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Effect of Nerve Growth Factor on Microtubules: Evidence for a Protective Action against Depolymerization Induced by Calcium Ions or Cold Treatment

  • P. Calissano
  • D. Mercanti
  • G. Monaco
  • L. Castellani

Abstract

Although the powerful and specific promoting activity of nerve growth factor (NGF) was first reported more than 25 years ago (1), still little is known about its molecular mechanisms and physiological action. This is frequently the case in the field of hormones and growth factors, whose phenomenological aspects (spectrum of actions, number and type of target cells, etc.) become known even decades before the understanding of their mechanism of action. This gap is mainly due to lack of a precise knowledge of how several eukariotic cells respond to a given external stimulus. The discovery of second messengers is a remarkable exception to this rule, but it would be unwise, in our opinion, to consider them as transducers or amplifiers for all hormones and growth factors.

Keywords

Nerve Growth Factor Neurite Growth Cold Treatment Axonal Growth Vinca Alkaloid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • P. Calissano
    • 1
  • D. Mercanti
    • 1
  • G. Monaco
    • 1
  • L. Castellani
    • 1
  1. 1.Laboratorio di Biologia Cellulare, C.N.R., Via Romagnosi. 18A, and Instituto di Anatomia ComparataUniversita di RomaRomaItaly

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