Interaction Between Mineral Fibres and Pulmonary Cells

  • Jean Bignon
  • Marie-Claude Jaurand
  • Patrick Sebastien
Part of the Ettore Majorana International Science Series book series (EMISS, volume 6)

Abstract

It is now well documented from human and animal data that asbestos exposure is associated with the development of two kinds of diseases: 1/ Fibrosis, not only of lung parenchyma (asbestosis) but also of pleura (pleural plaques); 2/ Cancer, mostly bronchogenic carcinoma and pleural or peritoneal mesothelioma, and also laryngeal cancer, gastro-intestinal tumors and perhaps cancer of other site (1, 2). Initially, such diseases were observed only in asbestos workers, some of them such as mesothelioma or lung cancer after a long latency period of 20 to 40 years (3). At present, with the increasing consumption and accumulation of asbestos dusts in our environment, the asbestos-related diseases increase steadily in incidence and are also observed in association with moderate para-occupational (domestic) or environmental exposures (3, 4). More recently, other fibres, either natural (zeolite) or man made fibres (glass fibres) were shown to have the same potential hazards! (5)

Keywords

Dust Silicate Zeolite Turkey Smoke 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    IARC Monographs on the evaluation of carcinogenic risk of chemicals to man. Asbestos, vol 14, International Agency for Research on Cancer, Lyon (1977).Google Scholar
  2. 2.
    Health hazards of asbestos exposure. I.J. Selikoff and E.C. Hammond eds., Ann. N.Y. Acad. Sci., 330 (1979).Google Scholar
  3. 3.
    M.R. Becklake, Asbestos related diseases of the lung and other organs: their epidemiological and implications for clinical practice. Amer. Rev. Resp. Dis., 114: 187 (1976).PubMedGoogle Scholar
  4. 4.
    Public Health risks of exposure to asbestos. Commission of the European Communities. Pergamon Press, Luxembourg, (1977).Google Scholar
  5. 5.
    J. Bignon, Introduction. Les contaminants fibreux. Rev. Fr. Mal. Resp., 7: 675 (1979).Google Scholar
  6. 6.
    M.C. Jaurand, J. Bignon, L. Magne, A. Renier and J. Lafuma, Interaction des fibres avec les globules rouges et les macrophages alveolaires in vitro. Rev. Fr. Mal. Resp., 7: 717 (1979).Google Scholar
  7. 7.
    J. Bignon, M.C. Jaurand and L. Magne, Effets cytotoxiques des asbestes en relation avec leurs proprietes physico-chimiques. Etude in vitro sur globules rouges, macrophages alveolaires et cellules mesotheliales. Contrat CCE 264 77 6 ENV F (1979).Google Scholar
  8. 8.
    C.C. Gravatt, P.D. Lafleur and K.F. J. Heinrich, Workshop on asbestos: definitions and measurement methods. NBS Special Publication, 506 (1978).Google Scholar
  9. 9.
    J. Goni, J. Bignon and G. Bonnaud, Les asbestes. Leurs menaces sur l’environnement urbain et sur la sante. Revue Nuisances et Environnement, Janvier-Fevrier-Mars (1974).Google Scholar
  10. 10.
    M. Attivinili and Y.I. Baris, Malignant mesotheliomas in a small village in the Anatolian region of Turkey: an epidemiologic study. JNCI, 63: 17 (1979).Google Scholar
  11. 11.
    J. Bignon, P. Sebastien, A. Gaudichet and M.C. Jaurand, Biological effects of attapulgite. Biological effects of mineral fibres. IARC Conference, Lyon, 25—27 Septembre (1979) (in the press).Google Scholar
  12. 12.
    Task Group on lung dynamics. Deposition and retention models for internal dosimetry of the human respiratory tract. Health Phys., 12: 173 (1966).Google Scholar
  13. 13.
    V. Timbrell, The inhalation of fibres. “Pneumoconiosis” Proceedings of the International Conference, Johannesburg. H.A. Shapiro ed. Oxford University Press (1970).Google Scholar
  14. 14.
    R.L. Harris and V. Timbrell, The influence of fibre shape in lung deposition. Mathematical estimates. “Inhaled Particles”, IV, W.H. Walton ed. Pergamon Press Oxford (1977), p. 75.Google Scholar
  15. 15.
    P. Sebastien, A. Fondimare, J. Bignon, G. Monchaux, J. Desbordes and G. Bonnaud, Topographic distribution of asbestos fibres in human lung in relation to occupational and non-occupational exposure. “Inhaled Particles”, IV, W.H. Walton ed., Pergamon Press Oxford (1977), p. 435.Google Scholar
  16. 16.
    A. Morgan, J.C. Evans and A. Holmes, Deposition and clearance of inhaled fibrous minerals in the rat. Studies using radioactive tracer techniques. “Inhaled Particles”, IV, W.H. Walton ed., Pergamon Press Oxford (1977), p. 259.Google Scholar
  17. 17.
    J. Goni, J.H. Thomassin, M.C. Jaurand and J.C. Touray, Photoelectron spectroscopy analysis of asbestos dissolution in acidic media of biological interest. “Origin and distribution of the elements”. L.H. Ahrens ed. Pergamon Press, Oxford & New York (1979), p. 807.Google Scholar
  18. 18.
    J.M.G. Davis, Further observations on the ultrastructure and chemistry of the formation of asbestos bodies. Exp. Mol. Pathol., 13: 346 (1970).PubMedCrossRefGoogle Scholar
  19. 19.
    J. Bignon, Effets biologiques des polluants particulaires inorganiques. XVII Congres National de la Tuberculose et des maladies respiratoires, Clermont Ferrand, Masson ed. Paris (1974), p. 207.Google Scholar
  20. 20.
    M.C. Jaurand, J. Bignon, P. Sebastien and J. Goni, Leaching of chrysotile asbestos in human lungs. Environ. Res., 14: 245 (1977).PubMedCrossRefGoogle Scholar
  21. 21.
    J. Bignon, P. Sebastien and M. Bientz, Review of some factors relevant to the assessment of exposure to asbestos dusts. “The Use of biological specimens for the assessment of human exposure to environmental pollutants”. A. Berlin, A.H. Wolff & Y. Hasegawa eds. Martinus Nijhoff Publishers, The Hague, Boston, London (1979).Google Scholar
  22. 22.
    J.C. Wagner, G. Berry, J.W. Skidmore and V. Timbrell, The effects of the inhalation of asbestos in rats. Br. J. Cancer, 29: 252 (1974).PubMedCrossRefGoogle Scholar
  23. 23.
    J. Bignon, P. Sebastien and A. Gaudichet, Measurement of asbestos retention in human respiratory system related to health effects. “Workshop on asbestos: definitions and measurement methods”. C. C. Gravatt, P.D. Lafleur & K.F.J. Heinrich eds., NBS Special Publication (1978).Google Scholar
  24. 24.
    E. Taskinen, K. Ahlman and M. Wiikeri, A current hypothesis of the lymphatic transport of inspired dust to the parietal pleura. Chest, 64: 193 (1973).PubMedCrossRefGoogle Scholar
  25. 25.
    K. Kanazawa, F.J.C. Roe and T. Yamamoto, Milky spots (taches laiteuses) as structures which trap asbestos in raeso-thelial layers and their significance in the pathogenesis of mesothelial neoplasia. Int. J. Cancer, 23: 858 (1979).PubMedCrossRefGoogle Scholar
  26. 26.
    M.C. Jaurand, J. Bignon, A. Gaudichet, L. Magne and A. Oblin, Biological effects of chrysotile after SO2 sorption. II Effects on alveolar macrophages and red blood cells. Environ. Res., 17: 216 (1978).PubMedCrossRefGoogle Scholar
  27. 27.
    C. Schoenberger, G. Hunningrake, J. Gadek and R.G. Crystal, Role of alveolar macrophages in asbestosis: modulation of neutrophil migration to the lung following asbestos exposure. Amer. Rev. Resp. Dis., 121: 257a (1980).Google Scholar
  28. 28.
    L. Di Menza, F. Ruff, J. Bignon, G. Bonnaud and G. Brouet, Obstruction des voies aériennes périphériques au cours de l’exposition professionnelle à l’amiante. Ann. Anat. Pathol., 21: 261 (1976).Google Scholar
  29. 29.
    D.R. Gracey, M.B. Divertie and A.L. Brown, The blood air barrier in pulmonary asbestosis study of a case by electron microscopy. Chest, 63: 46 (1973).PubMedCrossRefGoogle Scholar
  30. 30.
    J.M.G. Davis, S.T. Beckett, R.E. Bolton, P. Collings and A.P. Middleton, Mass and number of fibres in the pathogenesis of asbestos-related lung disease in rats. Br. J. Cancer, 37: 673 (1978).PubMedCrossRefGoogle Scholar
  31. 31.
    G.W. Wright and M. Kuschner, The influence of varying lengths of glass and asbestos fibres on tissue response in Guinea Pigs. “Inhaled Particles”, IV, W.H. Walton ed., Pergamon Press Oxford (1977).Google Scholar
  32. 32.
    A.C. Allison, I.A. Clark and P. Davies, Cellular interactions in fibrogenesis. Ann. Rheum., 36: 8 (1977).CrossRefGoogle Scholar
  33. 33.
    A.G. Heppleston and J.A. Styles, Activity of a macrophage factor in collagen formation by silica. Nature, 214: 521 (1967).PubMedCrossRefGoogle Scholar
  34. 34.
    I. Berenblum, The mechanisms of carcinogenesis. A study of the significance of cocarcinogenic action and related phenomena. Cancer Res., 1: 807 (1941).Google Scholar
  35. 35.
    M. Chamberlain and E.M. Tarmy, Asbestos and glass fibres in bacterial mutation tests. Mutation Res., 43: 159 (1977).PubMedCrossRefGoogle Scholar
  36. 36.
    H. Kaplan, A. Renier, M.C. Jaurand and J. Bignon, Sister chromatid exchanges in mesothelial cells cultured with chrysotile fibres. “The in vitro effects of mineral dusts”. Cardiff 3-7 Septembre 1979 (in the press).Google Scholar
  37. 37.
    E.C. Hammond, I.J. Selikoff and H. Seidman, Asbestos exposure cigarette smoking and death rates. Ann. N.Y. Acad. Sci., 330: 473 (1979).PubMedCrossRefGoogle Scholar
  38. 38.
    J. Lafuma, A. Hirsch, G. Monchaux, M. Morin, J.L. Poncy, R. Masse and J. Bignon, Mesothelia induced by intrapleural injection of different types of fibres in the rat. Synergestic effect of other carcinogens. “Biological effects of mineral fibres”, IARC Conference Lyon, 25-27 Septembre 1979 (in the press).Google Scholar
  39. 39.
    B.S. Oppenheimer, E.T. Oppenheimer, I. Danishefsky, A.P. Stout and F.R. Eirich, Further studies of polymers as carcinogenic agents in animals. Cancer Res., 15: 333 (1955).PubMedGoogle Scholar
  40. 40.
    I.M. Goldstein, Effects of phorbol esters on polymorphonuclear leukocyte functions in vitro carcinogenesis. “Mechanism of tumor. Promotion and cocarcinogenesis” vol 2, T.J. Slaga, A. Sivak and R.K. Boutwell eds, Raven Press, New York (1978).Google Scholar
  41. 41.
    M.F. Stanton, M. Layard, A. Tegeris, E. Miller, M. May and E. Kent, Carcinogenicity of fibrous glass: pleural response in the rat in relation to fiber dimension. J. Natl. Cancer, Inst., 58: 587 (1977).Google Scholar
  42. 42.
    M.F. Stanton and M. Layard, The carcinogenicity of fibrous minerals. “Workshop on Asbestos: defintitions and measurement methods”. C.C. Gravatt, P.D. Lafleur & K.F.J. Heinrich eds., NBS Special Publication, (1978).Google Scholar
  43. 43.
    W.G. Light and E.T. Wei, Surface charge and asbestos toxicity. Nature, 265: 537 (1977).PubMedCrossRefGoogle Scholar
  44. 44.
    M.C. Jaurand, J. Bignon, L. Magne, A. Renier and J. Lafuma, Interaction des fibres avec les globules rouges et les macrophages alveolaires in vitro. Rev. Fr. Mal. Resp., 7: 717 (1979).Google Scholar
  45. 45.
    A. Morgan, P. Davies, J.C. Wagner, G. Berry and A. Holmes, The biological effects of magnesium leached chrysotile asbestos. Br. J. Exp. Pathol., 58: 465 (1977).PubMedGoogle Scholar
  46. 46.
    G. Brouet, J. Bignon, G. Bonnaud and J. Goni, Incidence sur la santé de la pollution atmosphérique par l’asbeste ou autres particules fibreuses. Rev. Tuberc. Pneumol., 35: 461 (1971).Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Jean Bignon
    • 1
  • Marie-Claude Jaurand
    • 1
  • Patrick Sebastien
    • 1
  1. 1.Service de PneumologieERA CNRS 845, INSERM U 139Creteil cedexFrance

Personalised recommendations