Calcium, Calmodulin, and Synaptic Function: Modulation of Neurotransmitter Release, Nerve Terminal Protein Phosphorylation, and Synaptic Vesicle Morphology by Calcium and Calmodulin

  • Robert J. DeLorenzo


An understanding of the molecular mechanism underlying calcium-dependent neurotransmitter release would greatly enhance our knowledge of synaptic transmission and the action of specific neuropharmacologic agents, and possibly provide new insights into human disease processes involving synaptic modulation. Although calcium’s role in neurotransmitter release from the presynaptic nerve terminal has been of great interest, little is known about the molecular mechanisms of Ca2+ in stimulating neurotransmitter release or its other physiological functions in the nerve terminal. Ca2+ was shown to stimulate the endogenous phosphorylation of whole brain (8–10,15) and synaptosomal proteins (10,16) and it was suggested from these results that the effects of calcium on protein phosphorylation might play a role in mediating some of the effects of this ion on neuronal tissue.


Synaptic Vesicle Protein Phosphorylation Neurotransmitter Release Scorpion Venom Synaptic Vesicle Protein 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Robert J. DeLorenzo
    • 1
  1. 1.Department of NeurologyYale University School of MedicineNew HavenUSA

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