Advertisement

The Chemistry of Ia Antigens

  • Loran T. Clement
  • Ethan M. Shevach

Abstract

The I region of the major histocompatibility complex (MHC) contains genes which determine or regulate the ability of an animal to respond immunologically to an antigenic challenge (McDevitt and Benacerraf, 1969; Benacerraf and Mc Devitt, 1972). Owing to the potential significance of the genetic control of the immune response by these Ir genes, an intensive effort has been made to identify the gene products encoded for by the I region and to characterize the mechanism by which Ir-gene products influence or mediate immune responsiveness. In the course of these studies, it was demonstrated that lymphocytes express a cell surface molecule which bears antigenic determinants encoded for by genes in the I region (David et al., 1973; Gotze et al., 1973; Haupfeld et al., 1973; Sachs and Cone, l973;Hämmerling et al., 1974), and these molecules have now been termed I-region-associated, or Ia, antigens.

Keywords

Major Histocompatibility Complex Antigenic Determinant Subunit Structure Antigen Subunit Noncovalent Force 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

Ia

I-region-associated

HPLC

high-pressure liquid chromatography

MHC

major histocompatibility complex

MLR

mixed lymphocyte reaction

NGPS

normal guinea pig serum

SaCI

Staphylococcus aureus, Cowan I strain

SDS-PAGE

sodium dodecyl sulfate-polyacrylamide gel electrophoresis

TNBS

trinitrobenzene sulfonic acid

2-D PAGE

two-dimensional polyacrylamide gel electrophoresis

2-ME

2-mercaptoethanol

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abbas, A. K., Dorf, M. E., Karnovsky, M. J. and Unanue, E. R., 1976, J. Immunol 116:371.PubMedGoogle Scholar
  2. Albrechtsen, D., 1977, Scand. J. Immunol 6:907.PubMedCrossRefGoogle Scholar
  3. Armerding, D., Sachs, D. H., and Katz, D. H., 1974, J. Exp. Med. 140:1717.PubMedCrossRefGoogle Scholar
  4. Barnstable, C. J., Jones, E. A., Bodmer, W. F., Bodmer, J. G., Arce-Gomez, B., Snary, D., and Crumpton, M. J., 1976, Cold Spring Harbor Symp. Quant. Biol 41:443.CrossRefGoogle Scholar
  5. Basten, A., Miller, J. F. A. P., and Abraham, R., 1975, J. Exp. Med. 141:547.PubMedCrossRefGoogle Scholar
  6. Benacerraf, B., and Germain, R. N., 1978, Immunol Rev. 38:70.PubMedCrossRefGoogle Scholar
  7. Benacerraf, B., and McDevitt, H. O., 1972, Science 175:273.PubMedCrossRefGoogle Scholar
  8. Billing, R., Rafizadeh, B., Drew, I., Hartman, G., Gale, R., and Terasaki, P., 1976a, J. Exp. Med. 141:547.Google Scholar
  9. Billing, R. J., Safani, M., and Peterson, P., 1976b, J. Immunol 117:1589.PubMedGoogle Scholar
  10. Callahan, G. N., Ferrone, S., Poulik, M. D., and Reisfeld, R. A., 1976, J. Immunol. 117: 1351.PubMedGoogle Scholar
  11. Cecka, J. M., McMillan, M., Murphy, D. B., Silver, J., McDevitt, H. O., and Hood, L., 1978, in: Ir Genes and Ia Antigens (H. O. McDevitt, ed.), p. 275, Academic Press, New York.Google Scholar
  12. Clement, L. T., and Shevach, E. M., 1979, Mol. Immunol 16:67.PubMedCrossRefGoogle Scholar
  13. Clement, L. T., Kask, A. M., and Shevach, E. M., 1918, Jmmunochemistry 15:393.CrossRefGoogle Scholar
  14. Clement, L. T., Hu, C., Shevach, E. M., and Green, I., 1980, Blood 55:304.PubMedGoogle Scholar
  15. Chne, M. J., and Bilhng, R., 1977, J. Exp. Med. 146:1143.CrossRefGoogle Scholar
  16. Cook, R. G., Vitetta, E. S., Capra, J. D., and Uhr, J. W., 1977, Immunogenetics 5:437.CrossRefGoogle Scholar
  17. Cook, R. G., Uhr, J. W., Capra, J. D., and Vitetta, E. S., 1978, J. Immunol. 121:2205.PubMedGoogle Scholar
  18. Cook, R. G., Vitetta, E. S., Uhr, J. W., and Capra, J. D., 1979a, Mol Immunol 16:29.PubMedCrossRefGoogle Scholar
  19. Cook, R. G., Vitetta, E. S., Uhr, J. W., and Capra, J. D., 1979b, J. Exp. Med. 149:981.PubMedCrossRefGoogle Scholar
  20. Cresswell, P., 1977, Eur. J. Immunol 7:636.PubMedCrossRefGoogle Scholar
  21. Cullen, S. E., and Schwartz, B. D., 1976, J. Immunol 117:136.PubMedGoogle Scholar
  22. Cullen, S. E., David, C. S., Shreffler, D. C., and Nathenson, S. G., 1974, Proc. Natl. Acad. Sci. U.S.A. 71:648.PubMedCrossRefGoogle Scholar
  23. Cullen, S. E., Freed, J. H., Atkinson, P. H., and Nathenson ,S. G., 1975, Transplant. Proc. 7:237.Google Scholar
  24. Cullen, S. E., Freed, J. H., and Nathenson, S. G., 1976, Transplant. Rev. 30:236.PubMedGoogle Scholar
  25. Cullen, S. E., Kindle, C. S., and Littman, D. R., 1979, J. Immunol. 122:855.PubMedGoogle Scholar
  26. David, C. S., and Cullen, S. E., 1978, J. Immunol 120:1659.PubMedGoogle Scholar
  27. David, C. S., Shreffler, D. C., and Frehnger, J. A., 1973, Proc. Natl. Acad. Sci. U.S.A. 70: 2509.PubMedCrossRefGoogle Scholar
  28. David, C. S., Meo, T., McCormick, J., and Shreffler ,D. C., 1976, J. Exp. Med. 143:218.PubMedCrossRefGoogle Scholar
  29. Delovitch ,T. L., and Falk, J. A., 1979, Immunogenetics 8:405.CrossRefGoogle Scholar
  30. Delovitch, T. L., and McDevitt ,H. O. ,1975, Immunogenetics 2:39.CrossRefGoogle Scholar
  31. Delovitch, T. L., and McDevitt, H. O., 1977, J. Exp. Med. 146:1017.Google Scholar
  32. Delovitch, T. L., Press, J. L., and McDevitt, H. O., 1978, J. Immunol. 120:818.PubMedGoogle Scholar
  33. Dickler, H. B., and Sachs, D. H., 1974, J. Exp. Med. 140:779.PubMedCrossRefGoogle Scholar
  34. Emerson, S. G., and Cone, R. E., 1979, J. Immunol. 122:892.PubMedGoogle Scholar
  35. Erb, P., Feldmann, M., and Hogg, N., 1976, Eur. J. Immunol. 6:365.PubMedCrossRefGoogle Scholar
  36. Evans, R. L., Faldetta, T. J., Humphreys, R. E., Pratt, D. M., Yunis, E. J., and Schlossman, S. F., 1978, J. Exp. Med. 148:1440.PubMedCrossRefGoogle Scholar
  37. Fathman, C. G., Cone, J. L., Sharrow, S. O., Tyrer, H., and Sachs, D. H., 1975, J. Immunol. 115:584.PubMedGoogle Scholar
  38. Ferrone, S., Pellegrino, M. A., and Reisfeld, R. A., 1977, J. Immunol. 118:1036.PubMedGoogle Scholar
  39. Forman, J., Vitetta, E. S., Hart, D. A., and Klein, J., 1977, J. Immunol. 118:797.PubMedGoogle Scholar
  40. Forsum, U., Klareskog, L., and Peterson, P. A., 1979, Scand. J. Immunol. 9:343.PubMedCrossRefGoogle Scholar
  41. Freed, J. H., and Nathenson, S. G., 1977, J. Immunol. 119:477.PubMedGoogle Scholar
  42. Freed, J. H., David, C. S., Shreffler, D. C., and Nathenson, S. G., 1978, J. Immunol. 121:91.PubMedGoogle Scholar
  43. Frelinger, J. A., Neiderhuber, J. E., David, C. S., and Shreffler, D. C., 1974, J. Exp. Med. 140:1273.PubMedCrossRefGoogle Scholar
  44. Fu, S. M., Chiorazzi, N., Wang, C. Y., Montarezi, G., Kunkel, H. G., Ko, H. S., and Gottlieb, A. B., 1978, J. Exp. Med. 148:1093.CrossRefGoogle Scholar
  45. Fuks, A., Kaufman, J. F., Orr, H. T., Parham, P., Robb, R. R., Terhorst, C., and Strominger, J. L., 1977, Transplant. Proc. 9:1685.PubMedGoogle Scholar
  46. Geib, R., Poulik, M. D., Vitetta, E. S., Kearney, J. F., and Klein, J., 1976, J. Immunol. 117: 1532.PubMedGoogle Scholar
  47. Gotze, D., Reisfeld, R. A., and Klein, J., 1973, J. Exp. Med. 138:1003.PubMedCrossRefGoogle Scholar
  48. Greaves, M. F., Verbi, W., Festenstein, H., Papasteriadis, C., Jaraquemada, D., and Hayward, A., 1979, Eur. J. Immunol. 9:356.PubMedCrossRefGoogle Scholar
  49. Greene, M. I., Pierres, A., Dorf, M. E., and Benacerraf, B., 1977, J. Exp. Med. 146:293.PubMedCrossRefGoogle Scholar
  50. Halper, J., Fu, S. M., Wang, C. Y., Winchester, R., and Kunkel, H. G., 1978, J. Immunol. 120:1480.PubMedGoogle Scholar
  51. Hämmerling, G. J., 1976, Transplant. Rev. 30:64.PubMedGoogle Scholar
  52. Hämmerling, G. J., Deak, B. D., Mauve, G., HämmerUng, U., and McDevitt, H. O., 1974, Immunogenetics 1:68.CrossRefGoogle Scholar
  53. Hämmerling, U., Chin, A. F., and Abbott, J., 1976, Proc. Natl. Acad. Sci. U.S.A. 73:2008.PubMedCrossRefGoogle Scholar
  54. Hauptfeld, V., Klein, D., and Klein, J., 1973, Science 181:167.PubMedCrossRefGoogle Scholar
  55. Hayman, M. J., and Crumpton, M. J., 1972, Biochem. Biophys. Res. Commun. 47:923.PubMedCrossRefGoogle Scholar
  56. Helenius, A., and Simons, K., 1915, Biochim. Biophys. Acta 415:29.Google Scholar
  57. Hess, M., 1976, Transplant. Rev. 30:40.PubMedGoogle Scholar
  58. Honig, R., Billing, R., Matsuyama, M., and Terasaki, P. I., 1976, J. Immunol. 117:1300.PubMedGoogle Scholar
  59. Howie, S., Parish, C. R., David, C. S., McKenzie, I. F. C., Maurer, P. H., and Fledman, M., 1979, Eur. J. Immunol. 9:501.PubMedCrossRefGoogle Scholar
  60. Humphreys, R. E., McCune, J. M. ,Chess, L., Herrmann, H. C., Malenka, D. J., Mann, D. L., Parham, P., Schlossman, S. F., and Strominger, J. L., 1976, J. Exp. Med. 144:98.PubMedCrossRefGoogle Scholar
  61. Jackson, D. C., Parish, C. R., and McKenzie, I. F. C., 1977, Immunogenetics 4:267.CrossRefGoogle Scholar
  62. Jones, P. P., 1977, J. Exp. Med. 146:1261.PubMedCrossRefGoogle Scholar
  63. Jones, P. P., Murphy, D. B., and McDevitt, H. O., 1978a, J. Exp. Med. 148:925.PubMedCrossRefGoogle Scholar
  64. Jones, P. P., Murphy, D. B., and McDevitt, H. O., 1978b, in: Ir Genes and Ia Antigens (H. O. McDevitt, ed.), p. 203, Academic Press, New York.Google Scholar
  65. Jones, P. P., Murphy, D. B., Hewgill, D., and McDevitt, H. O., 1979, Mol. Immunol. 16:51.PubMedCrossRefGoogle Scholar
  66. Katz, D. H., Graves, M., Dorf, M. E., Dimuzio, H., and Benacerraf, B., 1975, J. Exp. Med. 141:263.PubMedCrossRefGoogle Scholar
  67. Kaufman, J., Shackelford, D., Ploegu, H., Englehard, V., and Strominger, J., 1979, Fed. Proc. 38:1280.Google Scholar
  68. Kessler, S. W., 1975, J. Immunol 115:1617.PubMedGoogle Scholar
  69. Klareskog, L., Sandberg-Tragardh, L., Rask, L., Lindblom, J. B., Curman, B., and Peterson, P. A., 1977a, Nature (London) 265:248.CrossRefGoogle Scholar
  70. Klareskog, L. ,Tjernlund, U. M., Forsum, U., and Peterson, P. A., 1977b, Nature (London) 268:248.CrossRefGoogle Scholar
  71. Klareskog, L. ,Rask, L. ,Fohlman, J., and Peterson, P. A., 1978, Nature (London) 275:762.CrossRefGoogle Scholar
  72. Klareskog, L., Tragardh, L., Rask, L., and Peterson, P. A., 1919, Biochemistry 18:1481.CrossRefGoogle Scholar
  73. Kontianien, S., and Feldmann, M., 1976, Eur. J. Immunol 6:296.CrossRefGoogle Scholar
  74. Koyama, K., Nakamuro, K., Tanigaki, N., and Pressman, D., 1977, Immunology 33:217.PubMedGoogle Scholar
  75. Laemmli, U. K., 1970, Nature (London) 277:680.CrossRefGoogle Scholar
  76. Lunney, J. K., and Sachs, D. H., 1979, J. Immunol 122:623.PubMedGoogle Scholar
  77. Mann, D. L., Abelson, L., Harris, S., and Amos, B. D., 1975, J. Exp. Med. 142:84.PubMedCrossRefGoogle Scholar
  78. McDevitt, H. O., and Benacerraf, B., 1969, Adv. Immunol 11:31.PubMedCrossRefGoogle Scholar
  79. McDougal, J. S., Cort, S. P., and Gordon, D. S., 1977, J. Immunol 119:1983.Google Scholar
  80. McKenzie, I. F. C., Clarke, A., and Parish, C. R., 1977, J. Exp. 145:1039.CrossRefGoogle Scholar
  81. McMilllan, M., Cecka, J. M., Murphy, D. B., McDevitt. H. O., and Hood, L., 1977, Proc. Natl. Acad. Sci. U.S.A. 74:5135.CrossRefGoogle Scholar
  82. McMillan, M., Cecka, J. M., Hood, L., Murphy, D. B., and McDevitt, H. O., 1979, Nature (London) 277:663.CrossRefGoogle Scholar
  83. Meo, T., David, C. S., Rijnbeek, A. M. ,Nabholz, M. ,Miggiano, V. C. ,and Shreffler, D. C., 1975, Transplant. Proc. 7:127.Google Scholar
  84. Murphy, D. B., Herzenberg, L. A., Okumura, K., Herzenberg, L. A., and McDevitt, H. O., 1976, J. Exp. Med. 144:699.PubMedCrossRefGoogle Scholar
  85. Nagy, Z. ,Elliot, B. E., Nabholz, M., Kramer, P. H., and Pernis, B., 1976, J. Exp. Med. 143: 648.PubMedCrossRefGoogle Scholar
  86. Nishikawa, Y., Yamamoto, Y., Onodera, K., Tamura, G., and Mitsui, H. ,1979, Biochem. Biophys. Res. Commun. 87:1235.PubMedCrossRefGoogle Scholar
  87. O’Farrell, P. H., 1975, J. Biol Chem. 250:4007.PubMedGoogle Scholar
  88. O’Farrell, P. Z. ,Goodman, H. M., and O’Farrell, P. H., 1977, Cell 12:1133.PubMedCrossRefGoogle Scholar
  89. Parish, C. R., Chilcott, A. B., and McKenzie, I. F. C., 1976a, Immunogenetics 3:113.CrossRefGoogle Scholar
  90. Parish, C. R., Chilcott, A. B., and McKenzie, I. F. C., 1976b, Immunogenetics 3:129.CrossRefGoogle Scholar
  91. Parish, C. R., Chilcott, A. B., and McKenzie, I. F. C., 1976c, Immunogenetics 3:455.CrossRefGoogle Scholar
  92. Parish, C. R., Higgins, T. J., and McKenzie, I. F. C., 1978, Immunogenetics 6:343.CrossRefGoogle Scholar
  93. Parr, E. L., and McKenzie, I. F. C., 1979, Immunogenetics 8:499.CrossRefGoogle Scholar
  94. Rich, S. S., David, C. S. ,and Rich, R. R., 1979, J. Exp. Med. 149:114.PubMedCrossRefGoogle Scholar
  95. Rosenthal, A. S., and Shevach, E. M., 1973, J. Exp. Med. 138:1194.PubMedCrossRefGoogle Scholar
  96. Rouse, R. V., van Ewijk, W., Jones, P. P., and Weissman, I. L., 1979, J. Immunol. 122:2508.PubMedGoogle Scholar
  97. Rowden, G., Lewis, M. G., and Sullivan, A. K., 1977, Nature (London) 268:247.CrossRefGoogle Scholar
  98. Sachs, D. H., and Cone, J. L., 1973, J. Exp. Med. 138:1289.PubMedCrossRefGoogle Scholar
  99. Sachs, D. H., Humphrey, G. W., and Lunney, J. K., 1977, J. Exp. Med. 146:381.PubMedCrossRefGoogle Scholar
  100. Schirrmacher, V., Halloran, P., and David, C. S., 1975, J. Exp. Med. 141:1201.PubMedCrossRefGoogle Scholar
  101. Schlossman, S. F., Chess, L., Humphreys, R. E., and Strominger, J. L., 1916, Proc. Natl. Acad. Sci. U.S.A. 73:1288.CrossRefGoogle Scholar
  102. Schwartz, B. D., and Cullen, S. E., 1978, Springer Semin. Immunopathol 1:85.CrossRefGoogle Scholar
  103. Schwartz, B. D., Kask, A. M., Paul, W. E., and Shevach, E. M., 1976a, J. Exp. Med. 143:541.PubMedCrossRefGoogle Scholar
  104. Schwartz, B. D., Paul, W. E., and Shevach, E. M., 1976b, Transplant. Rev. 30:174PubMedGoogle Scholar
  105. Schwartz, B. D., Kask, A. M., Paul, W. E., Geczy, A. F., and Shevach, E. M., 1977, J. Exp. Med. 146:547.PubMedCrossRefGoogle Scholar
  106. Schwartz, B. D., Vitetta, E. S., and Cullen, S. E., 1978, J. Immunol. 120:671.PubMedGoogle Scholar
  107. Schwartz, R. H., Dickler, H. B., Sachs, D. H., and Schwartz, B. D., 1976, Scand. J. Immunol. 5:731.PubMedCrossRefGoogle Scholar
  108. Shevach, E. M., 1978, Springer Semin. Immunopathol. 1:207.CrossRefGoogle Scholar
  109. Shevach, E. M., Paul, W. E., and Green, I., 1972, J. Exp. Med. 136:1207.PubMedCrossRefGoogle Scholar
  110. Shevach, E. M., Rosenstreich, D. L., and Green, I., 1973, Transplantation 16:126.PubMedCrossRefGoogle Scholar
  111. Shinohara, N., Lunney, J. K., and Sachs, D. H., 1978, J. Immunol 121:637.PubMedGoogle Scholar
  112. Shreffler, D. C., David, C. S., Cullen, S. E., Frelinger, J. A., and Neiderhuber, J. E., 1977, Cold Spring Harbor Symp. Quant. Biol 41:477.PubMedCrossRefGoogle Scholar
  113. Silver, J., and Ferrone, S., 1979, Nature (London) 279:437.CrossRefGoogle Scholar
  114. Silver, J., and Russell, W. A., 1979a, Nature (London) 279:437.CrossRefGoogle Scholar
  115. Silver, J., and Russell, W. A., 1979b, Immunogenetics 8:339.CrossRefGoogle Scholar
  116. Silver, J., Russell, W. A., Reis, B. L., and Frelinger, J. A., 1977, Proc. Natl. Acad. Sci. U.S.A.74:5131.PubMedCrossRefGoogle Scholar
  117. Silver, J., Walker, L. E., Reisfeld, R. A., Pellegrino, M. A., and Ferrone, S., 1979, Mol. Im munol. 16:37.CrossRefGoogle Scholar
  118. Snary, D., Barnstable, C. J., Bodmer, W. F., Goodfellow, P. N., and Crumpton, M. J., 1977, Scand. J. Immunol. 6:439.PubMedCrossRefGoogle Scholar
  119. Solheim, B. G., Thorsby, E., and Moller, E., 1976, J. Exp. Med. 143:1568.PubMedCrossRefGoogle Scholar
  120. Springer, T. A., Kaufman, J. F., Siddoway, L. A., Mann, D. L., and Strominger, J. L., 1977a, J.Biol Chem. 252:6201.PubMedGoogle Scholar
  121. Springer, T. A., Kaufman, J. F., Terhorst, C., and Strominger, J. L., 1977b, Nature (London)268:213.CrossRefGoogle Scholar
  122. Stingl, G., Katz, S. I., Clement, L., Green, I., and Shevach, E. M., 1978a, J. Immunol. 121: 2005.PubMedGoogle Scholar
  123. Stingl, G., Katz, S. I., Shevach, E. M., Wolff-Schreiner, E., and Green, I., 1978b, J. Immunol. 120:570.PubMedGoogle Scholar
  124. Tada, T., Taniguchi, M., and David, C. S., 1976, J. Exp. Med. 144:713.PubMedCrossRefGoogle Scholar
  125. Tada, T., Takcmori, T., Okumura, K., Noinaka, M., and Tokushisa, T., 1978, J. Exp. Med. 147:446.PubMedCrossRefGoogle Scholar
  126. Tamaki, K., Stingl, G., Gullino, M., Sachs, D. H., and Katz, S. I., 1979, J. Immunol. 123: 784.PubMedGoogle Scholar
  127. Taussig, M. J., Munro, A. J., Campbell, R., David, C. S., and Staines, N. A., 1975, J. Exp. Med. 142:694.PubMedCrossRefGoogle Scholar
  128. Theze, J., Waltenbaugh, C., Dorf, M. E., and Benacerraf, B., 1977, J. Exp. Med. 146:287.PubMedCrossRefGoogle Scholar
  129. Thomas, D. W., Yamashita, U., and Shevach, E. M., 1977, Immunol. Rev. 35:97.CrossRefGoogle Scholar
  130. Tosi, R., Tanigaki, N., Gentis, D., Ferrara, G. B., and Pressman, D., 1978, J. Exp. Med. 148: 1592.PubMedCrossRefGoogle Scholar
  131. Uhr, J. W., Capra, J. D., Vitetta, E. S., and Cook, R. G., 1979, Science 206:292.PubMedCrossRefGoogle Scholar
  132. Unanue, E. R., Dorf, M. E., David, C. S., and Benacerraf, B., 1974, Proc. Natl. Acad. Sci. U.S.A. 71:5014.PubMedCrossRefGoogle Scholar
  133. Vitetta, E. S., and Capra, J. D., 1978, Adv. Immunol. 26:148.Google Scholar
  134. Vitetta, E. S., Klein, J., and Uhr, J. W., 1974, Immunogenetics 1:82.CrossRefGoogle Scholar
  135. Vitetta, E. S., Poulik, M. D., Klein, J., and Uhr, J. W., 1976, J. Exp. Med. 144:179.PubMedCrossRefGoogle Scholar
  136. Walsh, F. S., and Crumpton, M. J., 1977,Nature (London) 269:307.CrossRefGoogle Scholar
  137. Waxdal, M. J., Basham, T. Y., Clement, L. T., Shevach, E. M., and Schwartz, B. D., 1979, Mol. Immunol. 16:61.PubMedCrossRefGoogle Scholar
  138. Wilson, B. S., Indiveri, F., Pellegrino, M. A., and Ferrone, S., 1979a, J. Immunol. 122:1967.PubMedGoogle Scholar
  139. Wilson, B. S., Indiveri, F., Pellegrino, M. A., and Ferrone, S., 1979b, J. Exp. Med. 149:658.PubMedCrossRefGoogle Scholar
  140. Winchester, R. J., Ross, G. D., Jarowski, C. I., Wang, C. Y., Halper, J., and Broxmeyer, H. E., 1977, Proc. Natl. Acad. Sci. U.S.A. 74:4012.PubMedCrossRefGoogle Scholar
  141. Winchester, R. J., Meyers, P. A., Broxmeyer, H. E., Wang, C. Y., Moore, M. A. S., and Kunkel, H. G., 1978a, J. Exp. Med. 148:613.PubMedCrossRefGoogle Scholar
  142. Winchester, R. J., Wang, C. Y., Gibofsky, A., Kunkel, H. G., Lloyd, K. O., and Old, L. J., 1978b, Proc. Natl. Acad. Sci. U.S.A. 75:6235.PubMedCrossRefGoogle Scholar
  143. Wofsy, L., McDevitt, H. O., and Henry, C., 1977, J. Immunol 119:61.PubMedGoogle Scholar
  144. Yamashita, U., and Shevach, E. M., 1977a, J. Immunol 119:1575.PubMedGoogle Scholar
  145. Yamashita, U., and Shevach, E. M., 1977b, J. Immunol 119:1584.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Loran T. Clement
    • 1
  • Ethan M. Shevach
    • 1
  1. 1.Laboratory of Immunology, National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA

Personalised recommendations