Advertisement

Abstract

Myelin basic protein (MBP) has engaged the attention of molecular and cellular immunologists during the past decade because of its implication in the induction of the autoimmune disease experimental allergic encephalomyelitis (EAE) of the central nervous system (CNS). What impresses this reviewer much more, however, beyond the direct role MBP plays in the induction of an autoimmune experimental disease in certain strains of laboratory animals, is the fact that the major portion of the total MBP autoimmunology uncovered in recent years is clearly not involved in the induction of the autoimmune disease. To some the message given by this nonencephalitogenic portion possesses no greater meaning than didactic teachings from the realm of bovine serum albumin immunology; to others, this seemingly irrelevant “other” MBP immunology—an immunology against “self” that is not self-destructive—may be extremely vital. As an autoimmune process it may play a major role in the normal maintenance of protection against encephalomyelitis in most vertebrates either through direct participation or by indirect regulation. From this point of view the occasional emergence of EAE is seen as a defect in an otherwise protective immunology, a case in which horror autotoxicus is an exception to the rule.

Keywords

Myelin Basic Protein Myelin Basic Protein Peptide Human Myelin Basic Protein Major Dense Line Bovine Myelin Basic Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alvord, E. D., Jr., Hruby, S., Peterson, W. C., Barker, W. C., and Dayhoff, M. O., 1974, Fed. Proc. 33:786 (abstract).Google Scholar
  2. Barbarese, E., Braun, P. E., and Carson, J. H., 1977, Proc. Natl. Acad. Sci. U.S.A. 74:3360.PubMedCrossRefGoogle Scholar
  3. Benjamins, J. A., and McKhann, G. M., 1976, in: Basic Neurochemistry ,2nd ed. (G. L. Seigel, R. W. Albers, R. Katzman, and B. W. Agranoff, eds.), pp. 365–387, Little, Brown, Boston.Google Scholar
  4. Benjamins, J. A., and Smith, M. E., 1977, in: Myelin (P. Morell, ed.), pp. 233–270, Plenum Press, New York.Google Scholar
  5. Benuck, M., Marks, N., and Hashim, G. A., 1975, Eur. J. Biochem. 52:615.PubMedCrossRefGoogle Scholar
  6. Berg, O., and Bergstrand, H., 1974, Neurobiol. 4:191.Google Scholar
  7. Bergstrand, H., 1973, Immunochemistry 10:611.PubMedCrossRefGoogle Scholar
  8. Bergstrand, H., 1976, Acta Pathol Microbiol Scand. Sect. C 84:442.Google Scholar
  9. Bergstrand, H., and Kallen, B., 1973a, Eur. J. Immunol. 3:287.PubMedCrossRefGoogle Scholar
  10. Bergstrand, H., and Kallen, B., 1973b, Immunochemistry 10:471.PubMedCrossRefGoogle Scholar
  11. Bergstrand, H., and Kallen, B., 1975, Acta Pathol. Microbiol. Scand. Sect. C 83:165.Google Scholar
  12. Bernard, C. C. A., 1976,. J. Immunogenet. 3:263.PubMedCrossRefGoogle Scholar
  13. Bernard, C. C. A., 1977, Clin. Exp. Immunol. 29:100.PubMedGoogle Scholar
  14. Bernard, C. C. A., and Carnegie, P. R., 1975, J. Immunol 114:1537.PubMedGoogle Scholar
  15. Bernard, C. C. A., Leydon, J., and Mackay, I. R., 1976, Eur. J. Immunol 6:655.PubMedCrossRefGoogle Scholar
  16. Braun, P. E., 1977, in: Myelin (P. MorreU, ed.), pp. 91–115, Plenum Press, New York.Google Scholar
  17. Braun, P. E., and Brostoff, S. W., 1977, in: Myelin (P. MorreU, ed.), pp. 201–231, Plenum Press, New York.Google Scholar
  18. Brostoff, S. W., 1978, Birth Defects, Orig. Artic. Ser. 14:245.Google Scholar
  19. Brostoff, S. W., and Eylar, E. H., 1972, Arch. Biochem. Biophys. 153:590.PubMedCrossRefGoogle Scholar
  20. Brostoff, S. W., Powers, J. M., and Weise, M. J., 1980, Nature (London) 285:103.CrossRefGoogle Scholar
  21. Brostoff, S. W., Reuter, W., Hichens, M., and Eylar, E. H., 1974, J. Biol Chem. 249:559.PubMedGoogle Scholar
  22. Bunge, R. P., 1968,Physiol Rev. 48:197.PubMedGoogle Scholar
  23. Burgess, K. T., Bernard, C. C. A., and Carnegie, P. B., 1978, in: Myelination and Demyelination (J. Palo, ed.), pp. 303–305, Plenum Press, New York.CrossRefGoogle Scholar
  24. Carnegie, P. R., 1971, Nature (London) 229:25.CrossRefGoogle Scholar
  25. Carnegie, P. R., and Dunkley, P. R., 1975, in: Advances in Neurochemistry, Vol. 1 (B. W. Agranoff and M. H. Aprison, eds.), pp. 95–135, Plenum Press, New York.Google Scholar
  26. Carnegie, P. R. ,Dunkley, P. R., Kemp, B. E., and Murray, A. W., 1974, Nature (London) 249:147.CrossRefGoogle Scholar
  27. Chou, C.-H. J., Chou, F. C.-H., Kowalski, T. J., Shapira, R., and Kibler, R. F., 1977a, J. Neurochem. 28:115.PubMedCrossRefGoogle Scholar
  28. Chou, F. C.-H., Chou, C.-H. J., Shapira, R., and Kibler, R. F., 1977b, Neurochemistry 28: 1051.CrossRefGoogle Scholar
  29. Cohen, S. R., McKhann, G. M., and Guamieri, M., 1975, J. Neurochem. 25:371.PubMedCrossRefGoogle Scholar
  30. Day, E. D., 1972, Advanced Immunochemistry ,Williams &Williams, Baltimore, Md.Google Scholar
  31. Day, E. D., and Appel, S. H., 1970, J. Immunol. 104:710.PubMedGoogle Scholar
  32. Day, E. D., and Pitts, O. M., 1974a, Immunochemistry 11:651.PubMedCrossRefGoogle Scholar
  33. Day, E. D., and Pitts, O. M., 1974b, J. Immunol. 113:1958.PubMedGoogle Scholar
  34. Day, E. D., Roche, J. K., and Varitek, V. A., 1977, Immunochemistry 14:31.PubMedCrossRefGoogle Scholar
  35. Day, E. D., and Varitek, V. A., 1980, in: Manual of Clinical Immunology ,2nd ed. (N. R. Rose and H. Friedman, eds.), pp. 380–385, American Society of Microbiology ,Washington, D.C.Google Scholar
  36. Day, E. D., Varitek, V. A., Fujinami, R. S., and Paterson, P. Y., 1978a, Immunochemistry 15:1.PubMedCrossRefGoogle Scholar
  37. Day, E. D., Varitek, V. A., and Paterson, P. Y., 1978b, Immunochemistry 15:437.PubMedCrossRefGoogle Scholar
  38. Day, E. D., Varitek, V. A., and Paterson, P. Y., 1979, Fed. Proc. 38:1083 (abstract).Google Scholar
  39. Dayhoff, M. O., 1972, Atlas of Protein Sequence and Structure ,Vol. 5, National Biomedical Research Foundation, Washington, D.C.Google Scholar
  40. Dayhoff, M. O. and Barker, W. C., 1972, in: Atlas of Protein Sequence and Structure ,Vol. 5 (M. O. Dayhoff, ed.), pp. 41–45, National Biomedical Research Foundation, Washington, D.C.Google Scholar
  41. Deibler, G. E., Martenson, R. E., Kramer, A. J., and Kies, M. W., 1975, J. Biol Chem. 250: 7931.PubMedGoogle Scholar
  42. Dickinson, J. P., Jones, K. M., Aparicio, S. R., and Lumsden, C. E., 1970, Nature (London) 227:1133.CrossRefGoogle Scholar
  43. Driscoll, B. F., Kies, M. W., and Alvord, E. C., Jr., 1974a, J. Immunol 112:392.PubMedGoogle Scholar
  44. Driscoll, B. F., Kramer, A. J., and Kies, M. W., 1974b, Science 184:73.PubMedCrossRefGoogle Scholar
  45. Driscoll, B. F., Kies, M. W., and Alvord, E. C., Jr., 1976, J. Immunol. 117:110.PubMedGoogle Scholar
  46. Dunkley, P. R., and Carnegie, P. R., 1974, Biochem. J. 141:243.PubMedGoogle Scholar
  47. Epand, R. M., Moscarello, M. A., Ziernberg, B., and Vail, W. J., 1974, Biochemistry 13:1264.PubMedCrossRefGoogle Scholar
  48. Eylar, E. H., 1972, Ann\. N.Y. Acad. Sci. 195:481.PubMedCrossRefGoogle Scholar
  49. Eylar, E. H., Caccam, J., Jackson, J. J., Westall, F. C., and Robinson, A. B., 1970, Science 168:1220.PubMedCrossRefGoogle Scholar
  50. Eylar, E. H., Brostoff, S., Hashim, G. A., Caccam, J., and Burnett, P., 1971, J. Biol. Chem. 246:5770.PubMedGoogle Scholar
  51. Eylar, E. H., Jackson, J. J., and Kniskern, P. J., 1979, Neurochem. Res. 4:249.PubMedCrossRefGoogle Scholar
  52. Field, E. J.,Caspary, E. A., and Ball, E. J., 1963, Lancet 2:11.PubMedCrossRefGoogle Scholar
  53. Fischer, C. A., and Morell, P., 1974, Brain Res. 74:51.PubMedCrossRefGoogle Scholar
  54. Fritz, R. B., Chou, C.-H. J., Randolph, D. H., Desjardins, A. E., and Kibler, R. F., 1978, J. Immunol. 121:1865.PubMedGoogle Scholar
  55. Fritz, R. B., Desjardins, A. E., and Shapira, R., 1979, Fed. Proc. 38:1083 (abstract).Google Scholar
  56. Fujimoto, K., Roots, B. I., Burton, R. M., and Agrawal, H. C., 1976, Biochem. Biophys. Acta 426:659.PubMedCrossRefGoogle Scholar
  57. Gasser, D. L., Palm. J., and Gonatas, N. K., 1975, J. Immunol. 115:431.PubMedGoogle Scholar
  58. Golds, E. E., and Braun, P. E., 1976, J. Biol. Chem. 251:4729.PubMedGoogle Scholar
  59. Gonatas, N. K., and Howard, J. C., 1974, Science 186:839.PubMedCrossRefGoogle Scholar
  60. Gonatas, N. K., Gonatas, J. O., Stieber, A., Lisak, R., Suzuki, K., and Martenson, R. E,, 1974, Am. J. Pathol. 76:529.PubMedGoogle Scholar
  61. Hagopian, A, Westall, F. C., Whitehead, J. S., and Eylar, E. H., 1971, J. Biol. Chem. 246: 2519.PubMedGoogle Scholar
  62. Hashim, G. A., 1978, Immunol. Rev. (Transplant. Rev.) 39:60.CrossRefGoogle Scholar
  63. Hashim, G. A., and Schilling, F. J., 1973a, Arch. Biochem. Biophys. 156:287.PubMedCrossRefGoogle Scholar
  64. Hashim, G. A., and Schilling, F. J., 1973b, Biochem. Biophys. Res. Commun. 50:589.PubMedCrossRefGoogle Scholar
  65. Hashim, G. A., Sharpe, R. D., Carvalho, E. F., and Stevens, L. E., 1976, J. Immunol. 116: 126.PubMedGoogle Scholar
  66. Hashim, G. A. ,Carvalho, E. F., and Sharpe, R. D., 1978, J. Immunol. 121:665.PubMedGoogle Scholar
  67. Hashim, G. A. ,Sharpe, R. D., and Carvalho, E. F., 1979, J. Neurochem. 32:73.PubMedCrossRefGoogle Scholar
  68. Hirano, A., and Dembitzer, H. M., 1967, J. Cell. Biol. 34:555.PubMedCrossRefGoogle Scholar
  69. Hruby, S., Alvord, E. C and Shaw, C.-M., 1969, Int. Arch. Allergy ,36:599.PubMedCrossRefGoogle Scholar
  70. Kabat, E. A., Wolf, A., and Bezer, A. E., 1947, J. Exp. Med. 85:117.PubMedCrossRefGoogle Scholar
  71. Kabat, E. A., Wolf, A., and Bezer, A. E., 1948, J. Exp. Med. 88:417.PubMedCrossRefGoogle Scholar
  72. Karkhanis, Y. D., Carlo, D. J., Brostoff, S. W., and Eylar, E. H., 1975, J. Biol. Chem. 250: 1718.PubMedGoogle Scholar
  73. Karkhanis, Y. D., Zeltner, J. Y., Anderson, R. L., and Carlo, D. J., 1978, Biochemistry 17: 4577.CrossRefGoogle Scholar
  74. Keith, A. B., Arnon, R., Teitelbaum, D., Caspary, E. A. ,and Wisniewski, N. M., 1979, J. Neurol. Sci. 42:267.PubMedCrossRefGoogle Scholar
  75. Kibler, R. F., and Barnes, A. E., 1962, J. Exp. Med. 116:807.PubMedCrossRefGoogle Scholar
  76. Kies, M. W., Alvord, E. C., Jr., and Roboz, E., 1958, J. Neurochem. 2:261.PubMedCrossRefGoogle Scholar
  77. Lando, Z., Teitelbaum, D., and Arnon, R., 1979, J. Immunol. 123:2156.PubMedGoogle Scholar
  78. Lennon, V. A., and Byrd, W. J., 1913, Eur. J. Immunol. 3:243.CrossRefGoogle Scholar
  79. Lennon, V. A., and Carnegie, P. R., 1914,Eur. J. Immunol. 4:60.CrossRefGoogle Scholar
  80. Lennon, V., and Mackay, I. R., 1972, Clin. Exp. Immunol. 11:595.PubMedGoogle Scholar
  81. Lennon, V. A., Whittingham, S., Carnegie, P. R., McPherson, T. A., and Mackay, I. R., 1971, J. Immunol. 107:56.PubMedGoogle Scholar
  82. Levine, S., and Sowinski, R., 1975, J. Immunol. 114:597.PubMedGoogle Scholar
  83. Levine, S., and Wenk, E. J., 1967, J. Immunol. 99:1277.PubMedGoogle Scholar
  84. Levine, S., Wenk, E. J., Devlin, H. B., Pieroni, R. E., and Levine, L., 1966, J. Immunol. 97: 363.PubMedGoogle Scholar
  85. Lipton, M. M., and Freund, J., 1953, J. Immunol 71:380.PubMedGoogle Scholar
  86. Lisak, R. P., and Zweiman, B., 1974, Cell. Immunol. 14:252.CrossRefGoogle Scholar
  87. Lisak, R. P., Falk, G. A., Heinze, R. G., Kies, M. W., and Alvord, E. C., Jr., 1970, J. Immunol. 104:1435.PubMedGoogle Scholar
  88. Martenson, R. E., and Deibler, G. E., 1975, J. Neurochem. 24:79.PubMedCrossRefGoogle Scholar
  89. Martenson, R. E., and Gaitonde, M. K., 1969, J. Neurochem. 16:889.PubMedCrossRefGoogle Scholar
  90. Martenson, R. E., Deibler, G. E., and Kies, M. W., 1969a, J. Biol. Chem. 244:4261.PubMedGoogle Scholar
  91. Martenson, R. E., Deibler, G. E., and Kies, M. W., 1969b, J. Biol. Chew 244:4268.Google Scholar
  92. Martenson, R. E., Deibler, G. E., and Kies, M. W., 1971, J. Neurochem. 18:2427.PubMedCrossRefGoogle Scholar
  93. McFarlin, D. E., Hsu, S. C.-L., Slemenda, S. B., Chou, F. C.H., and Kibler, R. F., 1975a, J. Exp.Med. 141:72.PubMedCrossRefGoogle Scholar
  94. McFarlin, D. E., Hsu, S. C.-L., Slemenda, S. B., Chou, S. C.-H., and Kibler, R. F., 1975b, J. Immunol 115:1456.PubMedGoogle Scholar
  95. McGraw, T. P., and Swanborg, R. H., 1978, Eur. J. Immunol 8:905.PubMedCrossRefGoogle Scholar
  96. McPherson, T. A., and Carnegie, P. R., 1968, J. Lab. Clin. Med. 72:824.PubMedGoogle Scholar
  97. McPherson, T. A., Marchalonis, J. J., and Lennon, V., 1979, Immunology 19:929.Google Scholar
  98. Morgan, I. M., 1947, J. Exp. Med. 85:131.PubMedCrossRefGoogle Scholar
  99. Moscarello, M. A., 1976, in: Current Topics in Membranes and Transport ,Vol. 8 (F. Bronner and A. Kleinzeller, eds.), pp. 1–28, Academic Press, New York.Google Scholar
  100. Moscarello, M. A., Katona, E., Neumann, A. W., and Epand, R. M., 1974,Biophys. Chem. 2: 290.PubMedCrossRefGoogle Scholar
  101. Munoz, J. J., 1976, Fed. Proc. 35:813.Google Scholar
  102. Nagai, Y., Akiyama, K., Suzuki, K., Kotani, S., Watanabe, Y., Shimono, T., Shiba, T., Kusu-moto, S., Ikuta, F., and Takeda, S., 1978a, Cell. Immunol. 35:158.PubMedCrossRefGoogle Scholar
  103. Nagai, Y., Uchida, T., Takeda, S., and Ikuta, F., 1978b, Neurosci. Lett. 8:247.PubMedCrossRefGoogle Scholar
  104. Norton, W. T., 1976, in: BasicNeurochemistry ,2nd ed. (G. J. Seigel, R. W. Albers, R. Katz-man, and B. W. Agranoff, eds.), pp. 74–99, Little, Brown, Boston.Google Scholar
  105. Norton, W. T., and Poduslo, S. E., 1973, J. Neurochem. 21:759.PubMedCrossRefGoogle Scholar
  106. Orgad, S., and Cohen, I. R., 1974, Science 183:1083.PubMedCrossRefGoogle Scholar
  107. Ortiz-Ortiz, L., and Weigle, W. O., 1976, J. Exp. Med. 144:604.PubMedCrossRefGoogle Scholar
  108. Ortiz-Ortiz, L., Nakamura, R. M., and Weigle, W. O., 1976, J. Immunol. 117:576.PubMedGoogle Scholar
  109. Otterness, I., 1979, in: Varitek, V. A., and Day, E. D., 1979,Mol Immunol 16:171.Google Scholar
  110. Palfreyman, J. W., Thomas, D. G. T., and Ratcliffe, J. G., 1978, Oin. Chim. Acta 82:259.CrossRefGoogle Scholar
  111. Palo, J., ed., 1978,Myelination andDemyelination ,Plenum Press, New York.Google Scholar
  112. Paterson, P. Y., 1960, J. Exp. Med. 111:119.PubMedCrossRefGoogle Scholar
  113. Paterson,P. Y., 1966, Adv. Immunol. 5:131.PubMedCrossRefGoogle Scholar
  114. Paterson, P. Y., and Bell, J., 1962, J. Immunol 89:72.PubMedGoogle Scholar
  115. Paterson, P. Y., and Day, E. D., 1979, Hosp. Pract. 14:49.PubMedGoogle Scholar
  116. Paterson, P. Y., and Harwin, S. M., 1963, J. Exp. Med. 117:755.PubMedCrossRefGoogle Scholar
  117. Pitts, O. M., Varitek, V. A., and Day, E. D., 1975, J. Immunol. 115:1114.PubMedGoogle Scholar
  118. Pitts, O. M., Varitek, V. A., and Day, E. D., 1916, Immunochemistry 13:307.CrossRefGoogle Scholar
  119. Poduslo, J. F., and Braun, P. E., 1975, J. Biol. Chem. 250:1099.PubMedGoogle Scholar
  120. Poduslo, S. E., 1978, in: Myelination and Demyelination (J. Palo, ed.), pp. 71–94, Plenum Press, New York.CrossRefGoogle Scholar
  121. Raine, C. S., Traugott, U., and Stone, S. H., 1978a, Science 201:445.PubMedCrossRefGoogle Scholar
  122. Raine, C. S., Traugott, U., and Stone, S. H., 1978b, Acta Neuropathol. 43:43.PubMedCrossRefGoogle Scholar
  123. Randolph D. H., Kibler, R. F., and Fritz, R. B., 1977, J. Immunol Methods 18:215.PubMedCrossRefGoogle Scholar
  124. Reichlin, M., 1975, Adv. Immunol. 20:71.PubMedCrossRefGoogle Scholar
  125. Rivers, T. M., and Schwentker, F. F., 1935, J. Exp. Med. 61:689.PubMedCrossRefGoogle Scholar
  126. Roboz, E., Henderson, N., and Kies, M. W., 1958, J. Neurochem. 2:254.PubMedCrossRefGoogle Scholar
  127. Rumsby, M. G., and Crang, A. J., 1977, Cell Surf. Rev. 4:247.Google Scholar
  128. Saida, T., Saida, K., Dorfman, S. H., Silberberg, D. H., Sumner, A. J., Manning, M. C., Lisak, R., and Brown, M. J., 1979, Science 104:1103.CrossRefGoogle Scholar
  129. Schmid, G., Thomas, G., Lange, H. W., and Hempel, K., 1974, Int. Arch. Allergy Appl. Immunol 47:161.PubMedCrossRefGoogle Scholar
  130. Schonbach, J., Hu, K. H., and Friede, R. L., 1968, J. Comp. Neurol 134:21.PubMedCrossRefGoogle Scholar
  131. Shapira, R., McKneally, S. S., Chou, F., and Kibler, R. F., 1971, J. Biol Chem. 246:4630.Google Scholar
  132. Sheffield, W. D., Gonatas, N. K., and Kim, S. V., 1977, J. Immunol 119:1762.PubMedGoogle Scholar
  133. Smith, R., 1977, Biochem. Biophys. Acta 491:581.PubMedCrossRefGoogle Scholar
  134. Spitler, L. E., von Muller, C. M., Fudenberg, H. H., and Eylar, E. H., 1972, J. Exp. Med. 136:156.PubMedCrossRefGoogle Scholar
  135. Spitler, L. E., von Muller, C. M., and Young, J. D., 1975, Cell. Immunol 15:143.PubMedCrossRefGoogle Scholar
  136. Sternberger, N. H., Itoyama. Y., Kies, M. W., and Webster, H. deF., 1978a, J. Neurocytol 7:251.PubMedCrossRefGoogle Scholar
  137. Sternberger, N. H., Itoyama, Y., Kies, M. W., and Webster, H. deF., 1978b, Proc. Natl Acad. Sci. U.S.A. 75:2521.PubMedCrossRefGoogle Scholar
  138. Steward, M. W., and Petty, R. E., 1972, Immunology 22:747.PubMedGoogle Scholar
  139. Swanborg, R. H., 1975, J. Immunol 114:191.PubMedGoogle Scholar
  140. Swierkosz, J. E., and Swanborg, R. H., 1977, Immunol. Commun. 6:499.PubMedGoogle Scholar
  141. Teitelbaum, D., Webb, C., Meshorer, A., Arnon, R., and Sela, M., 1973, Eur. J. Immunol 3:273.PubMedCrossRefGoogle Scholar
  142. Teitelbaum, D., Lando, Z., and Arnon, R., 1978, in: Genetic Control of Autoimmune Diseases (N. R. Rose, P. E. Bigazzi, andN. L. Warner, eds.), P 265, Elsevier, Amsterdam.Google Scholar
  143. Trapp, B. D., Mclntyre, L. J., Quarles, R. H., Sternberger, N. H., and Webster, H. deF., 1979, Proc. Natl Acad. Sci. U.S.A. 76:3552.PubMedCrossRefGoogle Scholar
  144. Traugott, U., Stone, S. H., and Raine, C. S., 1979, J. Neurol Sci. 41:17.PubMedCrossRefGoogle Scholar
  145. Vandenbark, A. A., Burger, D. R., and Vetto, R. M., 1915,Proc. Soc. Exp. Biol. Med. 148: 1233.Google Scholar
  146. Varitek, V. A., and Day, E. D., 1979,Mol Immunol 16:163.PubMedCrossRefGoogle Scholar
  147. Varitek, V. A., Day, E. D., and Paterson, P. Y., 1980, Mol Immunol 17:127.PubMedCrossRefGoogle Scholar
  148. Wallace, A. D., Shapira, R., and Fritz, R. B., 1918, Immunochemistry 15:47.CrossRefGoogle Scholar
  149. Wardlaw, A. C., Parton, R., Bergman, R. K., and Munoz, J. J., 1979, Immunology 37:539.PubMedGoogle Scholar
  150. Webb, C., Teitelbaum, D., Arnon, R., and Sela, M., 1913, Eur. J. Immunol 3:279.CrossRefGoogle Scholar
  151. Welch, A. M., and Swanborg, R. H., 1976, Eur. J. Immunol. 6:910.CrossRefGoogle Scholar
  152. Welch, A. M., Swierkosz, J. E., and Swanborg, R. H., 1978, J. Immunol 121:1701.PubMedGoogle Scholar
  153. Westall, F. C., 1974, Immunochemistry 11:513.PubMedCrossRefGoogle Scholar
  154. Westall, F. C., and Thompson, M., 1978, Immunochemistry 15:189.PubMedCrossRefGoogle Scholar
  155. Westall, F. C., Thompson, M., and Kalter, S. S., 1975, Life Sci. 17:219.PubMedCrossRefGoogle Scholar
  156. Westall, F. C., Thompson, M., and Lennon, V. A., 1977, Nature (London) 269:425.CrossRefGoogle Scholar
  157. Westall, F. C., Lennon, V. A., and Gospodarowicz, D., 1978, Proc. Natl Acad. Sci. U.S.A. 75:4675.PubMedCrossRefGoogle Scholar
  158. Whitaker, J. N., 1978, Comp. Biochem. Physiol 59B:299.Google Scholar
  159. Whitaker, J. N., and McFarlin, D. E., 1977, Brain Res. 129:121.PubMedCrossRefGoogle Scholar
  160. Whitaker, J. N., Chou, C.-H. J., Chou, F. C.-H., and Kibler, R. F., 1975, J. Biol Chem. 250: 9106.PubMedGoogle Scholar
  161. Whitaker, J. N., Chou, C.-H. J., Chou, F. C.-H., and Kibler, R. F., 1977, J. Exp. Med. 146: 317.PubMedCrossRefGoogle Scholar
  162. Whitaker, J. N., Chou, C.-H. J., Chou, F. C.-H., and Kibler, R. F., 1979,Mol Immunol. 16: 495.PubMedCrossRefGoogle Scholar
  163. Williams, R. M., and Moore, M. J., 1973, J. Exp. Med. 138:775.PubMedCrossRefGoogle Scholar
  164. Wisniewski, H. M., and Bloom, B. R., 1975, J. Exp. Med. 141:346.PubMedCrossRefGoogle Scholar
  165. Wood, D. D., Epand, R. M., and Moscarello, M. A., 1977,Biochem. Biophys. Acta 467:120.PubMedCrossRefGoogle Scholar
  166. Wood, J. G., and King, N., 1911, Nature (London) 229:56.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Eugene D. Day
    • 1
  1. 1.Duke University Medical CenterDurhamUSA

Personalised recommendations