Effects of Early Auditory Stimulation on Cortical Centers

  • J. Hassmannová
  • J. Mysliveček
  • V. Nováková


The aim of the present study was to investigate if and how early stimulation induces functional and biochemical changes in the cerebral cortex of the rat. We have shown previously that early complex or visual stimulation increases the protein and ribonucleic acid (RNA) content in the occipital cortex of 4-week-old rats and enhances amplitudes of visual cortical evoked potentials (EP) of adult animals (Mysliveček and Štípek, 1979). Recently (Hassmannová et al., 1980), comparing the effects of early complex (visual, auditory and somesthetic-kinesthetic) stimulation with visual stimulation alone, we were able to reveal an increase of the total RNA content in the cortical neurons of projection areas of those modalities which were involved in the early stimulation, changes in the visual projection area being most significant. A decrease in the neuronal RNA content was found in the prefrontal cortex. The present communication deals with the effects of early auditory stimulation during the second postnatal two weeks of rat ontogeny.


Prefrontal Cortex Cortical Neuron Projection Area Visual Stimulation Evoke Potential 
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  1. Hassmannová, J., Mysliveček, J. and Nováková, V., 1980, Changes of the total ribonucleic acid content in the cortical neurons after early stimulation. IBRO Monographs, Raven Press. In press.Google Scholar
  2. Mysliveček, J. and Štípek, S., 1979, Effects of early visual a and complex stimulation on learning, brain biochemistry and electrophysiology, Exp. Brain Res., 36: 343–357.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • J. Hassmannová
    • 1
  • J. Mysliveček
    • 2
  • V. Nováková
    • 3
  1. 1.Dept. of Physiology, Medical Faculty of HygieneCharles UniversityPragueCzech Republic
  2. 2.Inst. of Hygiene and EpidemiologyPragueCzechoslovakia
  3. 3.Inst. of PhysiologyCzechosl. Academy of SciencesPragueCzechoslovakia

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