Drug Induced Hypersensitivity and Paraquat

  • Paul Smith
Part of the Ettore Majorana International Science Series book series (EMISS, volume 6)


To date there are well over 40 drugs or therapeutic agents which are known to produce pathological changes in the lungs of humans (Rosenow, 1972). In addition there are several other agents which will induce changes in the lungs of animals for which a human association has not been demonstrated. In this paper I shall confine myself to five of these, namely busulphan, bleomycin, chlorphentermine, iprindole and paraquat.


Pulmonary Fibrosis Alveolar Epithelium Lamellar Body Alveolar Wall Pulmonary Alveolar Proteinosis 
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  1. Adamson, I.Y.R. and Bowden, D.H., 1974, The pathogenesis of bleomycin-induced pulmonary fibrosis in mice, Am. J. Pathol., 77:185.PubMedGoogle Scholar
  2. Aso, Y., Yoneda, K., and Kikkawa, Y., 1976, Morphologic and biochemical study of pulmonary changes induced by bleomycin in mice, Lab Invest., 35: 558.PubMedGoogle Scholar
  3. Autor, A.P., 1974, Reduction of paraquat toxicity by superoxide dismutase, Life Sci., 14:1309.PubMedCrossRefGoogle Scholar
  4. Bus, J.S., Aust, S.D., and Gibson, J.E., 1977, Lipid peroxidation as a proposed mechanism for paraquat toxicity, in: “Biochemical Mechanisms of Paraquat Toxicity,” A.P. Autor, ed., Academic Press, London.Google Scholar
  5. Cavalli, R.D., and Fletcher, K., 1977, An effective treatment for paraquat poisoning, in: “Biochemical Mechanisms of Paraquat Toxicity,” A.P. Autor, ed, Academic Press, London.Google Scholar
  6. Copland, G.M., Kolin, A., and Shulman, H.S., 1974, Fatal pulmonary intra-alveolar fibrosis after paraquat ingestion, New Eng. J. Med., 291:290.PubMedCrossRefGoogle Scholar
  7. Dearden, L.C., Fairshter, R. D., McRae, D.M., Smith, W.R., Glauser, F.L., and Wilson, A.F., 1978, Pulmonary ultrastructure of the late aspects of human paraquat poisoning, Amer. J. Path., 93:667.PubMedGoogle Scholar
  8. Drenckhahn, D., Kleine, L., and Lullmann-Rauch, R., 1976, Lysosomal alterations in cultured macrophages exposed to anorexigenic and psychotropic drugs, Lab. Invest., 35: 116.PubMedGoogle Scholar
  9. Fleischman, R.W., Baker, J.R., Thompson, G.R., Schaeppi, U.M., Illievski, V.R., Cooney, D.A., and Davies, R.D., 1971, Bleomycin induced interstitial pneumonia in dogs, Thorax, 26: 675.PubMedCrossRefGoogle Scholar
  10. Gage, J.C., 1968, Toxicity of paraquat and diquat aerosols generated by a size-selective cyclone effect of particle size distribution, Brit. J. Industr. Med., 25: 304.PubMedGoogle Scholar
  11. Heard, B.E., and Cooke, R.A., 1968, Busulphan lung, Thorax, 23:187.PubMedCrossRefGoogle Scholar
  12. Heath, D., Smith, P., and Hasleton, P.S., 1973, The effects of chlor-phentermine on the rat lung. Thorax, 28:551.PubMedCrossRefGoogle Scholar
  13. Jones, A.W., and Reeve, N.L., 1978, Ultrastructural study of bleomycin-induced pulmonary changes in mice, J. Path., 124: 227.PubMedCrossRefGoogle Scholar
  14. Kelly, D.F., Morgan, D.G., Darke, P.G.G., Gibbs, C, Pearson, H., and Weaver, B.M.Q., 1978, Pathology of acute respiratory distress in the dog associated with paraquat poisoning, J. Comp. Path., 88:275.PubMedCrossRefGoogle Scholar
  15. Littler, W.A., Kay, J.M., Hasleton, P.S., and Heath, D., 1969, Busulphan lung, Thorax, 24:639.PubMedCrossRefGoogle Scholar
  16. Lullmann, H., Lullmann-Rauch, R., and Wassermann, O., 1975, Drug-induced phospholipidoses, C.R.C. Crit. Rev. Toxicol., 4:185.Google Scholar
  17. Luna, M.A., Bedrossian, C.W.M., Lichtiger, B., and Salem, P.A., 1972, Interstitial pneumonitis associated with bleomycin therapy, Am, J. Clin. Path., 58:501.Google Scholar
  18. Rebello, G., and Mason, J.K., 1978, Pulmonary histological appearances in fatal paraquat poisoning, Histopathology, 2: 53.PubMedCrossRefGoogle Scholar
  19. Rhodes, M.L., Zavala, D.C., and Brown, D., 1976, Hypoxic protection in paraquat poisoning, Lab. Invest., 35: 496.PubMedGoogle Scholar
  20. Rose, M.S., Lock, E.A., Smith, L.L., and Wyatt, I., 1976, Paraquat accumulation: Tissue and species specif icily, Biochem. Pharmacol., 25:419.PubMedCrossRefGoogle Scholar
  21. Rose, M.S., Smith, L.L., and Wyatt, I., 1974, Evidence for energy-dependent accumulation of paraquat into rat lung, Nature (Lond.), 252:314.CrossRefGoogle Scholar
  22. Rosenow, E.C., 1972, The spectrum of drug induced pulmonary disease. A review, Ann. Intern. Med., 77:977.PubMedGoogle Scholar
  23. Smith, P., and Heath, D., 1974a, The ultrastructure and time sequence of the early stages of paraquat lung in rats, J. Path., 114: 117.Google Scholar
  24. Smith, P., and Heath, D., 1974b, Paraquat lung: A reappraisal, Thorax, 29:643.PubMedCrossRefGoogle Scholar
  25. Smith, P., and Heath, D., 1976, Paraquat, C.R.C. Crit. Rev. Toxicol., 4:411.Google Scholar
  26. Smith, P., Heath, D., and Hasleton, P.S., 1973, Electron microscopy of chlorphentermine lung, Thorax, 28:559.PubMedCrossRefGoogle Scholar
  27. Smith, P., Heath, D., and Hasleton, P.S., 1974a, Effects of prolonged administration of chlorphentermine on the rat lung, Path. Europ., 9: 273.Google Scholar
  28. Smith, P., Heath, D., and Kay, J.M., 1974b, The pathogenesis and structure of paraquat-induced pulmonary fibrosis in rats, J. Path., 114:57.PubMedCrossRefGoogle Scholar
  29. Sykes, B.I., Purchase, I.F.H., and Smith, L.L., 1977, Pulmonary ultra-structure after oral and intravenous dosage of paraquat to rats, J. Path., 121:233.PubMedCrossRefGoogle Scholar
  30. Toner, P.G., Vetters, J.M., Spilg, W.G.S., and Harland, W.A., 1970, Fine structure of the lung lesion in a case of paraquat poisoning, J. Path., 102:182.PubMedCrossRefGoogle Scholar
  31. Vijeyaratnam, G.S., and Corrin, B., 1971, Experimental paraquat poisoning: A histological and electron-optical study of the changes in the lung, J. Path., 103:123.PubMedCrossRefGoogle Scholar
  32. Vijeyaratnam, G.S., and Corrin, B., 1972, Pulmonary histiocytosis simulating desquamative interstitial pneumonia in rats receiving oral iprindole, J. Path., 108:105.PubMedCrossRefGoogle Scholar
  33. Vijeyaratnam, G.S., and Corrin, B., 1973, Pulmonary alveolar proteinosis developing from desquamative interstitial pneumonia in long term toxicity studies of ipr indole in the rat. Virch. Arch. Path. Anat 351:1.Google Scholar
  34. Vijeyaratnam, G.S., and Corrin, B., 1974, Fine structural alterations in the lungs of iprindoIe-treated rats, J, Path., 114: 233.CrossRefGoogle Scholar
  35. Weibel, E.R., Kistler, G.S., and Töndury, G., 1966, A stereologic electron microscopic study of “tubular myelin figures” in alveolar fluids of rat lungs, Z. Zellforsch., 69:418.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Paul Smith
    • 1
  1. 1.Department of PathologyUniversity of LiverpoolEngland

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