Connective Tissue Disorder (Systemic Lupus Erythematosus)
Systemic lupus erythematosus (SLE) is a disseminated disease of multiform character and unknown cause. Current evidence shows that immunologic mechanisms of tissue injury are important in its pathogenesis. Roles for genetic predisposition and viral infection are also hypothesized (Mannik and Gilliland, 1977). The serum of patients with SLE contains many antibodies, collectively called antinuclear antibodies (ANA). The complexes formed by the combining of ANA with specific antigens appear to contribute to the inflammatory process and to formation of fibrinoid deposits that are commonly found in blood vessels, among collagen fibers, and on serosal surfaces. The widespread nature of these changes accounts for the multitude of clinical manifestations. Demonstration of the presence of ANA is essential for the diagnosis.
KeywordsSystemic Lupus Erythematosus Systemic Lupus Erythematosus Patient Psychiatric Symptom Optic Neuritis Connective Tissue Disorder
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