Idiotypic Regulation in Immune Networks

  • J. Urbain
  • C. Wuilmart
  • P.-A. Cazenave


For almost twenty years now, the clonal selection theory (Jerne, 1955; Burnet, 1959; Lederberg, 1959) has been the major paradigm for most immunologists. The clonal selection theory has a great appeal to logic and the elegance of simplicity, and it is in fact able to account for a vast body of data. The central idea of clonal selection is that the immune system is a library of precommitted clones, able to manufacture a pair of V-region polypeptides (VH and VL). It is essential to the clonal selection theory that each member of the clone expresses the same pair of V genes.


Tobacco Mosaic Virus Helper Cell Immune Network Network Concept Internal Image 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Aasted, B., and Kindt, T. J., 1976, Eur. J. Immunol 6:727.PubMedCrossRefGoogle Scholar
  2. Aasted, B., Sogn, J. A., and Kindt, T. J., 1976, J. Immunol 116:387.PubMedGoogle Scholar
  3. Adam, G., and Weiler, E., 1976, in: The Generation of Antibody Diversity: A New Look (A. J. Cunningham, ed.), Academic Press, New York.Google Scholar
  4. Aguet, M., Andersson, L. C., Wight, E., Binz, H., and Wigzell, H., 1978, J. Exp. Med. 147:50.PubMedCrossRefGoogle Scholar
  5. Antoine, J. C., Bleux, C., Avrameas, S., and Liacopoulos, P., 1919,Nature (London) 277:218.CrossRefGoogle Scholar
  6. Askonas, B. A., and Humphrey, G. H., 1958, Biochem. J. 68:252.PubMedGoogle Scholar
  7. Auerbach, R., and Clark, S., 1975, Science 189:811.PubMedCrossRefGoogle Scholar
  8. Augustin, A., and Cosenza, H., 1976, Eur. J. Immunol 6:497.PubMedCrossRefGoogle Scholar
  9. Avrameas, S., Antoine, J. C., Ternynck, T., and Petit, C., 1976, Ann. Immunol. (Paris) l27C:55l.Google Scholar
  10. Binz H., and WigzeU, H., 1977, in: Contemporary Topics in Molecular Immunology ,Volume 7 (R. A. Reisfeld and F. P. Inman, eds.), p. 113, Plenum Press, New York.CrossRefGoogle Scholar
  11. Binz, H., Frischknecht, H., and Wigzell, H., 1979, Ann. Immunol (Paris) l3OC:273.Google Scholar
  12. Boccadora, M., Van Acker. A., Pileri, A., and Urbain, J., 1981, Ann. Immunol. (Paris) (in press).Google Scholar
  13. Bona, C., and Hiernaux, J., 1980, Crit. Rev. Immunol (in press).Google Scholar
  14. Bona, C., and Paul, W. E., 1979, J. Exp. Med. 149:592.PubMedCrossRefGoogle Scholar
  15. Bona, C., Lieberman, R., Chien, C. C., Mond, J., House, S., Green, I., and Paul, W. E., 1978, J. Immunol. 120:1436.PubMedGoogle Scholar
  16. Bona C., Hooghe, R., Cazenave, P.-A., Le Guern, C., and Paul, W. E., 1979a, J. Exp. Med. 149:815.PubMedCrossRefGoogle Scholar
  17. Bona, C., Cazenave, P.-A., and Paul, W. E., 1979b, Ann. Immunol. (Paris) 130C:303.Google Scholar
  18. Bona, C., Mongini, P. K. A., and Paul, W. E., 1980, J. Exp. Med. 151:1334.PubMedCrossRefGoogle Scholar
  19. Bordenave, G., 1971, Ann. Immunol (Paris) 120:292.Google Scholar
  20. Bordenave, G. R., 1975, Immunology 28:635.PubMedGoogle Scholar
  21. Bottomly, K., and Mosier, D. E., 1980, in: Strategies of Immune Regulation (E. Sercarz and A. J. Cunningham, eds.), p. 487, Academic Press, New York.Google Scholar
  22. Braun, D. G., and Krause, R. M., 1968, J. Exp. Med. 128:969.PubMedCrossRefGoogle Scholar
  23. Brézin, C., and Cazenave, P.-A., 1915, Immunochemistry 12:241.CrossRefGoogle Scholar
  24. Brézin, C., and Cazenave, P.-A., 1976, Ann. Immunol (Paris) 127C:333.Google Scholar
  25. Brown, J. C., and Rodkey, L. S., 1978, J. Exp. Med. 150:67.CrossRefGoogle Scholar
  26. Brown, A. R. Estess, P., Lamoyi, E., Gill-Pazaris, L., Gottlieb, P. D., Capra, J. D., and Nisonoff, A., 1980, in: Membranes, Receptors and the Immune Response (E. P. Cohen and H. Kohler, eds.), p. 237, Alan R. Liss, New York.Google Scholar
  27. Bruyns, C., Urbain-Vansanten, G., Planard, C., De Vos Cloetens, C., and Urbain, J., 1976, Proc. Natl Acad. Sci. U.S.A. 73:2462.PubMedCrossRefGoogle Scholar
  28. Burnet, F. M., 1959, The Clonal Selection Theory of Acquired Immunity ,Cambridge University Press, Cambridge.Google Scholar
  29. Buttin, G., Le Guern, C., Phalente, L., Lin, E. C. C., Madrano, L., and Cazenave, P.-A., 1978, Curr. Top. Microbiol Immunobiol 81:27.Google Scholar
  30. Cantor, H., and Gershon, R. K., 1979, Fed. Proc. 38:2058.PubMedGoogle Scholar
  31. Capra, J. D., and Nisonoff, A., 1979, J. Immunol 123:279.PubMedGoogle Scholar
  32. Capra, J. D., Klapper, D. G., Tung, A. S., and Nisonoff, A., 1976, Cold Spring Harbor Symp. Quant. Biol 41:847.CrossRefGoogle Scholar
  33. Cazenave, P.-A., 1973, FEBS Lett. 31:348.PubMedCrossRefGoogle Scholar
  34. Cazenave, P.-A., 1977, Proc. Natl. Acad. Sci. U.S.A. 74:5122.PubMedCrossRefGoogle Scholar
  35. Cazenave, P.-A., and Le Guern, C., 1979, in: Cell of Immunoglobulin Synthesis (B. Pernis and H. Vogel, eds.), p. 343, Academic Press, New York.Google Scholar
  36. Cazenave, P.-A., and Oudin J. 1973, C. R. Acad. Sci. (Paris) 276:243.Google Scholar
  37. Cazenave, P.-A., Ternynck,T., and Avrameas, S., 1974, Proc. Natl Acad. Sci. U.S.A. 71:4500.PubMedCrossRefGoogle Scholar
  38. Cazenave, P.-A., Cavaillon, J. M., and Bona, C., 1977, Immunol. Rev. 321:321.Google Scholar
  39. Changeux, J. P., and Danchin, A., 1976, Nature (London) 264:705.CrossRefGoogle Scholar
  40. Conn, M., and Epstein, R., 1978, Cell Immunol 39:125.CrossRefGoogle Scholar
  41. Conn, M., Notani, G., and Rice, S. A., 1969, Immunochemistry 6:111.CrossRefGoogle Scholar
  42. Cooke, A., Hutchings, P. R., and Playfair, J. H. L., 1978, Nature (London) 273:154.CrossRefGoogle Scholar
  43. Cosenza, H., 1976, Eur. J. Immunol. 6:114.PubMedCrossRefGoogle Scholar
  44. Cosenza, H., Julius, M. H., and Augustin, A., 1977, Immunol. Rev. 34:3.PubMedCrossRefGoogle Scholar
  45. Coutinho, A., Forni, L., and Blomberg, B., 1978, J. Exp. Med. 148:862.PubMedCrossRefGoogle Scholar
  46. Cunningham, A. J., 1976, in: The Generation of Antibody Diversity: A New Look (A. J.Cunningham, ed.), p. 89, Academic Press, New York.Google Scholar
  47. Danchin, A., 1979, Mol Immunol 16:515.PubMedCrossRefGoogle Scholar
  48. Danchin, A., and Slonimski, P., 1981, Bio systems (in press).Google Scholar
  49. David, G. S., and Todd, C. W., 1969, Proc. Natl. Acad. Sci. U.S.A. 62:860.PubMedCrossRefGoogle Scholar
  50. Davis, M., Early, P., Calame, K., Livant, D., and Hood, L., 1980, in: Eukaryotic Gene Regulation R. Axel, T. Maniatis, and C. F. Fox, eds.), p. 393, INC-UCLA Symposium, Academic Press, New York.Google Scholar
  51. de Saint Martin, J., Mukoyama, H., and Eyquem, A., 1978, Ann. Immunol. (Paris) l29C:73l.Google Scholar
  52. De Vos-Cloetens, C., Minsart-Baleriaux, V., and Urbain-Vansanten, G., 1971, Immunology 20:955.PubMedGoogle Scholar
  53. Demeur, C., Wikler, M., Urbain, J., 1980, J. Exp. Med. 152:1024.PubMedCrossRefGoogle Scholar
  54. Doria, G., Agarossi, G., Boraschi, D., and Amendolea, M. A., 1977, Immunology 32: 539.PubMedGoogle Scholar
  55. Doria, G., Schiaffini, G., Garavini, H., and Mancini, C., 1972, J. Immunol. 109:1245.PubMedGoogle Scholar
  56. Doria, G., 1978, in: Immunology 1978 (J. Gergely, G. A. Medgyesi, and S. R. Hollan, eds.), Akadéìiai Kiado, Budapest.Google Scholar
  57. Dray, S., 1962, Nature (London) 195:677.CrossRefGoogle Scholar
  58. Dubiski, S., 1967, Nature (London) 214:1365.CrossRefGoogle Scholar
  59. Eichmann, K., 1974, Eur. J. Immunol. 21:296.CrossRefGoogle Scholar
  60. Eichmann, K., 1915, Immunogenetics 2:491.CrossRefGoogle Scholar
  61. Eichmann, K., 1978, Adv. Immunol 26:195.PubMedCrossRefGoogle Scholar
  62. Eichmann, K., and Rajewsky, K., 1975, Eur. J. Immunol. 5:661.PubMedCrossRefGoogle Scholar
  63. Eichmann, K., Coutinho, A., and Melchers, F., 1977, J. Exp. Med. 146:1346.CrossRefGoogle Scholar
  64. Eisen, H. N., 1966, Harvey Lect. 60:1.PubMedGoogle Scholar
  65. Eisen, H. N., and Siskind, G., 1964, Biochemistry 3:996.PubMedCrossRefGoogle Scholar
  66. Estess, P., Nisonoff, A., and Capra, J. D., 1979, Mo J. Immunol 16:1111.CrossRefGoogle Scholar
  67. Fernandez, C., and Möller, G., 1919, Proc. Natl Acad. Sci. U.S.A. 76:5944.CrossRefGoogle Scholar
  68. Fernandez, C., Hammarström, L., Möller, G., Primi, D., and Smith, C. I. E., 1979, Immunol. Rev. 43:1.CrossRefGoogle Scholar
  69. Forni, L., Cazenave, P.-A., Cosenza, H., Forsbeck, K., and Coutinho, A., 1979, Nature (London) 280:241.CrossRefGoogle Scholar
  70. Forni, L., Coutinho, A., Köhler, G., and Jerne, N. K., 1980, Proc. Natl. Acad. Sci U.S.A. 77:1125.PubMedCrossRefGoogle Scholar
  71. Firre, O., Natvig, J. B., and Michaelsen, T. E., 1977, Scand. J. Immunol 6:997.CrossRefGoogle Scholar
  72. Frischknecht, H., Binz, H., and Wigzell, H., 1978, J. Exp. Med. 147:500.PubMedCrossRefGoogle Scholar
  73. Gershon, R. K., and Paul, W. F., 1971, J. Immunol. 106:872.PubMedGoogle Scholar
  74. Goidl, E. A., Barondecs, J. J., and Siskind, G. W., 1975, Immunology 29:629.PubMedGoogle Scholar
  75. Graf, T., Kirchbach, A., Deug, H., 1979, Mod Trends Hum. Leuk. 3:429.CrossRefGoogle Scholar
  76. Haimovich, H., and Du Pasquier, L., 1976, Immunogenetics 3:381.CrossRefGoogle Scholar
  77. Hamburg, D., Briles, D. E., and Davie, J. M., 1977, J. Immunol ,119:1406.Google Scholar
  78. Hart, D. A., Wang, A. L., Pawlak, L. L., and Nisonoff, A., 1972, J. Exp. Med. 135:1293.PubMedCrossRefGoogle Scholar
  79. Harvey, M. A., Adorini, L., Benjamin, C. D., Miller, A., and Sercarz, E. D., 1979, in: T and B Lymphocytes: Recognition and Function (F. Bach, F. Bonavida, E. Vitetta, and F. Fox, eds.), p. 423, UCLA Symposium, Academic Press, New York.Google Scholar
  80. Henry, C., N. K. Jerne, 1968, J. Exp. Med. 128:133.PubMedCrossRefGoogle Scholar
  81. Herzenberg, L. A., Herzenberg, L. A., Goodling, R. C., and Rivera, E. C., 1967, J. Exp. Med. 126:701.PubMedCrossRefGoogle Scholar
  82. Hetzelberger, D., and Eichmann, K., 1978, Eur. J. Immunol. 8:846.PubMedCrossRefGoogle Scholar
  83. Hiernaux, J., 1977, Immunochemistry 14:733.PubMedCrossRefGoogle Scholar
  84. Hoffmann, G. W., 1975, Eur. J. Immunol. 5:638.PubMedCrossRefGoogle Scholar
  85. Hopper, J. E., and Nisonoff, A., 1971, Adv. Immunol. 13:58.Google Scholar
  86. Jacobson, E. B., and Herzenberg, L. A., 1972, J. Exp. Med. 135:1151.PubMedCrossRefGoogle Scholar
  87. Janeway, C. A., 1980, in: Strategies of Immune Regulation (E. Sercarz and A. J. Cunningham, eds.), p. 179, Academic Press, New York.Google Scholar
  88. Janeway, C. A., Murgita, R. A., Weinbaum, F. I., Asofsky, R., and Wigzell, H., 1977, Proc. Natl. Acad. Sci. U.S.A. 74:4582.PubMedCrossRefGoogle Scholar
  89. Jerne, N. K., 1955, Proc. Natl. Acad. Sci. U.S.A. 41:849.PubMedCrossRefGoogle Scholar
  90. Jerne, N. K., 1972, in: Ciba Foundation Symposium on Ontogeny ofAcquired Immunity,p. 1.Google Scholar
  91. Jerne, N. K., 1974, Ann. Immunol. (Paris) 125C:373.Google Scholar
  92. Jerne, N. K., 1975, in: Host Defense against Cancer and Its Potentiation ,p. 1, University Park Press, Baltimore, Md.Google Scholar
  93. Jerne, N. K., 1976a, Harvey Lect. 70:93.Google Scholar
  94. Jerne, N. K., 1976b, in: The Common Sense of Immunology ,Vol. 41, p. 4, Cold Spring Harbor, New York.Google Scholar
  95. Jerne, N. K., and Avegno, N., 1956, J. Immunol 76:200.PubMedGoogle Scholar
  96. Ju, S. T., Pierres, M., Waltenbaugh, C., Germain, R. N., Benacerraf, B., and Dorf, M. E., 1979, Proc. Natl Acad. Sci. U.S.A. 76:2942.PubMedCrossRefGoogle Scholar
  97. Ju, S. T., Gray, A., and Nisonoff, A., 1977, J. Exp. Med. 145:540.PubMedCrossRefGoogle Scholar
  98. Kaplan, D. R., and Qintans, J., 1978, J. Exp. Med. 148:987.PubMedCrossRefGoogle Scholar
  99. Karol, R. A., Reichlin, M., and Noble, R. W., 1978, J. Exp. Med. 148:1488.PubMedCrossRefGoogle Scholar
  100. Kelsoe, G., and Cerny, J., 1979, Nature (London) 279:333.CrossRefGoogle Scholar
  101. Kindred, B., and Roelants, G. B., 1974, J. Immunol 113:445.PubMedGoogle Scholar
  102. Kluskens, L., and Köhler, H., 1974, Proc. Natl. Acad. Sci. U.S.A. 71:5083.PubMedCrossRefGoogle Scholar
  103. Köhler, H., 1975, Transplant. Rev. 17:24.Google Scholar
  104. Kubagawa, H., Vogler, L., Capra, J. D., Conrad, M. E., Lawton, A. R., and Cooper, M. D., 1979, J. Exp. Med. 150:792.PubMedCrossRefGoogle Scholar
  105. Kuettner, M. G., Wang, A., and Nisonoff, A., 1972, J. Exp. Med. 135:579.PubMedCrossRefGoogle Scholar
  106. Kunkel, H. G., Mannik, M., and Williams, R. C., 1963, Science 140:1218.PubMedCrossRefGoogle Scholar
  107. Kunkel, H. G., Agnello, V., Joslin, F. G., Winchester, R. J., and Capra, J. D., 1973, J. Exp. Med. 137:331.PubMedCrossRefGoogle Scholar
  108. Lamoyi, E., Estess, P., Capra, J. D., and Nisonoff, A., 1980, J. Exp. Med. 151:863.PubMedCrossRefGoogle Scholar
  109. Lea, T., Frre, Ø. T., Michaelsen, T. E., and Natvig, J. B., 1979, J. Immunol. 122:2413.PubMedGoogle Scholar
  110. Lederberg, J., 1959, Science 129:1649.PubMedCrossRefGoogle Scholar
  111. Le Guern, C., Ben Aíssa, F., Juy, D., Mariamé, B., Buttin, G., and Cazenave, P.-A., 1979, Ann. Immunol. (Paris) 130C:293.Google Scholar
  112. Leo, O., Mariamé, B., Slaoui, M., Urbain, J., 1981, submitted manuscript.Google Scholar
  113. Lieberman, R., Paul, W. E., Humphrey, W., Jr., and Stimpfling, 1972, J. Exp. Med. 136:1231.PubMedCrossRefGoogle Scholar
  114. Lieberman, R., Potter, M., Humphrey, W., Jr., Mushinski, E. B., and Vrana, M., 1975, J. Exp. Med. 142:106.PubMedCrossRefGoogle Scholar
  115. Lieberman, R., Bona, C., Chien, C. C., Stein, K. E., and Paul, W. E., 1979, Ann. Immunol (Paris) l3OC:247.Google Scholar
  116. Lindenmann, J., 1973, Ann. Immunol (Paris) 124C:171.Google Scholar
  117. Macario, A. J. L., and Conway de Macario, E., 1973, Nature (London) 245:263.CrossRefGoogle Scholar
  118. Mage, R. G., 1979, Ann. Immunol (Paris) 130C:105.Google Scholar
  119. Mage, R., and Dray, S., 1965, J. Immunol 95:525.PubMedGoogle Scholar
  120. Mäkelä, O., and Karjalainen, K., 1977, Immunol Rev. 34:119.PubMedCrossRefGoogle Scholar
  121. Marìamé, B., Leo, O., Tasiaux, N., Urbain, J., Brézin, C., and Cazenave, P.-A., 1977, Ann. Immunol. (Paris) l28C:355.Google Scholar
  122. McCartney, N., and Mandy, W. J., 1979, Ann. Immunol (Paris) 130C:115.Google Scholar
  123. McKearn, T. J., Stuart, F. P., and Fitch, F. W., 1974, J. Immunol 113:1876.PubMedGoogle Scholar
  124. Miller, J. F. A. P., 1979, Thymus 1:3.PubMedGoogle Scholar
  125. Mitchison, N. A., 1971, Eur. J. Immunol 1:18.PubMedCrossRefGoogle Scholar
  126. Monod, J., 1970, Le Hasard et la Nécessité ,Le Seuil Editions, Paris.Google Scholar
  127. Natvig, J. B., Kunkel, H. G., Rosenfield, R. E., Dalton, J. F., and Kocheva, S., 1976, J. Immunol 116:1536.PubMedGoogle Scholar
  128. Nisonoff, A., and Bangasser, S. A., 1975, Transplant Rev. 27:100.PubMedGoogle Scholar
  129. Nossal, G. J. V., and Pike, B. L., 1980, Proc. Natl Acad. Sci. U.S.A. 77:1602.PubMedCrossRefGoogle Scholar
  130. Nussenzweig, V., Seligmann, M., Pelmount, J., and Grabar, P., 1961, Ann. Inst. Pasteur 100:377.Google Scholar
  131. Ohno, S., 1978, in: Comprehensive Immunology ,Vol. 5, Immunoglobulins (G. W. Litman and R. A. Good, eds.), p. 197, Plenum Press, New York.CrossRefGoogle Scholar
  132. Oi, V. T., and Herzenberg, L. A., 1979, Mol Immunol. 16:1005.PubMedCrossRefGoogle Scholar
  133. Okumura, D., Julius, M. H., Tsu, T., Herzenberg, L. A., and Herzenberg, L. A., 1976, Eur. J. Immunol. 6:467.PubMedCrossRefGoogle Scholar
  134. Oriol, R., and Dalix, A. M., 1977, Immunology 33:91.PubMedGoogle Scholar
  135. Oudin, J., I960, J. Exp. Med. 112:107.PubMedCrossRefGoogle Scholar
  136. Oudin, J., 1974, Antigens 2:277.Google Scholar
  137. Oudin, J., and Bordenave, G., 1971, Nature (London) 231:86.Google Scholar
  138. Oudin, J., and Cazenave, P.-A., 1971, Proc. Natl. Acad. Sci. U.S.A. 68:2616.PubMedCrossRefGoogle Scholar
  139. Oudin, J., and Michel, M., 1963, C. R. Acad. Sci. (Paris) 257:805.Google Scholar
  140. Oudin, J., and Michel, M., 1969a, J. Exp. Med. 130:595.PubMedCrossRefGoogle Scholar
  141. Oudin, J., and Michel, M., 1969b, J. Exp. Med. 130:619.PubMedCrossRefGoogle Scholar
  142. Ovary, Z., and Benacerraf, B., 1963, Proc. Soc. Exp. Biol Med. 114:72.PubMedGoogle Scholar
  143. Pini, C., Di Felice, G., Neri, R., Mancini, C., Vicari, G., and Doria, G., 1980, J. Immunol 125:1349.PubMedGoogle Scholar
  144. Potter, M., 1977, Adv. Immunol. 25:141.PubMedCrossRefGoogle Scholar
  145. Preud’homme, J. L., Klein, M., and Seligmann, M., 1977, Eur. J. Immunol. 7:840.PubMedCrossRefGoogle Scholar
  146. Rabbitts, T. H., 1977, Immunol. Rev. 36:29.PubMedCrossRefGoogle Scholar
  147. Rabbitts, T. H., and Milstein, C., 1977, in: Contemporary Topics in Molecular Immunology, Vol. 6 (R. R. Porter and G. L. Ada, eds.), p. 117, Plenum Press, New York.CrossRefGoogle Scholar
  148. Raff, M., 1970, Nature (London) ,226:1257.CrossRefGoogle Scholar
  149. Raff, M. C., Owen, J. J. T., Cooper, M. D., Lawton, A. R., Megson, M., and Gathings, W. E., 1975, J. Exp. Med. 142:1052.PubMedCrossRefGoogle Scholar
  150. Rajewsky, K., and Eichmann, K., 1977, in: Contemporary Topics in Immunobiology, Vol. 7, T Cells (O. Stutman, ed.), p. 113, Plenum Press, New York.Google Scholar
  151. Ramseier, H., and Lindenmann, J., 1972, Transplant. Rev. 10:57.PubMedGoogle Scholar
  152. Reth, M., Hämmerling, G. J., and Rajewsky, K., 1978, Eur. J. Immunol 8:393.PubMedCrossRefGoogle Scholar
  153. Richter, P. H., 1975, Eur. J. Immunol. 5:350.PubMedCrossRefGoogle Scholar
  154. Rodkey, L. S., 1974, J. Exp. Med. 139:712.PubMedCrossRefGoogle Scholar
  155. Rodkey, L. S., 1976, J. Immunol 117:986.PubMedGoogle Scholar
  156. Rodkey, L. S., 1980, in: The Handbook of Cancer Immunology ,Vol. 9 (H. Waters, ed.), Garland STPM Press (in press).Google Scholar
  157. Roland, J., and Cazenave, P.-A., 1979, C. R. Acad. Sci. (Paris) 288:571.Google Scholar
  158. Rowley, D. A., Köhler, H., and Cowan, J. D., 1980, in: Contemporary Topics in Immuno-biology ,Vol. 9, Self/ Non-Self Discrimination (J. J. Maichalonis and N. Cohen, eds.), p. 205, Plenum Press, New York.Google Scholar
  159. Sakano, H., Hüppi, K., Heinrich, G., and Tonegawa, S., 1979, Nature (London) 280:288.CrossRefGoogle Scholar
  160. Schechter, B. M., and Feldman, M., 1979, Naturwissenschaften 12:140.CrossRefGoogle Scholar
  161. Schilling J., Clevinger, B., Davie, J. M., and Hood, L., 1980, Nature (London) 283:35.CrossRefGoogle Scholar
  162. Schrater, A. F., Goidl, E. A., Thorbecke, G. J., and Siskind, G. W., 1979, J. Exp. Med. 150:138.PubMedCrossRefGoogle Scholar
  163. Schreiber, A., Couraud, O., André, C., Vray, B., and Strosberg, A. D., 1981, Proc. Natl. Acad. Sci. USA 77:7385.CrossRefGoogle Scholar
  164. Schroer, K. R., Kim, K. J., Prescott, B., and Baker, P. J., 1979, J. Exp. Med. 150:698.PubMedCrossRefGoogle Scholar
  165. Schuler, W., Weiler, E., and Kolb, H., 1977, Eur. J. Immunol. 7:649.PubMedCrossRefGoogle Scholar
  166. Sege, K., and Peterson, P. A., 1978, Nature (London) 271:167.CrossRefGoogle Scholar
  167. Seidman, J. G., and Leder, P., 1978, Nature (London) 276:790.CrossRefGoogle Scholar
  168. Seidman, J. G., Leder, A., Nau, M., Norman, B., and Leder, P., 1978, Science 202:11.PubMedCrossRefGoogle Scholar
  169. Seidman, J. G., Max, E. E., and Leder, P., 1979, Nature (London) 280:370.CrossRefGoogle Scholar
  170. Sidman, C. L., and Unanue, E. R., 1976, Nature (London) 257:149.CrossRefGoogle Scholar
  171. Siskind, G. W., and Benacerraf, B., 1969, Adv. Immunol. 10:1.PubMedCrossRefGoogle Scholar
  172. Spring-Stewart, S., and Nisonoff, A., 1973, J. Immunol. 103:629.Google Scholar
  173. Steiner, L. A., and Eisen, H. M., 1967, J. Exp. Med. 126:1143.PubMedCrossRefGoogle Scholar
  174. Stern, C. M. N., 1976, Immunology 30:443.PubMedGoogle Scholar
  175. Strosberg, A. D., 1977, Immunogenetics 4:499.CrossRefGoogle Scholar
  176. Sy, M. S., Brown, A. R., Benacerraf, B., and Greene, M. I., 1980, J. Exp. Med. 151:896.PubMedCrossRefGoogle Scholar
  177. Tada, T., Tanigushi, M., and Takemori, T., 1975, Transplant. Rev. 26:106.PubMedGoogle Scholar
  178. Tallman, J. F., Paul, S. M., Skolnick, P., and Gallager, D. W., 1980, Science 201:214.Google Scholar
  179. Tasiaux, N., Leuwenkroon, R., Bruyns, C., and Urbain, J., 1978, Eur. J. Immunol. 8:464.PubMedCrossRefGoogle Scholar
  180. Tilkin, A. F., Schaaf-Lafontaine, N., Van Acker, A., Boccadoro, M., and Urbain, J., 1981, Proc. Natl. Acad. Sci. U.S.A. 78 (in press).Google Scholar
  181. Tonegawa, S., and Steinberg, C., 1976, in: The Generation of Antibody Diversity: A New Look (A. J. Cunningham, ed.), p. 175, Academic Press, New York.Google Scholar
  182. Trenkner, F., and Riblet, R., 1975, J. Exp. Med. 142:1121.PubMedCrossRefGoogle Scholar
  183. Urbain, J., 1974, Arch. Biol 85:139.Google Scholar
  184. Urbain, J., 1976, Ann. Immunol. (Paris) 127C:1121.Google Scholar
  185. Urbain, J., 1978, in: Immunology 1978 (J. Gergely, G. A. Medgyesi, and S. R. Hollan, eds.), p. 47, Akadémiai Kiado, Budapest.Google Scholar
  186. Urbain, J., Van Acker, A., De Vos-Cloetens, C., and Urbain-Vansanten, G., 1912, Immuno-chemistry 9:121.CrossRefGoogle Scholar
  187. Urbain, J., Tasiaux, N., Leuwenkroon, R., Van Acker, A., Mariamé, B., 1975, Eur. J. Immunol. 5:570.PubMedCrossRefGoogle Scholar
  188. Urbain, J., Wikler, M., Franssen, J. D., and Collignon, C., 1977, Proc. Natl. Acad. Sci. U.S.A. 74:5126.PubMedCrossRefGoogle Scholar
  189. Urbain, J., Collignon, C., Franssen, J. D., Mariamé, B., Leo, O., Urbain-Vansanten, G., Van de Walle, P., Wikler, M., and Wuilmart, C., 1979, Ann. Immunol. (Paris) 130C:281.Google Scholar
  190. Urbain, J., Cazenave, P.-A., Wikler, M., Franssen, J. D., Mariamé, B., and Leo, O., 1980, in: Immunology 1980 (J. Dausset and M. Fougereau, eds.), p. 81, Academic Press, New York.Google Scholar
  191. Urbain-Vansanten, G., 1970, Immunology 19:783.PubMedGoogle Scholar
  192. Urbain-Vansanten, G., Van Acker, A., Mariamé, B., Tasiaux, N., De Vos-Cloetens, C., and Urbain, J., 1979, Ann. Immunol. (Paris) l3OC:397.Google Scholar
  193. Van Acker, A., Conte, F., Hulin, N., and Urbain, J., 1979a, Eur. J. Cancer 15:627.PubMedGoogle Scholar
  194. Van Acker, A., Urban-Vansanten, G., De Vos-Cloetens, C., Tasiaux, N., and Urbain, J., 1979b, Ann. Immunol. (Paris) 130C:385.Google Scholar
  195. Venkataraman, M., and Scott, D. W., 1977, J. Immunol 119:1879.PubMedGoogle Scholar
  196. Vice, J. L., Hunt, W. L., and Dray, S., 1969, J. Immunol 103:629.PubMedGoogle Scholar
  197. Voisin, G. A., 1980, Immunol Rev. 49:3.PubMedCrossRefGoogle Scholar
  198. Von Boehmer, H., Haas, W., and Jerne, N. K., 1978, Proc. Natl Acad. Sci. U.S.A. 75:2439.CrossRefGoogle Scholar
  199. Vrana, M., Rudikoff, S., and Potter, M., 1979, J. Immunol 122:1905.PubMedGoogle Scholar
  200. Weigert, M., and Riblet, R., 1978, Springer Semin. Immunopathol 1:133.CrossRefGoogle Scholar
  201. Weigert, M., Gamaitan, L., Loh, E., Shilling, J., and Hood, L., 1978, Nature (London) 276:785.CrossRefGoogle Scholar
  202. Weiler, E., and Kolb, C., 1979, Ann. Immunol (Paris) 130C:133.Google Scholar
  203. Weiler, J. J., Weiler, E., Sprenger, A., and Cosenza, H., 1977, Eur. J. Immunol. 7:591.PubMedCrossRefGoogle Scholar
  204. Wilder, M., Franssen, J. D., Collignon, C., Léo, O., Mariamé, B., Van de Walle, P., De Grotte, D., and Urbain, J., 1979, J. Exp. Med. 150:184.CrossRefGoogle Scholar
  205. Wikler, M., Demeur, C., Dewasme, G., and Urbain, J., 1980, J. Exp. Med. 152:1024.PubMedCrossRefGoogle Scholar
  206. Williams, C. R., Kunkel, H. G., and Capra, J. D., 1968, Science 161:379.CrossRefGoogle Scholar
  207. Woodland, R., and Cantor, H., 1978, Eur. J. Immunol 8:600.PubMedCrossRefGoogle Scholar
  208. Wuilmart, C., Wikler, M., and Urbain, J., 1979, Mol. Immunol 16:1085.PubMedCrossRefGoogle Scholar
  209. Yarmush, M. L., Sogn, J. A., and Kindt, T. J., 1979, Ann. Immunol (Paris) l3OC:l43.Google Scholar
  210. Zinkernagel, R. M., 1978, Immunol. Rev. 42:24.CrossRefGoogle Scholar
  211. Zinkernagel, R. M., and Doherty, P., 1977, in: Contemporary Topics in Immunobiology`9 Vol. 7, T Cells (O. Stutman, ed.), p. 119, Plenum Press, New York.Google Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • J. Urbain
    • 1
  • C. Wuilmart
    • 1
  • P.-A. Cazenave
    • 2
  1. 1.Laboratory of Animal PhysiologyFree University of BrusselsRhode-St-GenèseBelgium
  2. 2.Analytical Immunochemistry UnitPasteur InstituteParisFrance

Personalised recommendations