The Phenotypic Expression of Rabbit Immunoglobulins: A Model of Complex Regulated Gene Expression and Cellular Differentiation

  • Rose Mage


Since the discovery of rabbit allotypes (Oudin, l956a,b; Dray and Young, 1958; Dubiski et al., 1959), a considerable amount of genetic and chemical information about the immunoglobulins of the rabbit has accumulated [see, for example, reviews by Mage et al., 1973; Kindt, 1975; and Ann. Immunol. (Paris) 130C, No. 2, a special issue entitled “Jacques Oudin et les Concepts d’Allotypie des Immunoglobulines et d’Idiotypie des Anticorps,” 1979].


Light Chain Heavy Chain Constant Region Allelic Imbalance Kappa Light Chain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Appella, E., Roholt, O. A., Chersi, A., Radzimski, G., and Pressman ,D., 1973, Biochem. Biophys. Res. Commun. 53:1122.PubMedCrossRefGoogle Scholar
  2. Bast ,E. J. E. G., 1978, Ph.D. dissertation, University of Utrecht.Google Scholar
  3. Bell, C., and Wigzell, H., 1977, Eur. J. Immunol 7:726.PubMedCrossRefGoogle Scholar
  4. Bernard, O., Hozumi, N., and Tonegawa, S., 1978, Cell 15:1133.PubMedCrossRefGoogle Scholar
  5. Brack, C., Hirami, M., Lenhard-Schuller, R., and Tonegawa, S., 1978, Cell 15:1.PubMedCrossRefGoogle Scholar
  6. Braun, D. G., Huser, H., Knecht, R., and Wright, J. K., 1979, Hoppe Seylers Z. Physiol Chem 360:663.PubMedCrossRefGoogle Scholar
  7. Brezin, C., Benammar, A., Roland ,J., and Cazenave, P. A., 1979, Ann. Immunol. (Paris) l3OC:167.Google Scholar
  8. Cazenave, P.-A., Cavaillon, J. M., and Bona, C., 1977, Immunol. Rev. 34:34.PubMedCrossRefGoogle Scholar
  9. Cebra, J. J., Colberg, J. E., and Dray, S. J., 1966, J. Exp. Med. 123:547.PubMedCrossRefGoogle Scholar
  10. Chem, K. C. S., Kindt, T. J., and Krause, R. M., 1975, J. Biol Chem. 250:3289.Google Scholar
  11. Chersi, A., and Mage, R., 1980, Mol Immunol 17:135.PubMedCrossRefGoogle Scholar
  12. Chersi, A., Alexander, C., and Mage, R. 1980, Mol Immunol 17:1515.PubMedCrossRefGoogle Scholar
  13. Davie, J. M., Paul, W. E., Mage, R. G. ,and Goldman, M. B., 1971, Proc. Natl Acad. Sci U.S.A. 68:430.PubMedCrossRefGoogle Scholar
  14. Davis, M., Early, P., Calame, K., Livant, D., and Hood, L., 1979, in: Eukaryotic Gene Regulation (R. Axel, T. Maniatis, and C. F. Fox, eds.), pp. 393–406, ICN-UCLA Symposium, Academic Press, New York.CrossRefGoogle Scholar
  15. Dray S., and Young, G. O., 1958, J. Immunol 81:142.PubMedGoogle Scholar
  16. Dreyer, W. J., and Bennett, J. C., 1965, Proc. Natl Acad. Sci. USA. 54:864.PubMedCrossRefGoogle Scholar
  17. Dubiski, S., Dudziak, Z., Skalba D., and Dubiska, A., 1959, Immunology 2:84.PubMedGoogle Scholar
  18. Early, P. W., Davis, M. M., Kaback, D. B., Davidson, N., and Hood, L., 1979, Proc. Natl. Acad. Sci. U.S.A. 76:857.PubMedCrossRefGoogle Scholar
  19. Eichmann, K., 1978, Adv. Immunol. 26:195.PubMedCrossRefGoogle Scholar
  20. Eskinazi, D. P., Gilman-Sachs, A., Knight, K. L., and Dray, S., 1976, J. Immunol. 117:124.PubMedGoogle Scholar
  21. Eskinazi, D. P., Bessinger, B. A., McNicholas, J. M. ,Leary, A. N., and Knight, K. L., 1979, J. Immunol. 122:469.PubMedGoogle Scholar
  22. Farnsworth, V., Goodfleish, R. M., Rodkey, S., and Hood, L., 1976, Proc. Natl. Acad. Sei U.S.A. 73:1293.CrossRefGoogle Scholar
  23. Gainings, W. E., Mage, R., Cooper, M. D., Lawton, A. R., and Young-Cooper, G. D., 1981, Eur. J. Immunol. (in press).Google Scholar
  24. Gilman-Sachs, A., and Dray, S, 1972, Eur. J. Immunol. 2:505.PubMedCrossRefGoogle Scholar
  25. Gilman-Sachs, A., and Dray, S., 1977, J. Immunol. 118:1580.PubMedGoogle Scholar
  26. Gilman-Sachs, A., Mage, R. G., Young, G. O., Alexander, C., and Dray, S, 1969, J. Immunol. 103:1159.PubMedGoogle Scholar
  27. Gough, N. M. ,Cory, S., and Adams, J. M., 1979, Nature (London) 281:394.CrossRefGoogle Scholar
  28. Hanly, W. C. ,and Gilman-Sachs, A., 1979, in: Inbred and Gentically Defined Strains of Laboratory Animals ,Part 2 (L. R. Altman, and D. D. Katz, eds.), pp. 592–606, FASEB Biological Handbook, Bethesda, Md.Google Scholar
  29. Harrison, M. R., Mage, R. G., and Davie, J. M., 1973, J. Exp. Med. 137:254.PubMedCrossRefGoogle Scholar
  30. Hilschmann, N., and Craig, L. C., 1965,Proc. Natl Acad. Sci U.S.A. 53:1403.PubMedCrossRefGoogle Scholar
  31. Honjo, T., Obata, M., Yamawaki-Kataoka, Y., Kataoka, T., Kawakami, T., Takahashi, N., and Mano, Y., 1979, Cell 18:559.PubMedCrossRefGoogle Scholar
  32. Horng, W. J., Knight, K. L., and Dray, S., 1976, J. Immunol. 116:117.PubMedGoogle Scholar
  33. Horng, W. J., Gilman-Sachs, A., and Dray, S., 1980, in: Regulation of Function of Lympho cytes by Antibodies (C. Bona and P. A. Cazenave, eds.), pp. 139–155, Wiley, New York.Google Scholar
  34. Jaton, J.-C., Braun, D. G., Strosberg, A. D., Haber, E., and Morris, J. E., 1973, J. Immunol 111:1838.PubMedGoogle Scholar
  35. Jensenius, J. C., Williams, A. F., and Mole, L. E., 1977, Eur. J. Immunol 7:104.PubMedCrossRefGoogle Scholar
  36. Kabat, E. A., Wu, T. T., and Bilofsky, H., 1978, Proc. Natl. Acad. Sci U.S.A. 75:2429.PubMedCrossRefGoogle Scholar
  37. Kabat, E. A., Wu, T. T., and Bilofsky, H., 1979a, U.S. Public Health Service, NIH Publication No. 80–2008, Division of Research Resources, National Institutes of Health, Bethesda, Md.Google Scholar
  38. Kabat, E. A. ,Wu, T. T., and Bilofsky, H., 1979b, J. Exp. Med. 149:1299.PubMedCrossRefGoogle Scholar
  39. Kabat, E. A., Wu, T. T., and Bilofsky, H., 1980, J. Exp. Med. 152:72.PubMedCrossRefGoogle Scholar
  40. Kelus, A. S., and Weiss, S., 1977, Nature (London) 265:156.CrossRefGoogle Scholar
  41. Kemp, D. J., Cory, S., and Adams, J. M., 1979, Proc. Natl. Acad. Sci U.S.A. 76:4627.PubMedCrossRefGoogle Scholar
  42. Kindt, T. J., 1915, Adv. Immunol 21:35.CrossRefGoogle Scholar
  43. Kindt, T. J., and Todd, C. W., 1969, J. Exp. Med 130:859.PubMedCrossRefGoogle Scholar
  44. Kindt, T. J., Mandy, W. J., and Todd, C. W., 1970, Biochemistry 8:2028.CrossRefGoogle Scholar
  45. Knight, K. L., and Hanly, W. C., 1975, in: Contemporary Topics in Molecular Immunology, Vol. 4 (F. P. Inman and W. J. Mandy, eds.), pp. 55–88, Plenum Press, New York.Google Scholar
  46. Knight, K. L., Malek, T. R., and Hanly, W. C., 1974, Proc. Natl. Acad. Sci. U.S.A. 71:1169.PubMedCrossRefGoogle Scholar
  47. Knight, K. L., Schweizer, M., and Pernis, B., 1979, Eur. J. Immunol. 9:36.PubMedCrossRefGoogle Scholar
  48. Krawinkel, U., Cramer, M., Mage, R., Kelus, A. S., and Rajewsky, K., 1977, J. Exp. Med. 146:792.PubMedCrossRefGoogle Scholar
  49. Landucci-Tosi, S., Mage, R. G., and Dubiski, S., 1970, J. Immunol 104:641.Google Scholar
  50. Landucci-Tosi, S., and Tosi, R. M., 1973, Immunochemistry 10:65.CrossRefGoogle Scholar
  51. Lerner, M. R., Boyle, J. A., Mount, S. M., Wolin, S. L., and Steitz, J. A., 1980, Nature (London) 283:220.CrossRefGoogle Scholar
  52. Mage, R. G., 1975a, Transplant Rev. 26:84.Google Scholar
  53. Mage, R. G., 1975b, Fed. Proc. 34:40.PubMedGoogle Scholar
  54. Mage, R. G., 1977, in: Progress in Immunology III (Proceedings of the Third International Congress of Immunology, Sydney, Australia, 1977), pp. 289–297, Australian Academy of Science, Canberra City, Australia.Google Scholar
  55. Mage, R. G., 1979, 1979, Immunol. (Paris) 130C:105.Google Scholar
  56. Mage, R. G., Young, G. O., Rejnek, J., Reisfeld R. A., Dubiski S., and AppeUa E., 1970, in: Pro tides of the Biological Fluids (H. Peeters, ed.), p. 215, Pergamon Press, Oxford and New York.Google Scholar
  57. Mage, R., Lieberman, R., Potter, M., and Terry, W. D., 1973, in: The Antigens ,Vol. 1 (M. Sela, ed.), pp. 299–376, Academic Press, New York.Google Scholar
  58. Mandy, W. J., and Strosberg, A. D., 1978, J. Immunol. 120:1160.PubMedGoogle Scholar
  59. Max, E. E., Seidman, J. G., and Leder, P., 1979, Proc. Natl Acad. Sci. U.S.A. 76:3450.PubMedCrossRefGoogle Scholar
  60. McCartney-Francis, N., and Mandy, W. J., 1979, Ann. Immunol. (Paris) l3OC:ll5.Google Scholar
  61. Naessens, J., Hamers-Casterman C., Hamers, R., and Okerman, F., 1978, Immunogenetics 6:17.CrossRefGoogle Scholar
  62. Oudin, J., 1956a, C. R. Acad. Sci. [DJ (Paris) 242:2489.Google Scholar
  63. Oudin, J., 1956b, C. R. Acad. Sci. [D] (Paris) 242:2606.Google Scholar
  64. Pernis, B., Chiappino, M. B., Kelus, A. S., and Gell, P. G. H., 1965, J. Exp. Med. 122:853.PubMedCrossRefGoogle Scholar
  65. Pernis, B., Forni, L., Dubiski, S., Kelus, A. S., Mandy, W. J., and Todd, C. W., 1973, Immunochemistry 10:281.PubMedCrossRefGoogle Scholar
  66. Pratt, D. M., and Mole, L. E., 1975, Biochem. J. 151:337.PubMedGoogle Scholar
  67. Rejnek, J., Appella, E., Mage, R. G., and Reisfeld, R. A., 1969, Biochemistry 8:2712.PubMedCrossRefGoogle Scholar
  68. Rogers, J., and Wall, R., 1980, Proc. Natl. Acad. Sci. U.S.A. 77:1877.PubMedCrossRefGoogle Scholar
  69. Roland, J., Brezin, C., and Cazenave, P. A., 1977, Scand. J. Immunol. 6:879.PubMedCrossRefGoogle Scholar
  70. Sakano, H., Rogers, J., Huppi, K., Brack, C., Traunecker, A., Maki, R., Wall, R., and Tonegawa, S., 1979a, Nature (London) 277:627.CrossRefGoogle Scholar
  71. Sakano, H., Huppi, K., Heinrich, G., and Tonegawa, S., 1979b, Nature (London) 280:288.CrossRefGoogle Scholar
  72. Sakano, H., Maki, R., Kurosawa, Y., Roeder, W., and Tonegawa, S., 1980, Nature (London) 286:676.CrossRefGoogle Scholar
  73. Schilling, J., Clevinger, G., Davie, J. M., and Hood, L., 1980,Nature (London) 283:35.CrossRefGoogle Scholar
  74. Seidman, J. G., Leder, A., Nau, M., Normal, B., and Leder, P., 1978, Science 202:11.PubMedCrossRefGoogle Scholar
  75. Seidman, J. G., Max, E. E., and Leder, P., 1919, Nature (London) 280:370.CrossRefGoogle Scholar
  76. Seto, A., 1973, Immunochemistry 10:529.PubMedCrossRefGoogle Scholar
  77. Simons, M. A., 1979, Allotype suppression in the rabbit, Ph.D. dissertation, George Washington University.Google Scholar
  78. Simons, M. A., Hayward, A. R., Gathings, W. E., Lawton, A. R., Young-Cooper, G. O., Cooper, M. D., and Mage, R. G., 1979, Eur. J. Immunol. 9:887.PubMedCrossRefGoogle Scholar
  79. Smith, L. J., Sogn, J. A., Kindt, T. J. ,and Mandy, W. J., 1979, Eur. J. Immunol 9:27.PubMedCrossRefGoogle Scholar
  80. Sogn, J., and Kindt, T. J., 1976, J. Exp. Med. 143:1475.PubMedCrossRefGoogle Scholar
  81. Sogn, J. A., Kindt, T. J. ,1978, Immunogenetics 7:141.PubMedCrossRefGoogle Scholar
  82. Strosberg, A. D., 1977, Immunogenetics 4:449.CrossRefGoogle Scholar
  83. Strosberg, A. D., Fraser, K. J., Morgolies, M. N., and Haber, E., 1972, Biochemistry 11:4978.PubMedCrossRefGoogle Scholar
  84. Strosberg, A. D., Emorine, L., and Zeeuws, R., 1979, Ann. Immunol (Paris) 130C:157.Google Scholar
  85. Tasiaux, N., Leuwenkroon, R., Bruyns, C., and Urbain, J., 1978, Eur. J. Immunol. 8:464.PubMedCrossRefGoogle Scholar
  86. Taussig, M. J., Finch, A. P., and Kelus, A. S., 1916, Nature (London) 264:776.CrossRefGoogle Scholar
  87. Thunbeig, A. L., Lackland, H., and Kindt, T. J., 1973, J. Immunol 111:1755.Google Scholar
  88. Todd, C. W., 1963, Biochem. Biophys. Res. Commun. 11:170.PubMedCrossRefGoogle Scholar
  89. Tosi, S. L., Tosi, R. M., Mage, R., and Young-Cooper, G. O., l9lS,Immunochemistry 12:865.CrossRefGoogle Scholar
  90. Tosi, S. L., Mage, R. G., and Tosi, R. M., 1976, J. Immunol 117:679.PubMedGoogle Scholar
  91. Tucker, P. W., Marcu, K. B., Newell, N., Richards, J., and Blattner, F. R., 1979, Science 206:1303.PubMedCrossRefGoogle Scholar
  92. Van der Loo, W., Hamers-Casterman, C., and Naessens, J., 1975, Arch. Int. Physiol Biochim. 83:203.PubMedGoogle Scholar
  93. Van Hoegaerden, M., and Strosberg, A. D., 1978, Biochemistry 17:4311.PubMedCrossRefGoogle Scholar
  94. Vice, J. L., Hunt, W. L., and Dray, S., 1969, J. Immunol. 103:629.PubMedGoogle Scholar
  95. Wall, R., Choi, E., Gilmore-Hebert, M., Komaromy, M., and Rogers, J., 1980, in: Immuno globulin Genes and B Cell Differentiation (J. Battisto and K. Knight, eds.), Elsevier North-Holland, New York (in press).Google Scholar
  96. Weigert, M., Gatmaitan, L., Loh, E., Schilling, J., and Hood, L., 1978, Nature (London) 276:785.CrossRefGoogle Scholar
  97. Weigert, M., Perry R., Kelly, D. ,Hunkapiller, T., Schilling, J., and Hood, L., 1980, Nature (London) 283:497.CrossRefGoogle Scholar
  98. Wilder, R. L., Yuen, C. C., Coyle, S. A., and Mage, R. G., 1979a, J. Immunol 122:464.PubMedGoogle Scholar
  99. Wilder, R. L., Yuen, C. C., Scher, I., and Mage, R. G., 1979b, Eur. J. Immunol 9:777.PubMedCrossRefGoogle Scholar
  100. Yarmush, M. L. ,Sogn, J. A. ,Mudgett, M., and Kindt, T. J., 1977, J. Exp. Med. 145:916.PubMedCrossRefGoogle Scholar
  101. Yarmush, M. L., Sogn, J. A., and Kindt, T. J., 1979, Ann. Immunol. (Paris) 130C:143.Google Scholar
  102. Yarmush, M. L., Mandy, W. J. ,and Kindt, T. J., 1980, J. Immunol 124:2864.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Rose Mage
    • 1
  1. 1.Laboratory of ImmunologyNational Institute of Allergy and Infectious Diseases National Institutes of HealthBethesdaUSA

Personalised recommendations