Pathogenesis of Pulmonary Fibrosis due to Asbestos and Silica
Inhalation of silica or asbestos for a sufficient time and at a sufficient dose can lead to irreversible damage of the blood/gas barrier and pleura. As well as these particles being fibrogenic, asbestos has been shown to be associated with’increase in bronchial carcinomas and mesotheliomas (Becklake, 1976). The effects of these particles on lung is dependent on a number of variable factors — puriety, dose, physical and chemical composition and host factors which alter normal pulmonary defense mechanism: for example, existing acute or chronic inflammation, cigarette smoke, immunological status and lung anatomical variations which may cause alterations in the site of particle retention between individuals.
KeywordsPulmonary Fibrosis Mononuclear Phagocyte Asbestos Exposure Diffusion Chamber Progressive Fibrosis
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