Bacterial Pathogenicity, an Overview
The majority of infectious diseases had begun to decline at the turn of the century with the understanding that potentially dangerous microbes could be transmitted by water, food and insects and by the application of sanitation and antisepsis. Since the birth of the modern antibiotic era some 45 years ago the incidence of bacterial disease has declined further and, despite the marvels of R plasmids we heard earlier today, most bacterial infections can be controlled, though usually not prevented, by chemotherapy. Some bacterial infections can be prevented by immunization although except for certain toxins, immunization is generally based on hit or miss whole organism vacccines. The fact is that if we understood more about how particular microorganisms caused infection it might be possible to devise rational means to prevent them.
KeywordsBacterial Pathogenicity Bacterial Toxin Epithelial Cell Surface Bordetella Pertussis Shigella Flexneri
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- 2.Center for Disease Control, Legionnaires Disease: Diagnosis and Management. Ann. Intern. Med. 88, 363 (1978).Google Scholar
- 3.K.N. Timmis and A. Puhler (ed), Plasmids of Medical, Environmental and Commercial Importance. Elsevier/North Holland Biomedical Press, Amsterdam (1979).Google Scholar
- 5.C.A. Mims, The Pathogenesis of Infectious Disease, Academic Press, London (1976).Google Scholar
- 6.P.D. Hoeprich (ed) Infectious Diseses, Harper and Row, Hagerstown, MD (1977).Google Scholar
- 7.G.P. Youmans, P.Y. Paterson and H.M. Sommers, The Biologic and Clinical Basis of Infectious Diseases, W.B. Saunders, Philadelphia, PA (1979).Google Scholar
- 8.G.L. Mandell, R.G. Douglas, Jr., and J.E. Bennett, Principles and Practice of Infectious Diseases, John Wiley and Sons, New York, N.Y. (1979).Google Scholar
- 11.G.W. Jones, The attachment of bacteria to the surfaces of animal cells, in J.L. Reissig (ed) Receptors and Recognition, Sec. B, Vol. 3, Microbial Interactions, John Wiley and Sons, New York, N.Y. (1978).Google Scholar
- 12.J. Mestecky, J.R. McGhee, S.S. Crago, S. Jackson, M. Kilian, H. Kiyono, J.LI Babb and S.M. Michalek. J. Reticuloend. Soc. 28, 450 (1980).Google Scholar
- 13.S.L. Moseley and S. Falkow, Nucleotide sequence homology between the heat-labile enterotoxin gene of Escherichia coli and Vibrio cholerae deoxyribonucleic acid, J. Bacterol. 144, 444 (1980).Google Scholar