Fine Structure of Aging Skeletal Muscle
Diminution of motor performance and decrease in muscle weight relative to body weight are prominent features in old age, but the mechanisms involved in these changes are not known. The histological alterations in skeletal muscles that might account for these deficits have been examined in both human and animal studies, and several reviews have been published recently (e.g., Gutmann, 1977; McComas, 1977; Kaldor and DiBattista, 1978). In general, it has been found that there is a reduction in both the number and the diameter of muscle fibers (Tucek and Gutmann, 1973; Adams and Victor, 1977) as well as an increased variation of fiber sizes, with some fibers becoming hypertrophic perhaps to compensate for the loss and atrophy of others (Rowe, 1969; Jennekens et al., 1971).
KeywordsMotor Unit Spinal Muscular Atrophy Quadriceps Muscle Muscular Atrophy Autophagic Vacuole
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