Ultrastructure of the Aging Kidney
Man’s aging organs play essential roles in dictating longevity, or lack thereof, of his physical and mental processes. Not the least of these organs are the kidneys, which receive much attention in pathologic states in young and middle life, but little notice in senescence. Gross studies indicate that overall kidney size, weight, amount of cortex, and number of glomeruli decrease with age, although this is variable, while light microscopic examinations reveal numerous alterations including nephron obsolescence, vascular sclerosis, interstitial fibrosis, basement membrane thickening, and various types of histologic degeneration (Dunnill and Halley, 1973; Darmady et al., 1973; McLachlan, 1978; Mclachlan et al., 1977). These changes of aging are associated with a decline of glomerular filtration rate and various types of tubular dysfunction (Friedman et al., 1972; Korenchevsky, 1961; Epstein, 1979; Papper, 1973). Although gross, anatomic, light microscopic, and functional studies in the aging kidney may be few, they are plentiful in relationship to ultrastructural studies of the kidney in aging man.
KeywordsGlomerular Basement Membrane Mesangial Matrix Short Arrow Lamina Densa Tubular Basement Membrane
Unable to display preview. Download preview PDF.
- Addis, T., Marmorston, J., Goodman, H. C., Sellers, A. L., and Smith, M., 1950, Effect of adrenalectomy on spontaneous and induced proteinuria in the rat, Froc. Soc. Exp. Biol. Med. 74:43.Google Scholar
- Andres, G. A., Morgan, C., Hsu, K. C., Rifkind, R. A., and Seegal, B. C., 1962, Electron microscopic studies of experimental nephritis with ferritin-conjugated antibody: The basement membranes and cisternae of visceral epithelial cells in nephritic rat glomeruli, J. Exp. Med. 115:929.PubMedCrossRefGoogle Scholar
- Couser, W. G., and Stilmant, M. M., 1975b, The immunopathology of the aging rat kidney, J. Gerontol. 31:13.Google Scholar
- Korenchevsky, V., 1961, Kidneys and aging in: Physiological and Pathological Ageing (G. Bourne, ed.), p. 432, Hafner, New York.Google Scholar
- Romen, W., 1975, The pathogenesis of the glomerulosclerosis of aging—Light and electron microscopic studies, Ver. Dtsch. Ges. Pathol. 59:370.Google Scholar
- Saxton, J. A., and Kimball, G. C., 1941, Relation of nephrosis and other diseases of albino rats to age and to modification of diet, Arch. Pathol. 32:951.Google Scholar
- Webber, W. A., and Blackbourn, J., 1970, The permeability of the immature glomerulus to large molecules, Lab. Invest. 231:1.Google Scholar