Abstract
The erosive activity of aspirin on the gastric mucosa is amply documented (12–15) and with regard to the mechanisms underlying this gastrotoxicity the following picture appears to emerge from the literature. By inhibiting the endogenous production of prostaglandins in the gastric wall aspirin weakens the defensive capacity of the mucosa indirectly (28). Several types of prostaglandins are reported to stimulate production of mucus (2) or to inhibit acid secretion (20) and all prostanoids tested seem to exert a cytoprotective action in the gastrointestinal tract (10,18, 21). Furthermore, back diffusion of hydrogen ions from the stomach lumen into the gastric wall through the broken mucosal barrier seems to be essential for the development of gastric damage (6,5).
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© 1981 Plenum Press, New York
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Jager, L.P., Seegers, A.J.M., van Noordwijk, J. (1981). Interactions Between Aspirin and Other Compounds in Analgesic Medicines on Gastric Mucosal Damage in Rats. In: Berti, F., Velo, G.P. (eds) The Prostaglandin System. NATO Advanced Study Institutes Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3896-3_30
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DOI: https://doi.org/10.1007/978-1-4684-3896-3_30
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