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Calcium Current Modulation as a Mechanism in the Synaptic Plasticity Underlying Habituation and Sensitization in Aplysia

  • Mark Klein

Abstract

Habituation and sensitization are two simple forms of learning which occur widely throughout the animal kingdom (26). Habituation is the decline in reflex responsiveness which occurs when a stimulus is presented repeatedly, while sensitization is the increase in responsiveness which results from the transient presentation of a novel stimulus. Although this definition does not exclude the possibility that what happens in sensitization might simply be the opposite of what happens during habituation, earlier work has shown that sensitization is in actuality a distinct process, superimposable on habituation and having its own discernible properties and time course (3,9). In this report, I present experiments which address the question of the cellular mechanisms of both habituation and sensitization, and which confirm, at the level of the biophysics of single neurons, the distinctiveness of sensitization as a process in its own right, independent of habituation. To be more specific, the results of these experiments imply that both habituation and sensitization result from changes in transmitter release consequent to modulation of the influx of calcium ions into the terminals of the presynaptic element in the reflex pathway. They also imply, however, that habituation results from a decrease in calcium influx due to the properties of the calcium channels themselves, whereas sensitization occurs because of an increased calcium influx which results from a change in the properties of a different set of ionic channels in the presynaptic membrane.

Keywords

Sensory Neuron Synaptic Plasticity Action Potential Duration Outward Current Calcium Current 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Mark Klein
    • 1
  1. 1.Department of Physiology and Division of Neurobiology and BehaviorCollege of Physicians & Surgeons Columbia UniversityNew YorkUSA

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