Interaction Between Mineral Fibres and Pulmonary Cells

  • Jean Bignon
  • Marie-Claude Jaurand
  • Patrick Sebastien
Part of the Ettore Majorana International Science Series book series (EMISS, volume 6)


It is now well documented from human and animal data that asbestos exposure is associated with the development of two kinds of diseases: 1/ Fibrosis, not only of lung parenchyma (asbestosis) but also of pleura (pleural plaques); 2/ Cancer, mostly bronchogenic carcinoma and pleural or peritoneal mesothelioma, and also laryngeal cancer, gastro-intestinal tumors and perhaps cancer of other site (1, 2). Initially, such diseases were observed only in asbestos workers, some of them such as mesothelioma or lung cancer after a long latency period of 20 to 40 years (3). At present, with the increasing consumption and accumulation of asbestos dusts in our environment, the asbestos-related diseases increase steadily in incidence and are also observed in association with moderate para-occupational (domestic) or environmental exposures (3, 4). More recently, other fibres, either natural (zeolite) or man made fibres (glass fibres) were shown to have the same potential hazards! (5)


Alveolar Space Asbestos Exposure Bronchogenic Carcinoma Parietal Pleura Chrysotile Asbestos 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Jean Bignon
    • 1
  • Marie-Claude Jaurand
    • 1
  • Patrick Sebastien
    • 1
  1. 1.Service de PneumologieERA CNRS 845, INSERM U 139Creteil cedexFrance

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