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A Presynaptic Voltage Clamp Study in the Squid Stellate Ganglion

  • R. Llinás
  • K. Walton

Abstract

The importance of extracellular calcium in synaptic transmission was first recognized by Locke (29) in 1894. Working with a frog nerve-muscle preparation, he observed that if calcium was removed from the bathing medium, stimulation of the nerve did not elicit muscle contraction, although the muscle did contract when stimulated directly. Addition of calcium to the bathing medium restored the effectiveness of nerve stimulation. More recently, further work with the neuromuscular junction has elucidated the role of calcium in synaptic transmission (cf. 9). This work established the effective location (calcium must be present at the site of the junction itself) (7,10,11) and the timing (calcium must be present immediately before or during nerve stimulation) (13) of the calcium action.

Keywords

Synaptic Transmission Calcium Current Transmitter Release Voltage Clamp Presynaptic Terminal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • R. Llinás
    • 1
  • K. Walton
    • 1
  1. 1.Department of Physiology and BiophysicsNew York University Medical CenterNew YorkUSA

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