Effect of Nerve Growth Factor on Microtubules: Evidence for a Protective Action against Depolymerization Induced by Calcium Ions or Cold Treatment
Although the powerful and specific promoting activity of nerve growth factor (NGF) was first reported more than 25 years ago (1), still little is known about its molecular mechanisms and physiological action. This is frequently the case in the field of hormones and growth factors, whose phenomenological aspects (spectrum of actions, number and type of target cells, etc.) become known even decades before the understanding of their mechanism of action. This gap is mainly due to lack of a precise knowledge of how several eukariotic cells respond to a given external stimulus. The discovery of second messengers is a remarkable exception to this rule, but it would be unwise, in our opinion, to consider them as transducers or amplifiers for all hormones and growth factors.
KeywordsNerve Growth Factor Neurite Growth Cold Treatment Axonal Growth Vinca Alkaloid
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