Connective Tissue Disorder (Systemic Lupus Erythematosus)

  • James W. Jefferson
  • John R. Marshall
Part of the Critical Issues in Psychiatry book series (CIPS)


Systemic lupus erythematosus (SLE) is a disseminated disease of multiform character and unknown cause. Current evidence shows that immunologic mechanisms of tissue injury are important in its pathogenesis. Roles for genetic predisposition and viral infection are also hypothesized (Mannik and Gilliland, 1977). The serum of patients with SLE contains many antibodies, collectively called antinuclear antibodies (ANA). The complexes formed by the combining of ANA with specific antigens appear to contribute to the inflammatory process and to formation of fibrinoid deposits that are commonly found in blood vessels, among collagen fibers, and on serosal surfaces. The widespread nature of these changes accounts for the multitude of clinical manifestations. Demonstration of the presence of ANA is essential for the diagnosis.


Systemic Lupus Erythematosus Systemic Lupus Erythematosus Patient Psychiatric Symptom Optic Neuritis Connective Tissue Disorder 
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  1. Andrew WF, Jr: Psychiatric illness associated with systemic lupus erythematosus. South Med J 68: 1207–1210, 1975.PubMedCrossRefGoogle Scholar
  2. Bennahum DA, Messner RP, Shoop JD: Brain scan findings in central nervous system involvement by lupus erythematosus. Ann Intern Med 81: 763–765, 1974.PubMedGoogle Scholar
  3. Clark EC, Bailey AA: Neurologic and psychiatric signs associated with systemic lupus erythematosus. JAMA 160: 455–457, 1956.CrossRefGoogle Scholar
  4. Dubois ED, Tuffanelli DL: Clinical manifestation of systemic lupus erythematosus. JAMA 190: 112–119, 1964.CrossRefGoogle Scholar
  5. Estes D, Christian CL: The natural history of systemic lupus erythematosus by prospective analysis. Medicine 50: 85–95, 1971.PubMedCrossRefGoogle Scholar
  6. Feinglass EJ, Arnett FC, Dorsch CA, et al: Neuropsychiatric manifestations of systemic lupus erythematosus: Diagnosis, clinical spectrum and relationship to other features of the disease. Medicine 55: 323–339, 1976.PubMedCrossRefGoogle Scholar
  7. Ganz VF, Gurland BJ, Demming E, et al: The study of the psychiatric symptoms of systemic lupus erythematosus: A biometric study. Psychosom Med 34: 207–219, 1972.PubMedGoogle Scholar
  8. Gibson T, Myers AR: Nervous system involvement in systemic lupus erythematosus. Ann Rheum Dis 35: 398–406, 1976.Google Scholar
  9. Gurland BJ, Ganz VF, Fleiss JL, et al: The study of the psychiatric symptoms of systemic lupus erythematosus. Psychosom Med 34: 199–206, 1972.PubMedGoogle Scholar
  10. Guze SB: The occurrence of psychiatric illness and systemic lupus erythematosus. Am J Psychiatry 123: 1562–1570, 1967.PubMedGoogle Scholar
  11. Johnson RT, Richardson EP: The neurologic manifestations of systemic lupus erythematosus. Medicine 47: 337–369, 1968.PubMedCrossRefGoogle Scholar
  12. Kronfol Z, Schlesser M, Gsuang MT: Catatonia and systemic lupus erythematosus. Dis New Syst 38: 729–731, 1977.Google Scholar
  13. Lief VF, Silverman T: Psychosis associated with lupus erythematosus disseminatus. Arch Gen Psychiat 3: 608–611, 1960.PubMedCrossRefGoogle Scholar
  14. MacNeil A, Grennan DMO, Ward D, et al: Psychiatric problems in systemic lupus erythematosus. Br J Psychiatry 128: 442–445, 1976.CrossRefGoogle Scholar
  15. Macrae D, O’Reilly S: On some neuro-oto-ophthalmological manifestations of systemic lupus erythematosus and peri arteritis nodosa. Eye Ear Nose Throat 36: 721–724, 1957.Google Scholar
  16. Mannik M, Gilliland BC: Systemic lupus erythematosus, in Thorn GW, Adams RD, Braunwald E (eds): Harrison’s Principles of Internal Medicine, ed 8. New York, McGraw–Hill, 1977, pp 426–430.Google Scholar
  17. O’Connor JF: Psychoses associated with systemic lupus erythematosus. Ann Intern Med 51: 526–536, 1959.PubMedGoogle Scholar
  18. Sergent JS, Lockshin MD, Klempner NS, et al: Central nervous system disease in systemic lupus erythematosus: Therapy and prognosis. Am J Med 58: 644–655, 1975.PubMedCrossRefGoogle Scholar
  19. Shearn M, Pirofsky B: Disseminated lupus erythematosus: Analysis of thirty-four cases. Arch Intern Med 9: 790–796, 1953.Google Scholar
  20. Siekert RG, Clark EC: Neurologic signs and symptoms as early manifestations of systemic lupus erythematosus. Neurology 5: 84–88, 1955.PubMedCrossRefGoogle Scholar
  21. Small P, Mas MF, Kohler PF, Harback RJ: Central nervous system involvement in SLE. Arthritis Rheum 20: 869–878, 1977.PubMedCrossRefGoogle Scholar
  22. Stern M, Robbins ES: Psychoses in systemic lupus erythematosus. Arch Gen Psychiatry 3: 205–210, 1960.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1981

Authors and Affiliations

  • James W. Jefferson
    • 1
  • John R. Marshall
    • 1
  1. 1.University of Wisconsin Medical SchoolMadisonUSA

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