Effects of Acoustic Deprivation on Morphological Parameters of Development of Auditory Neurons in Rat

  • J. Coleman


Acoustical experience, along with predetermined maturation processes, appears to participate in the development of neurons of the central auditory pathway. In cat, physiological investigations have demonstrated a decrease in neural response latency with maturation (Aitkin and Moore, 1975; Romand and Marty, 1975). Sound deprivation during development was reported to produce changes in binaural interactions and latencies of neurons in the rat inferior colliculus (Silverman and Clopton, 1977; Clopton and Silverman, 1978). Morphological investigations in mice (Webster and Webster, 1977, 1979) and rats (Coleman and O’Connor, 1979) have further shown that sound attenuation during early development leads to reduction in cell size of central auditory neurons. The present investigation was aimed at morphological parameters of normal development and the effects of one form of acoustical deprivation during infancy.


Inferior Colliculus Cochlear Nucleus Endocochlear Potential Sound Attenuation Dorsal Cochlear Nucleus 
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  1. Aitkin, L. M. and Moore, D. R., 1975, Inferior colliculus. II. Development of tuning characteristics and tonotopic organization in central nucleus of the neonatal cat, J. Neurophysiol., 38: 1208–1216.PubMedGoogle Scholar
  2. Bosher, S. K. and Warren, R. L., 1971, A study of the electrochemistry and osmotic relationships of the cochlear fluids in the neonatal rat at the time of the development of the endocochlear potential, J. Physiol. (London), 212: 739–761.Google Scholar
  3. Carlier, E., Lenoir, M. and Pujol, R., 1979, Development of cochlear frequency selectivity tested by compound action potential tuning curves, Hearing Res., 1: 197–201.CrossRefGoogle Scholar
  4. Clements, M. and Kelly, J. B., 1978, Auditory spatial responses of guinea pigs (Cavia porcellus) during and after ear blocking, J. Comp. Physiol. Psychol., 92: 34–44.PubMedCrossRefGoogle Scholar
  5. Clopton, B. M. and Silverman, M. S., 1978, Changes in latency and duration of neural responding following developmental auditory deprivation, Exp. Brain Res., 32: 39–47.PubMedCrossRefGoogle Scholar
  6. Coleman, J. R. and O’Connor, P., 1979, Effects of monaural and binaural sound deprivation on cell development in the anteroventral cochlear nucleus of rats, Exp. Neurol., 64: 553–566.PubMedCrossRefGoogle Scholar
  7. Crowley, D. E. and Hepp-Reymond, M.-C., 1966, Development of cochlear function in the ear of the infant rat, J. Comp. Physiol. Psychol., 62: 427–432.CrossRefGoogle Scholar
  8. Harrison, J. M. and Irving, R., 1965, The anterior ventral cochlear nucleus, J. Comp. Neurol., 124: 15–42.PubMedCrossRefGoogle Scholar
  9. Parks, T. N., 1979, Afferent influences on the development of the brain stem auditory nuclei of the chicken: otocyst ablation, J. Comp. Neurol., 183: 665–678.PubMedCrossRefGoogle Scholar
  10. Romand, R. and Marty, R., 1975, Postnatal maturation of the cochlear nuclei in the cat: a neurophysiological study, Brain Res., 83: 225–233.PubMedCrossRefGoogle Scholar
  11. Silverman, M. S. and Clopton, B. M., 1977, Plasticity of binaural interaction. I. Effect of early auditory deprivation, J. Neurophysiol., 40: 1266–1274.PubMedGoogle Scholar
  12. Wada, T., 1923, Anatomical and physiological studies on the growth of the inner ear of the albino rat, Am. Anat. Mem. No. 10.Google Scholar
  13. Webster, D. B. and Webster, M., 1977, Neonatal sound deprivation affects brain stem auditory nuclei, Arch. Otolaryngol., 103: 392–396.PubMedCrossRefGoogle Scholar
  14. Webster, D. B. and Webster, M., 1979, Effects of neonatal conductive hearing loss on brain stem auditory nuclei, Ann. Otol. Rhinol. Laryngol., 88: 684–688.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • J. Coleman
    • 1
  1. 1.Department of PhysiologyUniversity of South CarolinaColumbiaUSA

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