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Prostaglandins in Relation to Carcinomas in Man and Laboratory Animals

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The Prostaglandin System

Part of the book series: NATO Advanced Study Institutes Series ((ASIAS))

Abstract

Various studies have shown that most tumours can produce more prostaglandins (PGs) than the normal tissues in which they arise (see Ref. 1). However, we still know little about which types of PGs and related substances are formed,or about the effects of many prostanoids and lipoxygenase products on tumour growth and spread. Whereas the source of these substances is clear with pure cell lines in culture, whole tumours contain numerous different cell types which can form PGs. In the following account there are brief discussions on PGs and cell growth, endocrine tumours, breast cancer, malignant hypercalcaemia, unwanted effects of cancer therapy, and beneficial effects of PG synthesis inhibitors in mice with tumours.

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Author information

Authors and Affiliations

  1. Department of Surgery, King’s College Hospital Medical School, London, England

    Alan Bennett

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  1. Alan Bennett
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Editors and Affiliations

  1. University of Milan, Milan, Italy

    F. Berti

  2. University of Padua, Verona, Italy

    G. P. Velo

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© 1981 Plenum Press, New York

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Bennett, A. (1981). Prostaglandins in Relation to Carcinomas in Man and Laboratory Animals. In: Berti, F., Velo, G.P. (eds) The Prostaglandin System. NATO Advanced Study Institutes Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3896-3_31

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  • DOI: https://doi.org/10.1007/978-1-4684-3896-3_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3898-7

  • Online ISBN: 978-1-4684-3896-3

  • eBook Packages: Springer Book Archive

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