Basic Biochemistry of Prostaglandin Metabolism with Especial Reference to PGDH

  • Roderick J. Flower
Part of the NATO Advanced Study Institutes Series book series


The mammalian organism possesses extremely efficient mechamisms for the catabolism of PGs and hence their biological inactivation. The effeciency of certain vascular beds — for example, the lung — in inactivating PGs is well illustrated by the observations of Ferreira and Vane (18), who found that more than 95% of infused PGE2 was inactivated during one circulation through the lungs and by those of Hamberg and Samuelsson (26), who showed that only 3% of an intravenous bolus injection of tritiated PGE2 remained in the plasma after 90 s. After 4.5 min there was no detectable PGE2 at all.


Basic Biochemistry Niflumic Acid Crude Enzyme Preparation Smooth Muscle Preparation Relative Reaction Rate 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Roderick J. Flower
    • 1
  1. 1.Department of Prostaglandin ResearchWellcome Research Laboratories Langley CourtBeckenham, KentUK

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