Functional Aspects of Endometrial Hyperplasia and Carcinoma

  • Rodrigue Mortel
  • Paul Robel
  • Etienne Emile Baulieu


Hyperplasia and adenocarcinoma of the endometrium occur primarily in women subjected to long-standing, unopposed estrogenic stimulation (MacMahon, 1974; Smith et al., 1975; Gusberg, 1976). In addition, obesity, diabetes, hypertension and late menopause are encountered in a high percentage of these patients, suggesting that endometrial carcinoma may be an endocrinopathy (Kelley, 1973). Consequently, in the past several years, gynecologists, endocrinologists, and biochemists have developed a considerable interest in the study of hyperplastic and malignant endometria. Studies have been designed to establish the hormonal aspects of neoplastic endometrium and its functional relationship to normal endometrium.


Progesterone Receptor Endometrial Cancer Endometrial Carcinoma Hypogastric Artery Endometrial Hyperplasia 


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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Rodrigue Mortel
    • 1
  • Paul Robel
    • 1
  • Etienne Emile Baulieu
    • 1
  1. 1.Unité de Recherches sur le Métabolisme Moléculaire et la Physio-Pathologie des StéroidesL’Institut National de la Sante et de la Recherche, Médicale, (U33 INSERM) and ER 125 CNRSBicetreFrance

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