Regulatory Mechanisms of REM Sleep in the Cat
Today it is universally accepted that mammals and primates present at least two basic stages of sleep. The state of sleep is first characterized electroencephalographically by the appearance of 14–18 Hz cortical spindles, which are subsequently replaced by 2–4Hz slow waves. At the same time, high-voltage (500–800μV) sharp waves are recorded from the hippocampus, while the electromyogram (EMG) decreases slightly. Usually after some 30–40 minutes the electrophysiological signs of slow wave sleep (SWS) are replaced by low-voltage fast cortical EEG activity, regular hippocampal theta rhythm (5–6 Hz), isoelectric EMG, burst of rapid eye movements (REM), and pontogeniculooccipital (PGO) waves. PGO waves appear in SWS approximately one minute before all REM sleep periods. These PGO spikes exhibit a fairly constant daily rate of about 14,000 in the cat (18), may exist in man (30) and are made up of simple Type I and complex Type II spikes (24).
KeywordsSlow Wave Sleep Protein Synthesis Inhibitor Lateral Geniculate Body Midbrain Reticular Formation Multiple Unit Activity
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