Prostanoid Agonists and Antagonists: Differentiation of Prostanoid Receptors in the Gut

  • Gareth J. Sanger
  • Alan Bennett
Part of the NATO Advanced Study Institutes Series book series


Prostaglandin (PG) E and F compounds have been studied extensively on gastrointestinal muscle from several species, and various antagonists of their actions have been examined (see Ref. 1). However, less is known of the effects of the numerous other substances which can also be formed from arachidonic acid and other C20-unsaturated fatty acids.


Longitudinal Muscle Circular Muscle Mefenamic Acid Prostanoid Receptor Longitudinal Muscle Fibre 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    A. Bennett. Prostaglandin antagonists. Adv. Drug Res., 8: 83–118 (1974).PubMedGoogle Scholar
  2. 2.
    A. Bennett, C. Jaroski and D. E. Wilson. A study of receptors activated by analogues of prostaglandin H2. Br. J. Pharmac., 63: 358P (1978).Google Scholar
  3. 3.
    A. Bennett and G. J. Sanger. The effects of prostaglandin D2 on the circular muscle of guinea-pig isolated ileum and colon. Br. J. Pharmac., 63: 357P–358P (1978).Google Scholar
  4. 4.
    A. Bennett and G. J. Sanger. Trimethoquinol selectively antagonises longitudinal muscle contractions of rat isolated gastric fundus to thromboxane B2 and epoxymethano analogues of PHG2. Br. J. Pharmac., 66: 450P (1979).Google Scholar
  5. 5.
    A. Bennett and G. J. Sanger. Prostacyclin relaxes the longitudinal muscle of human isolated stomach and antagonizes contractions to some prostanoids. J. Physiol., (in press) (1979).Google Scholar
  6. 6.
    A. Bennett and G. J. Sanger, Unpublished.Google Scholar
  7. 7.
    A. Bennett, D. Pratt and G. J. Sanger. Antagonism by fenamates of prostaglandin action in guinea-pig and human alimentary muscle. Br. J. Pharmac., (in press) (1979).Google Scholar
  8. 8.
    A. Bennett, C. Jarosik, G. J. Sanger and D. E. Wilson, Unpublished.Google Scholar
  9. 9.
    S. M. Lacey and G. J. Sanger, Unpublished.Google Scholar
  10. 10.
    J. H. Sanner. Antagonism of prostaglandin E2 by 1-acetyl-2.(8-chloro-10,11-dihydrobenz (b,f) (1,4) oxazepine-l0carbonyl) hydrazine (SC-19220). Arch. Int. Pharmacodyn. Ther., 180: 45–56 (1968).Google Scholar
  11. 11.
    A. Bennett and J. Posner. Studies on prostaglandin antagonists. Br. J. Pharmac., 42: 584–594 (1971).CrossRefGoogle Scholar
  12. 12.
    J. A. Splawinski, A. S. Nies, B. Sweetman and J. A. Oates. The effects of arachidonic acid, PGE2 and PGF2α, on the longitudinal stomach strip of the rat. J. Pharmacol. Exp. Ther., 187: 501–510 (1973).PubMedGoogle Scholar
  13. 13.
    Y. Yamamura and S. Kishmoto. Clinical effectiveness of a new bronchodilator, Inolin, on bronchial asthma. Annals of Allergy, 26: 504–507 (1968).Google Scholar
  14. 14.
    D. E. Maclntyre and A. L. Willis. Trimethoquinol is a potent prostaglandin endoperoxide antagonist. Br. J. Pharmac., 63: 361P (1978).Google Scholar
  15. 15.
    O. V. Miller and W. E. Magee. Specifity of prostaglandin binding sites in rat forestomach tissue and their possible use as a quantitative assay. In: Advances in Biosciences, 9. S. Bergstrom and J. Bernhard, eds., pp.83–89. Pergamon Press (1973).Google Scholar
  16. 16.
    F. Coceani and L. S. Wolfe. On the action of prostaglandin El and prostaglanidns from brain on the isolated rat stomach. Can. J. Physiol. Pharmac., 44: 933–950 (1966).CrossRefGoogle Scholar
  17. 17.
    L. S. Wolfe, F. Coceani and C. Pace-Asciak. Brain prostaglandins and studies on the action of prostaglandins on the isolated rat stomach. In: Nobel Symp. II, Prostaglandins, Stockholm. S. Bergstom and B. Samuelsson, eds., pp. 265–276 (1967).Google Scholar
  18. 18.
    R. J. Flower. Drugs which inhibit prostaglandin biosynthesis. Pharmacol. Rev., 26: 33–67 (1974).PubMedGoogle Scholar
  19. 19.
    H. O. J. Collier and W. J. F. Sweetman. Antagonism by fenamates of prostaglandin F2α and of slow reacting substance on human bronchial muscle. Nature, 219: 864–865 (1978).CrossRefGoogle Scholar
  20. 20.
    E. L. Tolman and R. Partridge. Multiple sites of interaction between prostaglandins and non-steroidal anti-inflammatory agents. Prostaglandins, 9: 349–359 (1975).PubMedGoogle Scholar
  21. 21.
    L. Sorrentino, F. Capasso and M. Di Rosa. Indomethacin and prostaglandins. Eur. J. Pharmac., 17: 306–308 (1972).CrossRefGoogle Scholar
  22. 22.
    F. Lembeck and H. Juan. Interaction of prostaglandins and indomethacin with algesic substances. Naunyn-Schmiedeberg’s Arch. Pharmacol., 285: 301–313 (1974).PubMedCrossRefGoogle Scholar
  23. 23.
    J. P. Famaey, J. Fontaine and J. Reuse. Effect of high concentrations of non-steroidal anti-inflammatory drugs on prostaglandin-induced contraction of the guinea-pig isolated ileum. Prostaglandins, 13: 107–114 (1977).PubMedGoogle Scholar
  24. 24.
    H. Karpaanen and J. Puurunen. Antagonism of PGF2α-induced secretion of gastric acid by mefenamic acid and other fenamates. Naunyn-Schmiedeberg’s Arch. Pharmacol., 294: (Suppl) R7 (1976).Google Scholar
  25. 25.
    A. Bennett, M. A. Carroll and G. J. Sanger. Sodium flufenamate antagonises the potentiation by prostaglandins of noradrenaline-induced vasoconstriction in rat mesentary. Br. J. Pharmac., 66: 449P (1979).Google Scholar
  26. 26.
    E. W. Horton and I. H. M. Main. A comparison of the biological activities of four prostaglandins. Br. J. Pharmac. Chemother., 21: 182–189 (1963).CrossRefGoogle Scholar
  27. 27.
    E. W. Horton and I. H. M. Main. A comparison of the actions of PGF2α and PGE1 on smooth muscle. Br. J. Pharmac. Chemother., 24: 470–476 (1965).CrossRefGoogle Scholar
  28. 28.
    M. Hamberg, P. Hedqvist, K. Strandberg, J. Svensson and B. Samuelsson. Prostaglandin endoperoxides IV. Effects on smooth muscle. Life Sci., 16: 451–462 (1975).PubMedCrossRefGoogle Scholar
  29. 29.
    D. M. Engineer, U. Niederhauser, P. J. Piper and P. Sirois. Release of mediators of anaphylaxis: Inhibition of prostaglandin synthesis and the modification of release of slow reacting substance of anaphylaxis and histamine. Br. J. Pharmac., 62: 61–66 (1978).CrossRefGoogle Scholar
  30. 30.
    A. Bennett, K. G. Eley and G. B. Scholes. Effect of prostaglandins El and E2 on human, guinea-pig and rat isolated small intestine. Br. J. Pharmac., 34: 639–647 (1968).CrossRefGoogle Scholar
  31. 31.
    A. Bennett, K. G. Eley and H. L. Stockley. The effects of prostaglandins on guinea-pig isolated intestine and their possible contribution to muscle activity and tone. Br. J. Pharmac., 54: 197–204 (1975).CrossRefGoogle Scholar
  32. 32.
    B. Fleshler and A. Bennett. Responses of human, guinea-pig and rat colonic circular muscle to prostaglandins. J. Lab. Clin. Med., 74: 872 (1969).Google Scholar
  33. 33.
    A. Bennett and A. Fleshler. Prostaglandins and the gastrointestinal tract. Gastroenterology, 59: 790–800 (1970).PubMedGoogle Scholar
  34. 34.
    V. Petkov, R. Radomirov, O. Petkov and S. Todorov. The character of the antagonism by polyphloretin phosphate of contractions to prostaglandins E and F2α in guinea-pig ileum. J. Pharm. Pharmac., 30: 491–498 (1978).CrossRefGoogle Scholar
  35. 35.
    A. Bennett, C. N. Hensby, G. J. Sanger and I. F. Stamford. Identification of arachidonic acid metabolites in the human gastrointestinal tract, and the ways in which some of these affect the longitudinal muscle. In: The Prostaglandin System: Endoperoxides, Prostacyclin and Thromboxanes. F. Berti and G. P. Velo, eds., pp. 356–366. Plenum Press, New York and London (1980).Google Scholar
  36. 36.
    S. M. M. Karim. The effect of polyphloretin phosphate and other compounds on prostaglandin-induced diarrhoea in man. Annals Acad. Med., 3: 201–206 (1974).Google Scholar
  37. 37.
    K. E. Eakins. Prostaglandin antagonism by polymeric phosphates of phloretin and related compounds. Ann. N.Y. Acad. Sci., 180: 386–395 (1971).PubMedCrossRefGoogle Scholar
  38. 38.
    A. Bennett, D. Pratt and A. Schechter, Unpublished.Google Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Gareth J. Sanger
    • 1
  • Alan Bennett
    • 1
  1. 1.Department of SurgeryKing’s College Hospital Medical SchoolLondonEngland

Personalised recommendations