Interactions Between Aspirin and Other Compounds in Analgesic Medicines on Gastric Mucosal Damage in Rats

  • Lowie P. Jager
  • Ad J. M. Seegers
  • J. van Noordwijk
Part of the NATO Advanced Study Institutes Series book series

Abstract

The erosive activity of aspirin on the gastric mucosa is amply documented (12–15) and with regard to the mechanisms under­lying this gastrotoxicity the following picture appears to emerge from the literature. By inhibiting the endogenous production of prostaglandins in the gastric wall aspirin weakens the defensive capacity of the mucosa indirectly (28). Several types of prosta­glandins are reported to stimulate production of mucus (2) or to inhibit acid secretion (20) and all prostanoids tested seem to exert a cytoprotective action in the gastrointestinal tract (10,18, 21). Furthermore, back diffusion of hydrogen ions from the stomach lumen into the gastric wall through the broken mucosal barrier seems to be essential for the development of gastric damage (6,5).

Keywords

Toxicity Aspirin Histamine Caffeine Prostaglandin 

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Lowie P. Jager
    • 1
    • 2
  • Ad J. M. Seegers
    • 1
    • 2
  • J. van Noordwijk
    • 1
    • 2
  1. 1.Department of PharmacologyState University UtrechtThe Netherlands
  2. 2.Laboratory of PharmacologyNational Institute of Public HealthBilthovenThe Netherlands

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