53: 395–404 (1968).PubMedCrossRefGoogle Scholar
  29. 29.
    H.W. Smith, J. Gen. Microbiol. 83: 95–111 (1974).PubMedCrossRefGoogle Scholar
  30. 30.
    H.W. Smith and M.B. Huggins, J. Gen. Microbiol. 92: 335–350 (1976).PubMedCrossRefGoogle Scholar
  31. 31.
    M.M. Binns, D.L. Davies, and K.G. Hardy, Nature 279: 778–781 (1979).PubMedCrossRefGoogle Scholar
  32. 32.
    J.F. Hildebrandt, L.W. Mayer, S.P. Wang, and T.M. Buchanan, Infect. Immun. 20: 267–273 (1978).PubMedGoogle Scholar
  33. 33.
    J.B. Robbins, R. Schneerson, W.B. Egan, W. Vann, and D.T. Liu, in: “The Molecular Basis of Microbial Pathogenicity”, H. Smith, J.J. Skehel, and M.J. Turner, eds., Verlag Chemie, Weinheim, pp. 115–132 (1980).Google Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Kenneth N. Timmis
    • 1
  • Paul A. Manning
    • 1
  • Christine Echarti
    • 1
  • Joan K. Timmis
    • 1
  • Albrecht Moll
    • 1
  1. 1.Max-Planck-Institute for Molecular GeneticsBerlin-DahlemWest Germany

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